Type I interferon production in myeloid cells is regulated by factors independent of Ptpn22
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The immune regulatory gene PTPN22 is expressed in all immune cells and encodes lymphoid protein (Lyp) in humans and the ortholog PEST domain-enriched phosphatase (PEP) in mice. The PTPN22 alternative allele, 1858C>T, is expressed in 5% to 15% of the North Amer... ...
