A Drosophila screen of schizophrenia genes highlights neural and glial MMPs in neuronal remodeling [0.03%]
一个关于精神分裂症基因的果蝇筛选实验强调了神经元重塑中的神经和胶质基质金属蛋白酶
Shir Keret,Hagar Meltzer,Neta Marmor-Kollet et al.
Shir Keret et al.
Schizophrenia is a multifactorial neuropsychiatric disorder of complex and mostly unknown etiology, affected by genetic, developmental, and environmental factors. Neuroanatomical abnormalities, such as loss of gray matter, are apparent befo...
KANSL3 directs transcriptional programs essential for hepatic metabolism and differentiation [0.03%]
KANSL3调控肝脏代谢和分化的必需转录程序
Meike Wiese,Cecilia Pessoa Rodrigues,Mehmet Eray Akbas et al.
Meike Wiese et al.
Liver disease is a leading cause of mortality worldwide. Emerging evidence highlights the significant role of epigenetic regulation in sustaining liver homeostasis, providing new therapeutic strategies for liver disease. Hepatocyte-specific...
Combined ADAMTS10 and ADAMTS17 inactivation exacerbates bone shortening and skin phenotypes [0.03%]
ADAMTS10和ADAMTS17失活联合加重骨骼发育不全及皮肤表型
Nandaraj Taye,Stylianos Z Karoulias,Zerina Balic et al.
Nandaraj Taye et al.
Weill-Marchesani syndrome (WMS) is characterized by severe short stature, joint contractures, tight skin, heart valve and eye anomalies. WMS is caused by biallelic mutations in ADAMTS10, ADAMTS17, or LTBP2, or mono-allelic mutations in FBN1...
Lnk/Sh2b3 regulates initiation and severity of autoimmune insulitis and contributes to diabetes risk [0.03%]
联环素/SH2B3调节自身免疫性胰岛炎的发生及严重程度并影响糖尿病风险
Mari Tenno,Satoshi Takaki
Mari Tenno
The Lnk/Sh2b3 adaptor protein functions as a regulatory molecule for cytokine signaling in lymphohematopoiesis. A missense variant of the LNK/SH2B3 gene is reportedly a risk variant common to several autoimmune diseases, including type 1 di...
Antioxidant properties of dihydroxy B-ring flavonoids modulate circadian amplitude in Arabidopsis [0.03%]
B环二羟基黄酮的抗氧化特性调节拟南芥的昼夜节律幅度
Evan S Littleton,Sherry B Hildreth,Shihoko Kojima et al.
Evan S Littleton et al.
Flavonoids are abundant specialized metabolites produced by plants for a range of functions, including pigmentation, hormonal signaling, UV protection, and drought tolerance. We previously showed that flavonoids also influence the circadian...
Daytime SHP2 inhibitor dosing, when immune cell numbers are elevated, shrinks neurofibromas [0.03%]
日间抑制SHP2，当免疫细胞数量增加时，可缩小神经纤维瘤大小
Niousha Ahmari,Kwangmin Choi,Jianqiang Wu et al.
Niousha Ahmari et al.
Loss of NF1 in Schwann cells leads to activation of the RAS-MAPK pathway, followed by immune cell recruitment and development of benign nerve tumors (PNFs). MEK inhibitors, which shrink most PNFs, also reduce tumor-associated myeloid cells....
Predicting nonsense-mediated mRNA decay from splicing events in sepsis using RNA-sequencing data [0.03%]
利用RNA测序数据预测脓毒症中从剪接事件诱导的靶向无意义介导的mRNA衰减
Jaewook Shin,Alger M Fredericks,Brandon E Armstead et al.
Jaewook Shin et al.
Alternative splicing (AS) and nonsense-mediated mRNA decay (NMD) are highly conserved cellular mechanisms that modulate gene expression. Here, we introduce the NMD pipeline that computes how splicing events introduce premature termination c...
Longer internal exons tend to have more tandem repeats and more frequently experience insertions and deletions [0.03%]
较长的内部外显子含有更多的串联重复序列并且更易发生插入和缺失事件
Keiichi Homma,Hiroto Anbo,Motonori Ota et al.
Keiichi Homma et al.
Insertions and deletions (indels) are known to preferentially encode intrinsically disordered regions (IDRs), regions that by themselves do not form unique three-dimensional structures. As we previously showed that long internal exons tend ...
CTPS2 regulates CTP synthetase activity by interacting with CTPS1 [0.03%]
CTPS2通过与CTPS1相互作用调节CTP合成酶活性
Norbert Minet,Benoît Heid-Picard,Vanessa Masson et al.
Norbert Minet et al.
CTP synthetases (CTPS) 1 and 2 are responsible for intracellular de novo production of the CTP nucleotide required for DNA replication and cell proliferation. CTPS1 and CTPS2 are co-expressed in most of tissues and share a high structural h...
Overexpression of ATase1 and ATase2 disrupts the secretome and causes a progeria phenotype [0.03%]
ATase1和ATase2过表达破坏分泌组并引起早衰表型
Tzu-Lin Cheng,Feixuan Wu,Md Ezazul Haque et al.
Tzu-Lin Cheng et al.
Nε-lysine acetylation in the lumen of the ER requires two acetyltransferases, ATase1/NAT8B and ATase2/NAT8. They are type II membrane proteins and belong to the larger GNAT superfamily of acetyltransferases. Their enzymatic activity is tig...