The APOL1 variant p.N264K is predicted to block ion flow by occluding a pore at the cell surface [0.03%]
APOL1变异p.N264K预测通过堵塞细胞表面的孔道来阻止离子流动
Verena Höffken,Lara Console,Niklas Nelde et al.
Verena Höffken et al.
The APOL1 gene variants G1 and G2 are associated with an increased risk of APOL1-mediated kidney disease. A recently identified variant, p.N264K (M1), mitigates this risk of renal damage by abolishing APOL1-G2's associated cytotoxicity. How...
The CDKL5 kinase undergoes liquid-liquid phase separation driven by a serine-rich C-terminal region [0.03%]
一种富含丝氨酸的C端区域驱动CDKL5激酶发生液-液相分离
Stefania Boggio Bozzo,Marco Dell&#x;Oca,Serena Vaglietti et al.
Stefania Boggio Bozzo et al.
The CDKL5 gene encodes a protein kinase involved in nervous system development and function. Pathogenic variants in this gene can cause a severe neurodevelopmental CDKL5 deficiency disorder (CDD). The CDKL5 protein contains a catalytic N-te...
F-actin organization excludes E-cadherin from the division furrow to ensure cytokinesis fidelity [0.03%]
F-肌动蛋白的组织排除E-钙黏着蛋白以确保分裂沟的细胞分裂保真度
Debodyuti Mondal,Megha Rai,Anup Padmanabhan
Debodyuti Mondal
Maintaining intercellular adhesion during proliferative cell division is essential for ensuring tissue integrity during embryonic development. How these two processes are coordinated in vivo remains poorly understood. During early Caenorhab...
Bridging nanomechanics and bioenergetics of single mitochondria by atomic force microscopy [0.03%]
基于原子力显微镜技术探究单个线粒体的纳米力学与生物能量学之间的关系
Ekaterina O Zorikova,Sabita Chourasia,Irit Rosenhek-Goldian et al.
Ekaterina O Zorikova et al.
Mitochondria orchestrate energy conversion and cell fate, yet label-free approaches that report both functional and physical states at the single-organelle level are nonexistent. Here, we combine atomic force microscopy (AFM) imaging with s...
Tim Fessenden
Tim Fessenden
The systemic bias against negative results allows gaps and errors to persist in the scientific record - research dead ends and flawed hypotheses left unresolved. This month Life Science Alliance showcases a collection of studies - from gene...
Metformin improves RAN protein pathology, alternative splicing, and behavioral phenotypes in SCA8 mice [0.03%]
二甲双胍改善SCA8小鼠的RAN蛋白病理、选择性剪接及行为表型
Lisa El Romano,Setsuki Tsukagoshi,Emily E Davey-Osuch et al.
Lisa El Romano et al.
Spinocerebellar ataxia type 8 (SCA8) is a member of a group of dominantly inherited, debilitating neurological diseases caused by CAG•CTG expansions for which there are no effective treatments. RAN translation, which was discovered in SCA8...
Tissue-specific I-Smad mechanisms revealed by structure-function analysis in Drosophila [0.03%]
果蝇结构功能分析揭示组织特异性I-Smad机制
Ania M Simoncek,Steven J Sviridoff,Joshua N Hays et al.
Ania M Simoncek et al.
Inhibitory Smads (I-Smads) regulate TGF-β/BMP signaling through multiple distinct mechanisms, but whether different tissues preferentially employ specific mechanisms remains unknown. To address this question, we performed structure-functio...
Rnd3 regulates lung cancer cell invasion and migration independently of ROCK1 signaling via alpha 5 integrin modulation [0.03%]
Rnd3通过α5整合素调节独立于ROCK1信号转导调节肺癌细胞侵袭和迁移
Noemi Garcia Garcia,Thanh Ha Vy Nguyen,Dane Richey et al.
Noemi Garcia Garcia et al.
Rnd3 regulates cellular processes commonly dysregulated in cancer, and altered Rnd3 expression has been linked to several cancer types. Here, we show lung adenocarcinoma patients expressing low levels of Rnd3 have significantly higher survi...
Unlocking the secrets of SARS-CoV-2 nsp3 by combining experiments with AlphaFold2 domain prediction [0.03%]
结合实验与AlphaFold2预测解开SARS-CoV-2 nsp3秘密
Maximilian Edich,Yunyun Gao,David C Briggs et al.
Maximilian Edich et al.
Nonstructural protein 3 (nsp3) is crucial for SARS-CoV-2 infection. It is the largest protein of the virus with roughly 2000 residues, and a major drug target. However, because of its size, disordered regions, and transmembrane domains, the...
Natural variations in maternal behavior shape anxiety and hippocampal neurogenesis in offspring [0.03%]
母性行为的自然变化影响后代的焦虑和海马神经发生
Fabio Grieco,Pauline van Gelderen,Maryam Ali et al.
Fabio Grieco et al.
Understanding the mechanisms of individualization of emotional traits is crucial for the development of personalized medicine in mood disorders. Although previous research focused on genetic differences or experimental manipulations of mate...