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SCaN: A Screening and Characterization Platform for Nanosuspensions Enables In Vivo Delivery of a Crystalline hRpn13Pru Degrader

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Proteolysis-targeting chimeras (PROTACs) and degraders have been developed against the hRpn13 fragment hRpn13Pru that is present in various cancer types. Testing the performance of these hRpn13Pru-targeting compounds in pharmacokinetic and efficacy studies has... ...