Sephin1 reduces TDP-43 cytoplasmic mislocalization and improves motor neuron survival in ALS models
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A pathological hallmark of ALS is the abnormal accumulation of misfolded proteins (e.g., TDP-43) and enlarged endoplasmic reticulum (ER), indicating ER stress. To resolve this stress, cells initiate the Unfolded Protein Response (UPR). However, unresolved stre... ...
