Yu-Ling Miao,Li-Na Zhou,Shan-Shan Song et al.
Yu-Ling Miao et al.
The NEDD8-activating enzyme (NAE), comprising NAE1 and UBA3, is an anticancer target. The relative contribution of each of these subunits toward NAE inhibitor (NAEi) efficacy remains unclear. We demonstrated a profound interdependence of NA...
Yao Wang,Jie Wang,Yu-Ru Liu et al.
Yao Wang et al.
Accurate chromosome segregation requires efficient corrections of erroneous kinetochore-microtubule attachments during metaphase. However, the detailed mechanisms of how the erroneous attachments can be corrected in the metaphase spindle wi...
Convergent transcriptomic signature in iPSC-dopaminergic neurons of hereditary Parkinson's disease [0.03%]
Irina V Kopylova,Artem B Ivanov,Lev R Eidelman et al.
Irina V Kopylova et al.
The clinical and genetic diversity of Parkinson's disease (PD) makes it challenging to identify common mechanisms across different forms. To search for such shared pathways, we performed transcriptomic analysis of iPSC-derived dopaminergic ...
Flamenco plasticity tunes somatic piRNAs and rewires isoforms, with implications for heritable transposon spread [0.03%]
弗拉门戈适应性调节体细胞piRNA并重构异构体及其在可遗传转座子扩散中的作用
Mai Moritoh,Chikara Takeuchi,Yurika Namba et al.
Mai Moritoh et al.
Transposons drive genome innovation, yet how they evade somatic piRNA defenses, reach the germline, and rewire host genes with limited cost remain unclear. Using comparative long-read sequencing in cultured Drosophila ovarian somatic cells,...
miR-133a-3p and miR-338-3p shape neural crest derivatives in zebrafish [0.03%]
miR-133a-3p和miR-338-3p调控斑马鱼神经嵴细胞分化簇
Tomás J Steeman,Mercedes Torres,Andrea Mj Weiner et al.
Tomás J Steeman et al.
Neural crest cells are a transient, multipotent population that gives rise to diverse structures during vertebrate embryonic development, including craniofacial cartilage and pigment cells. Although the transcriptional regulation of neural ...
Metabolite import by SLC33A1 is required for ATF6 activation during endoplasmic reticulum stress [0.03%]
SLC33A1介导的代谢物输入在内质网应激期间激活ATF6中是必需的
Ginto George,Heather P Harding,Richard Kay et al.
Ginto George et al.
The transcription factor ATF6α has a central role in adapting mammalian cells to ER stress via the unfolded protein response (UPR), prompting efforts to identify ATF6α modulators. Here, an unbiased genome-wide CRISPR-Cas9 screen performed...
Locally synthesized glycyl aminoacyl-tRNA synthetase is important for local translation in neurons [0.03%]
神经元中局部合成的甘氨酰胺基-tRNA合成酶对局部翻译很重要
Tyler Brent de Leon,Adi Golani-Armon,Bar Cohen et al.
Tyler Brent de Leon et al.
Regulation of gene expression is essential for neuronal development and function. A prominent regulatory mechanism involves synthesis of proteins at their activity site. Such local protein synthesis enables neurons to respond rapidly and ti...
Corey A Osto,Eugene V Mosharov,Ayelet M Rosenberg et al.
Corey A Osto et al.
Mitochondrial respirometry, the measurement of oxygen consumption rate (OCR) by the electron transport chain (ETC), is a cornerstone of mitochondrial biology and the gold standard for measurements of mitochondrial function. However, existin...
BATF3 regulates differentiation of CD8+ T lymphocytes and memory differentiation program [0.03%]
BATF3调节CD8⁺T淋巴细胞的分化和记忆分化程序
Koji Umemura,Yasuhiro Kojima,Jakrawadee Julamanee et al.
Koji Umemura et al.
CD8+ T lymphocytes differentiate from effector to memory cells after antigen clearance, with prolonged IL-2 production characterizing functional cytotoxic T lymphocytes (CTLs). To identify transcription factors associated with sustained IL-...
Aortic carboxypeptidase-like protein potentiates β1 integrin signaling in mesenchymal progenitors [0.03%]
主动脉羧肽酶样蛋白可增强间充质前体细胞中β1整合素信号转导作用
Cheyanne L Frosti,Diana Yeritsyan,Matthew D Layne
Cheyanne L Frosti
Fibrosis is a pathological process characterized by persistent fibroblast activation and excessive ECM accumulation. Aortic carboxypeptidase-like protein (ACLP), a secreted ECM protein that binds fibrillar collagen, is up-regulated in fibro...