Mitochondrial dysfunction alters early endosome trafficking via microtubule reorganization [0.03%]
线粒体功能紊乱通过重组微管改变早期内体转运
Anjali Vishwakarma,Lilia Chihki,Kiran Todkar et al.
Anjali Vishwakarma et al.
Mitochondria are essential for bioenergetics and cellular processes including cell differentiation and immunity; alterations in these processes cause a wide range of muscular and neurological pathologies. Although these pathologies have tra...
Aravinth Kumar Jayabalan,Krishna Bhambhani,Anthony Kl Leung
Aravinth Kumar Jayabalan
Stress granules (SGs) are cytoplasmic biomolecular condensates enriched with RNA and translation factors. They form in response to stress, in part through phosphorylation of the translation initiation factor eIF2α, and are implicated in vi...
Human brain slice cultures: translational applications and ethical considerations [0.03%]
人脑切片培养：转化应用和伦理考量
Kevin Joseph,Ioannis Vasilikos,Juergen Grauvogel et al.
Kevin Joseph et al.
Human organotypic brain slice cultures have emerged as a pivotal tool to study the complexities of the human brain. Human organotypic brain slice cultures preserve the structural integrity, cellular diversity, and vascular networks of livin...
Beneficial and detrimental consequences of AHR activation in intestinal infection [0.03%]
肠道感染中AHR活化的利弊作用
Oscar E Diaz,Liang Zhou,Christopher Barrington et al.
Oscar E Diaz et al.
The ligand-dependent transcription factor aryl hydrocarbon receptor (AHR) is an environmental sensor whose activation can have physiologically beneficial or detrimental consequences for host immune responses depending on the ligand. Here, w...
A Drosophila screen of schizophrenia genes highlights neural and glial MMPs in neuronal remodeling [0.03%]
一个关于精神分裂症基因的果蝇筛选实验强调了神经元重塑中的神经和胶质基质金属蛋白酶
Shir Keret,Hagar Meltzer,Neta Marmor-Kollet et al.
Shir Keret et al.
Schizophrenia is a multifactorial neuropsychiatric disorder of complex and mostly unknown etiology, affected by genetic, developmental, and environmental factors. Neuroanatomical abnormalities, such as loss of gray matter, are apparent befo...
KANSL3 directs transcriptional programs essential for hepatic metabolism and differentiation [0.03%]
KANSL3调控肝脏代谢和分化的必需转录程序
Meike Wiese,Cecilia Pessoa Rodrigues,Mehmet Eray Akbas et al.
Meike Wiese et al.
Liver disease is a leading cause of mortality worldwide. Emerging evidence highlights the significant role of epigenetic regulation in sustaining liver homeostasis, providing new therapeutic strategies for liver disease. Hepatocyte-specific...
Combined ADAMTS10 and ADAMTS17 inactivation exacerbates bone shortening and skin phenotypes [0.03%]
ADAMTS10和ADAMTS17失活联合加重骨骼发育不全及皮肤表型
Nandaraj Taye,Stylianos Z Karoulias,Zerina Balic et al.
Nandaraj Taye et al.
Weill-Marchesani syndrome (WMS) is characterized by severe short stature, joint contractures, tight skin, heart valve and eye anomalies. WMS is caused by biallelic mutations in ADAMTS10, ADAMTS17, or LTBP2, or mono-allelic mutations in FBN1...
Lnk/Sh2b3 regulates initiation and severity of autoimmune insulitis and contributes to diabetes risk [0.03%]
联环素/SH2B3调节自身免疫性胰岛炎的发生及严重程度并影响糖尿病风险
Mari Tenno,Satoshi Takaki
Mari Tenno
The Lnk/Sh2b3 adaptor protein functions as a regulatory molecule for cytokine signaling in lymphohematopoiesis. A missense variant of the LNK/SH2B3 gene is reportedly a risk variant common to several autoimmune diseases, including type 1 di...
Antioxidant properties of dihydroxy B-ring flavonoids modulate circadian amplitude in Arabidopsis [0.03%]
B环二羟基黄酮的抗氧化特性调节拟南芥的昼夜节律幅度
Evan S Littleton,Sherry B Hildreth,Shihoko Kojima et al.
Evan S Littleton et al.
Flavonoids are abundant specialized metabolites produced by plants for a range of functions, including pigmentation, hormonal signaling, UV protection, and drought tolerance. We previously showed that flavonoids also influence the circadian...
Daytime SHP2 inhibitor dosing, when immune cell numbers are elevated, shrinks neurofibromas [0.03%]
日间抑制SHP2，当免疫细胞数量增加时，可缩小神经纤维瘤大小
Niousha Ahmari,Kwangmin Choi,Jianqiang Wu et al.
Niousha Ahmari et al.
Loss of NF1 in Schwann cells leads to activation of the RAS-MAPK pathway, followed by immune cell recruitment and development of benign nerve tumors (PNFs). MEK inhibitors, which shrink most PNFs, also reduce tumor-associated myeloid cells....