TEAD-independent mechanisms of YAP function in cardiomyocyte cell cycle reentry [0.03%]
YAP在心肌细胞周期重新进入中的TEAD非依赖性作用机制
Bing Xie,Jeffrey Steimle,Vaibhav Deshmukh et al.
Bing Xie et al.
Adult mammalian hearts exhibit limited regenerative capacity because of the restricted renewal of cardiomyocytes. Recent studies reveal that mammalian hearts exhibit transient regenerative potential within a short time frame after birth, su...
Notch signaling stabilizes lengths of motile cilia in multiciliated cells in the lung [0.03%]
诺特定时信号稳定肺多纤毛细胞中运动纤毛的长度
Neenu Joy,Aditya Deshpande,Sai Manoz Lingamallu et al.
Neenu Joy et al.
Airway multiciliated cells (MCs) maintain respiratory health by clearing mucus and trapped particles through coordinated ciliary beating. Although ciliary length progressively decreases along the proximal-distal (P-D) axis of the tracheobro...
Targeted recruitment of USP15 enhances CTLA4 surface levels and restricts its degradation [0.03%]
USP15的靶向招募可增强CTLA4表面水平并限制其降解
Francesca Querques,Victoria Ciampani,Pei Yee Tey et al.
Francesca Querques et al.
Induced protein proximity offers powerful new routes to modulate protein fate. Whereas proteolysis-targeting chimeras (PROTACs) promote degradation through E3 ligase recruitment, the converse principle, targeted protein stabilisation or enh...
Amyloid-β fibrils accumulated in preeclamptic placentas suppress cytotrophoblast syncytialization [0.03%]
妊娠高血压综合征胎盘中聚集的淀粉样蛋白-β原纤维可抑制细胞滋养巨噬细胞化
Kaho Nishioka,Midori Ikezaki,Naoyuki Iwahashi et al.
Kaho Nishioka et al.
Cerebral deposition of fibrillar amyloid-β (Aβ) is a pathological hallmark of Alzheimer's disease. Although Aβ is present in human placentas and accumulates in preeclamptic placentas characterized by poor placentation, the production and...
Reticulon-1 synthesis controls outgrowth and microtubule dynamics in injured cortical axons [0.03%]
视皮层轴突损伤后神经元微管动态及轴突生长受reticulon-1合成的调控
Alejandro Luarte,Javiera Gallardo,Daniela Corvalán et al.
Alejandro Luarte et al.
The regenerative potential of developing cortical axons depends on intrinsic mechanisms, such as axon-autonomous protein synthesis, that are still not fully understood. An emerging factor in this regenerative response is the bidirectional i...
Apicortin defines the Plasmodium apical conoid body but is dispensable for the parasite life cycle [0.03%]
Apicortin定义了疟原虫顶端锥体结构但对寄生虫生活周期是可有可无的蛋白质
Mohammad Zeeshan,Akancha Mishra,Sarah L Pashley et al.
Mohammad Zeeshan et al.
Apicomplexan parasites such as Plasmodium spp. and Toxoplasma gondii possess unique tubulin-based structures, including subpellicular microtubules and apical polar rings, which are essential for parasite motility, host cell invasion, and re...
Deconstruction by C. thermocellum-from microbe mediated to dynamic redistribution of cellulosomes [0.03%]
热纤梭菌的解构作用：从微生物介导到纤维素酶复合体的动态重分布
John M Yarbrough,Neal N Hengge,Qi Xu et al.
John M Yarbrough et al.
Clostridium thermocellum is one of the most efficient microorganisms for the deconstruction of cellulosic biomass. To achieve this high level of cellulolytic activity, C. thermocellum uses large multienzyme complexes known as cellulosomes t...
Selective autophagy fine-tunes Stat92E activity by degrading Su(var)2-10/PIAS in Drosophila glia [0.03%]
选择性自噬通过降解Su(var)2-10/PIAS精炼果蝇星形胶质细胞中Stat92E活性
Virág Vincze,Zsombor Esküdt,Erzsébet Fehér-Juhász et al.
Virág Vincze et al.
Glial immunity plays a pivotal role in the maintenance of nervous system homeostasis and in responses to stress conditions, including neural injuries. The transcription factor Stat92E is activated independently of the canonical JAK/STAT pat...
Brain vascular stability relies on PAK2-cilia-PDGF-BB-HSPGs on basolateral side of endothelium [0.03%]
脑血管稳定性依赖于血管内皮细胞基底侧的PAK2-纤毛-PDGF-BB-HSPGs轴
Shubhangi Prabhudesai,Karthikeyan Thirugnanam,Xuehong Song et al.
Shubhangi Prabhudesai et al.
Endothelial cells (ECs) in the brain communicate with mural cells to facilitate vascular stability. Platelet-derived growth factor-BB (PDGF-BB)/platelet-derived growth factor receptor-β (PDGFR-β) signaling mechanism at EC-mural cell inter...
Intravital imaging of the formation and resolution of MHC class II-positive T-cell activation niches [0.03%]
生命成像描绘MHC II分子阳性T细胞活化微环境的形成与消失过程
David Oleksyn,Jim Miller
David Oleksyn
Intravital imaging has revealed many of the cellular interactions that regulate immune responses, but is limited by the number of cells that can be simultaneously identified and often restricted to analysis of a single time point. We have d...