Neurogranin negatively regulates gene expression and proinflammatory mediator release in allergen-activated mast cells [0.03%]
神经粒素可负向调控过敏原活化肥大细胞中的基因表达和促炎介质释放
Katie D Hunter,Robert W E Crozier,Ryan W Baranowski et al.
Katie D Hunter et al.
Mast cells are critical players in the maladaptive immune responses underlying biphasic reactions in allergic inflammation. Neurogranin (Ng) is an IQ domain-containing protein that sequesters Calmodulin under low [Ca2+] and negatively regul...
The influence of exercise modality on the inflammatory response to high-intensity interval training [0.03%]
运动方式对高强度间歇训练炎性反应的影响
Juliet Moore,Jonathan Katz,George Salem
Juliet Moore
The effect of exercise on immune system activation and regulation has been well studied in athletes following long-duration exercise and elite events, and across various modalities; however, little work has been performed using shorter-dura...
Randomized Controlled Trial
ImmunoHorizons. 2026 May 13;10(5):vlag022. DOI:10.1093/immhor/vlag022 2026
RANKL inhibits macrophage proinflammatory Toll-like receptor 2 and 4 signaling and impairs killing of intracellular bacteria [0.03%]
核因子κB受体活化剂配基能够抑制巨噬细胞的促炎性TLR2/4信号转导并减弱对胞内细菌的杀伤作用
Clara D Si,Christopher T Peek,Sana R Fatah et al.
Clara D Si et al.
Monocyte-macrophage lineage cells, crucial components of the innate immune system, can uniquely form bone-resorbing osteoclasts upon exposure to the cytokine receptor activator of nuclear factor κB ligand (RANKL) in the bone microenvironme...
Nasal humoral immunity: the first line of protection against respiratory pathogens [0.03%]
鼻黏膜免疫：抵御呼吸道病原体的第一道防线
Lena Hansen,Jenna J Guthmiller
Lena Hansen
The nasal cavity is the first site of infection for respiratory pathogens, and control of pathogens at this site is critical for limiting disease progression. Mucosal immunity in the respiratory tract has historically been studied in the lu...
Hanna N Degefu,Sierra A Kleist,Pamela C Rosato
Hanna N Degefu
Tissue-resident memory T cells (TRM) are a distinct subset of memory T cells that persist long-term within non-lymphoid tissues and provide rapid, localized immune protection. The central nervous system (CNS) was among the first sites in wh...
Clonal amplification of peripheral CD4+ and CD8+ T cells is associated with clinical response to checkpoint blockade in chronic hepatitis B [0.03%]
慢性乙型肝炎患者外周CD4+和CD8+T细胞克隆扩增与免疫检查点抑制治疗应答相关性研究
Samuel C Kim,Christopher Richards,Mario Cortese et al.
Samuel C Kim et al.
Therapeutic strategies for chronic hepatitis B (CHB) aim to achieve functional cure, specifically defined by sustained off-treatment elimination of hepatitis B virus (HBV) surface antigen. New treatment approaches are being developed to enh...
Development of a flow cytometry method to measure antidrug antibodies against CAR T cells [0.03%]
开发用于测量针对CAR-T细胞的抗药抗体的流式细胞术方法
Georgia Day,Francisco Javier Sánchez-Martín,Lisa Seavers et al.
Georgia Day et al.
Chimeric antigen receptor (CAR) T cell therapies are based on the genetic modification of the T cell receptor of a patient's own T cells. The resulting CAR T cells cytotoxic response is redirected against a specific tumor antigen. This inno...
Cellular and molecular interactions underlying the peripheral immune responses to blood-stage malaria infections [0.03%]
疟原虫血症感染诱发外周免疫反应的细胞和分子机制研究
Kieran Tebben,Rosita Asawa,David Serre et al.
Kieran Tebben et al.
Malaria, caused by Plasmodium species, is one of the most widespread illnesses globally, affecting millions of individuals each year. The complex life cycle of these parasites requires a multifaceted approach from the human immune system to...
Miguel Reina-Campos
Miguel Reina-Campos
Tissue immunity must meet the architectural and physiological demands of each organ, from viral entry in the respiratory tract to immune surveillance in the gastrointestinal mucosa. Recent advances in spatial technologies and computational ...