Lnk/Sh2b3 regulates initiation and severity of autoimmune insulitis and contributes to diabetes risk
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The Lnk/Sh2b3 adaptor protein functions as a regulatory molecule for cytokine signaling in lymphohematopoiesis. A missense variant of the LNK/SH2B3 gene is reportedly a risk variant common to several autoimmune diseases, including type 1 diabetes (T1D). Howeve... ...
