Matthew R Rice,Bharati Matta,Loretta Wang et al.
Matthew R Rice et al.
The transcription factor interferon regulatory factor 5 (IRF5) functions as an important mediator of the inflammatory response downstream of MyD88-dependent TLRs. Whereas dysregulation of IRF5 activity has been implicated in the development...
Loss of PLA2G4E compromises synaptic structure and cognitive outcomes in mice [0.03%]
PLA2G4E缺失致小鼠突触结构异常及认知缺陷
Sara Badesso,Marta Perez-Gonzalez,Sara Exposito et al.
Sara Badesso et al.
Given its potential role in supporting cognitive resilience, PLA2G4E has emerged as a compelling therapeutic target in the context of Alzheimer's disease (AD). However, its physiological functions in the central nervous system remain largel...
Accounting for differences between Infinium MethylationEPIC v2 and v1 in DNA methylation-based tools [0.03%]
英库姆甲基化EPIC微阵列v2与v1在DNA甲基化相关工具中的差异分析
Beryl C Zhuang,Marcia Smiti Jude,Chaini Konwar et al.
Beryl C Zhuang et al.
The recently launched Illumina Infinium MethylationEPIC v2.0 (EPICv2), successor of MethylationEPIC v1.0 (EPICv1), retains most of the probes in EPICv1, while expanding coverage of regulatory elements. The concordance between the two EPIC v...
Sephin1 reduces TDP-43 cytoplasmic mislocalization and improves motor neuron survival in ALS models [0.03%]
SEPHIN1可减少渐冻症模型中TDP-43的胞浆定位并改善运动神经元存活率
Emmanuelle Abgueguen,Massimo Tortarolo,Laura Rouviere et al.
Emmanuelle Abgueguen et al.
A pathological hallmark of ALS is the abnormal accumulation of misfolded proteins (e.g., TDP-43) and enlarged endoplasmic reticulum (ER), indicating ER stress. To resolve this stress, cells initiate the Unfolded Protein Response (UPR). Howe...
DEK promotes mammary hyperplasia and is associated with H3K27me3 epigenetic modifications [0.03%]
DEK促进乳腺增生并与H3K27me3表观遗传修饰相关
Megan E Johnstone,Ashley L Leck,Taylor E Lange et al.
Megan E Johnstone et al.
The DEK chromatin remodeling protein has oncogenic functions in breast cancers, but its functional role in normal mammary gland epithelium has remained unexplored. We developed two novel genetically engineered mouse models to study the role...
Hydroxyurea modulates thiol-disulfide homeostasis in the yeast endoplasmic reticulum [0.03%]
羟基脲调节酵母内质网中的硫醇-硫酯稳态
Yuki Takano,Yuki Ishiwata-Kimata,Ryo Ushioda et al.
Yuki Takano et al.
Hydroxyurea (HU) has been extensively used in laboratory settings to induce S-phase arrest and checkpoint activation. Furthermore, it has a history of clinical use as a cost-effective chemotherapeutic agent. Nevertheless, there is still unc...
GSK3A promotes human adenovirus replication and phosphorylates viral L4-22K protein [0.03%]
GSK3A促进人腺病毒复制及其对病毒L4-22K蛋白的磷酸化作用
Ying Lin,Yun Zhu,Ling Jing et al.
Ying Lin et al.
Human adenovirus B7 (HAdV-B7) is a significant respiratory pathogen in children, associated with substantial morbidity and mortality. Despite its clinical importance, the molecular mechanisms of HAdV-B7-host interaction remain poorly elucid...
Kenneth D Kuhn,Ukrae H Cho,Martin W Hetzer
Kenneth D Kuhn
The acquisition of cellular identity requires large-scale alterations in cellular state. The noncanonical proteasome activator PSME3 is known to regulate diverse cellular processes, but its importance for differentiation remains unclear. He...
Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis, and inflammation [0.03%]
大鼠白细胞介素34基因突变影响巨噬细胞的发育、稳态及炎症反应
Stephen Huang,Omkar L Patkar,Sarah Schulze et al.
Stephen Huang et al.
Interleukin 34 (IL34) and colony-stimulating factor 1 (CSF1) signal through a shared receptor (CSF1R) to control macrophage survival, differentiation, and function. Here, we describe the impact of loss-of-function mutation in the rat Il34 g...
Efficacy of Nrf2 activation in a proteinuric Alport syndrome mouse model [0.03%]
激活Nrf2治疗Alport综合征蛋白尿小鼠模型的疗效研究
Shota Kaseda,Jun Horizono,Yuya Sannomiya et al.
Shota Kaseda et al.
Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) has shown protective effects in experimental models of acute kidney injury and nonproteinuric chronic kidney disease. However, the efficacy of Nrf2 activation for proteinuric ...