Milk-derived osteopontin influences the composition of the intestinal intraepithelial lymphocyte compartment [0.03%]
牛奶来源的骨桥素影响肠上皮内淋巴细胞组成
Kathleen G McClanahan,Jayden Capella,Jennifer A Gaddy et al.
Kathleen G McClanahan et al.
Osteopontin is a protein with many physiological roles widely expressed by many cell types, tissues, and bodily fluids, including breastmilk. The functions of breastmilk osteopontin are not clearly defined, however, it is known to impact in...
B cells inhibit IL-1 family cytokine production and Mycobacterium tuberculosis growth in human CD14+ cells [0.03%]
B细胞通过抑制人类CD14⁺细胞中IL-1家族细胞因子的产生而抑制结核杆菌的生长
Abhinav Vankayalapati,Bharath Somasundram,Padmaja Paidipally et al.
Abhinav Vankayalapati et al.
The IL-1 family of cytokines produced by antigen-presenting cells plays important roles in various diseases and infections, including Mycobacterium tuberculosis (Mtb) infection. In the present study, we infected human monocyte-derived macro...
Loss of Dmrta1 alters CD8+ T cell activation and resistance to influenza virus infection [0.03%]
Dmrta1缺失可改变CD8+t细胞活化及对流感病毒感染的易感性
Hiroyuki Kondo,Kunihiro Otsuka,Junko Morimoto et al.
Hiroyuki Kondo et al.
The generation and function of effector and memory CD8+ T cells are crucial for effective immune responses and long-term immunity. Using gene expression analysis, we found that doublesex- and mab-3-related transcription factor like family A...
Type I interferon production in myeloid cells is regulated by factors independent of Ptpn22 [0.03%]
髓系细胞中I型干扰素的产生由Ptpn22之外的因素调节
Jenna R Barnes,Anam Fatima Shaikh,Alec M Bevis et al.
Jenna R Barnes et al.
The immune regulatory gene PTPN22 is expressed in all immune cells and encodes lymphoid protein (Lyp) in humans and the ortholog PEST domain-enriched phosphatase (PEP) in mice. The PTPN22 alternative allele, 1858C>T, is expressed in 5% to 1...
Perioperative poly(I:C) reverses accelerated tumor growth after surgery in neuroblastoma [0.03%]
手术前后应用poly(I:C)可逆转神经母细胞瘤的加速生长现象
Chenkai Mao,Maria Poimenidou,Donna McAllister et al.
Chenkai Mao et al.
Surgery for local control is a cornerstone of anticancer therapy with demonstrated survival benefit. However, surgery-induced modulation of antitumor immunity may also contribute to cancer progression and relapse. Despite evidence for a pro...
Shared and distinct responses of human and murine alveolar macrophages and monocyte-derived macrophages to Mycobacterium tuberculosis [0.03%]
人和小鼠肺巨噬细胞和单核细胞来源的巨噬细胞对结核分枝杆菌的共同与不同的反应
Kimberly A Dill-McFarland,Glenna Peterson,Pamelia N Lim et al.
Kimberly A Dill-McFarland et al.
Macrophages are important sites of bacterial replication and host immune responses during Mycobacterium tuberculosis (Mtb) infection with distinct roles for alveolar macrophages (AMs) early in infection and monocyte-derived macrophages (MDM...
A viral vector prime and protein boost vaccine regimen elicits higher binding antibody titers than a homologous viral vector prime-boost regimen [0.03%]
病毒载体初次接种和蛋白质加强免疫的疫苗方案比同种病毒载体初次及加强免疫方案产生更高的抗体水平
Bakare Awakoaiye,Tanushree Dangi,Pablo Penaloza-MacMaster
Bakare Awakoaiye
(SARS-CoV-2) has infected a large fraction of the human population. Currently, most individuals have developed immunity either through vaccination or natural infection. Despite this, SARS-CoV-2 booster immunizations are still recommended to...
Tumor cells upregulate CCL22 in a STING-dependent manner in response to paracrine factors released by STING-activated myeloid cells and type I interferons [0.03%]
肿瘤细胞通过STING依赖性上调CCL22以响应由活化于MyD88途径的髓系细胞释放旁分泌因子和I型干扰素的作用
Elmira M Lomashvili,Jihyun Kim,Lingwei Kong et al.
Elmira M Lomashvili et al.
Immunosuppressive elements within the tumor microenvironment include both regulatory T cells (Tregs) and M2 macrophages. A well-described mechanism of Treg recruitment occurs via the chemokine CCL22, and CCL22 has also recently been implica...
Detection of pre-existing immunity to bacterial Cas9 proteins in people with cystic fibrosis [0.03%]
囊性纤维化患者对细菌Cas9蛋白既往感染的检测
Gregory Serpa,Qiaoke Gong,Mithu De et al.
Gregory Serpa et al.
Cystic fibrosis (CF) is caused by homozygous mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting in multi-organ dysfunction and decreased lifespan and quality of life. A durable cure for CF will likel...
LIGHT in combination with IL-13 or IL-17 drives inflammatory transcriptional signatures in human pulmonary fibroblasts relevant for human lung disease [0.03%]
LIGHT与IL-13或IL-17结合可驱动人肺成纤维细胞的炎症转录特征，从而引发人类肺部疾病
Nandita Ghosh,Rinkesh Kumar Gupta,Jeamin Jung et al.
Nandita Ghosh et al.
Fibroblasts are structural cells primarily involved in tissue remodeling, but recent single-cell RNA sequencing (RNA-seq) transcriptomic data have highlighted their potential to display molecules linked to inflammation. The factors that dri...