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Neurogranin negatively regulates gene expression and proinflammatory mediator release in allergen-activated mast cells

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Mast cells are critical players in the maladaptive immune responses underlying biphasic reactions in allergic inflammation. Neurogranin (Ng) is an IQ domain-containing protein that sequesters Calmodulin under low [Ca2+] and negatively regulates calmodulin-medi... ...