Deficiency of interleukin-1 receptor antagonist aggravates Citrobacter rodentium infection in mice [0.03%]
补体白介素-1受体拮抗剂缺陷通过加重鼠柠檬酸杆菌感染来诱导小鼠产生结肠炎
Beng San Yeoh,Piu Saha,Vinita Kushwaha et al.
Beng San Yeoh et al.
The interleukin-1 receptor (IL-1R) plays an important role in mediating the inflammatory responses against pathogens. However, it is not clear whether a sustained IL-1R signaling following the loss of its endogenous inhibitor, IL-1R antagon...
Exogenous arginine differentially regulates inflammatory cytokine and inducible nitric oxide synthase expression in macrophages [0.03%]
外源性精氨酸通过不同方式调节巨噬细胞的炎性细胞因子和诱导型一氧化氮合酶表达
Kelsey Stayer,Saliha Pathan,Aalekhya Biswas et al.
Kelsey Stayer et al.
Immune dysfunction and late mortality from multiorgan failure are hallmarks of severe sepsis. Arginine, a semi-essential amino acid important for protein synthesis, immune response, and circulatory regulation, is deficient in sepsis. Howeve...
Aberrant humoral immune responses and intestinal homeostasis in Cd38 Bst1 double knockout mice [0.03%]
Cd38 Bst1 双敲除小鼠中异常的体液免疫反应及肠内稳态失调
Ayano Yahagi,Masanori Iseki,Keisuke Yaku et al.
Ayano Yahagi et al.
Bone marrow stromal cell antigen-1 (BST-1)/CD157 and CD38 are ectoenzymes belonging to the mammalian ADP-ribosyl cyclase family. Previous analyses of BST-1-deficient mice (Bst1KO) in a 129×C57BL/6J(B6) mixed background revealed that BST-1 ...
Interleukin-27-producing cells in gram-negative neonatal sepsis display diverse phenotypes and functions in the liver [0.03%]
产生IL-27的细胞在革兰氏阴性新生儿败血症中表现出肝脏中的多样表型和功能
Jordan K Vance,Nathalie Lailler,Ashley M Divens et al.
Jordan K Vance et al.
Neonates have increased vulnerability to life-threatening infections due to the distinct immune landscape. Interleukin (IL)-27 is a key component of this immune profile that we have previously shown to be elevated in both newborn humans and...
Influenza A virus disruption of dendritic cell-natural killer cell crosstalk impacts activation of naïve helper and cytotoxic T cell subsets [0.03%]
甲型流感病毒通过干扰树突细胞-自然杀伤细胞相互作用影响 naive 帮助性和细胞毒性T细胞亚群的活化
Connor A Morson,Chandana K Uppalapati,Brina S Lopez et al.
Connor A Morson et al.
Dendritic cells (DCs) and natural killer (NK) cells engage in reciprocal interactions to trigger an efficient innate immune response while governing downstream adaptive immunity. Here, we used an ex vivo autologous human primary immune cell...
Characterization of extensive diversity in immunoglobulin light chain variable germline genes across biomedically important mouse strains [0.03%]
重要医学小鼠品系中免疫球蛋白轻链可变基因组广泛的多样性特征分析
Justin T Kos,Yana Safonova,Kaitlyn Shields et al.
Justin T Kos et al.
The light chain immunoglobulin (IG) genes of inbred mouse strains are poorly documented in current gene databases. We previously showed that IG heavy chain (IGH) loci of wild-derived mouse strains, representing the major mouse subspecies, c...
Maturation of thymocytes with a monoclonal TCR under control of Trac promoter elements in the absence of β-selection [0.03%]
在缺乏β选择的情况下，胸腺细胞在Tcrα单克隆受体控制下成熟发育的研究
Alexander K Tsai,Eduardo Cruz-Hinojoza,Madeline A Ellefson et al.
Alexander K Tsai et al.
Thymocyte maturation is a tightly controlled and sequential process of T cell receptor (TCR) gene rearrangement that generates a broad repertoire of T cells with minimal self-reactivity. We previously generated TCR exchange (TRex) mice by t...
ICAM-1 autoantibodies detected in healthy individuals and cross-react with functional epitopes [0.03%]
健康个体中检测到ICAM-1自身抗体并与功能表位交叉反应
Marc L Herman,Eric S Geanes,Rebecca McLennan et al.
Marc L Herman et al.
Intracellular adhesion molecule 1 (ICAM-1) is a cell surface glycoprotein that regulates cell-cell interactions, signaling, and immune processes. ICAM-1 expression has been shown to be elevated in many types of infections and inflammatory d...
Giardia increases macrophage production of the anti-inflammatory cytokine interleukin-10 in response to lipopolysaccharide via macrophage galactose binding lectin [0.03%]
溶组织内阿米巴感染调控巨噬细胞模式识别受体诱导的炎症反应研究进展
Vanessa V Angelova,Rita T Kosile,Matthew Darmadi et al.
Vanessa V Angelova et al.
Giardia duodenalis is an intestinal protozoan parasite common in low- and middle-income countries. Infection is often subclinical, even when it is associated with other pathologies like growth stunting in children. Recent longitudinal cohor...
Imprints of somatic hypermutation on B-cell receptor immunoglobulins post-infection versus post-vaccination against SARS-CoV-2 [0.03%]
感染新冠病毒与接种疫苗后体细胞高突变对B细胞受体免疫球蛋白的印迹效应之比较
Elisavet Vlachonikola,Nikolaos Pechlivanis,Georgios Karakatsoulis et al.
Elisavet Vlachonikola et al.
Published evidence supports significant heterogeneity of immune responses among individuals infected with or vaccinated against SARS-CoV-2. This highlights the need for in-depth investigation of the implicated processes toward refined under...