Fetal Pathogenesis of Scoliosis Suggested by Asymmetry of Gene Expression in Paravertebral Muscles [0.03%]
脊柱侧凸发病机制的胎儿病理学研究：胸腰段椎旁肌基因表达不对称性分析
Tian Cheng,Gamze Yazgeldi Gunaydin,Elisabet Einarsdottir et al.
Tian Cheng et al.
Background: The dysfunction of paravertebral muscles may contribute to the development of idiopathic scoliosis. Several candidate genes have been linked to scoliosis, but the underlying mechanisms and cell types remain un...
Christine Strauss,Daniel Djojic,Johannes Stadlmann et al.
Christine Strauss et al.
Background: Intervertebral disc (IVD) degeneration is associated with severe clinical symptoms including chronic back pain. Galectins are a family of carbohydrate-binding proteins, some of which can induce functional dise...
Surviving the Nucleus Pulposus Desert: Next-Generation Strategies for Intervertebral Disc Cell Therapy [0.03%]
椎间盘细胞治疗的下一代策略：穿越髓核沙漠 Surviving the Nucleus Pulposus Desert
Tynhinane Hamidouche,Namdev More,Tiffany Lee et al.
Tynhinane Hamidouche et al.
Background: Low back pain remains the leading cause of disability worldwide, with intervertebral disc degeneration representing a major biological contributor. Although cell-based therapies have shown promise in preclinic...
Spatial Investigation of Facet Joint Cartilage Properties Reveals Specific Structure-Function Relationships [0.03%]
关节面软骨属性的空间研究揭示了特定的结构功能关系
Luisa de Roy,Ann-Kathrin Greiner-Perth,Graciosa Quelhas Teixeira et al.
Luisa de Roy et al.
Background: Facet joints are highly susceptible to osteoarthritis, which can manifest in distinct patterns of cartilage degeneration across the facet joint surfaces. Understanding how cartilage structure translates into f...
Transgenic Conversion of Omega-6 to Omega-3 Fatty Acids via fat-1 Reduces Obesity-Related Intervertebral Disc Degeneration [0.03%]
通过fat-1转化欧米茄-6和欧米茄-3脂肪酸减少肥胖相关椎间盘退变
Shirley N Tang,Kristin L Lenz,Emma Shen et al.
Shirley N Tang et al.
Introduction: Low back pain is a leading cause of disability, largely due to intervertebral disc (IVD) degeneration. Obesity is a risk factor for IVD degeneration and promotes the release of pro-inflammatory cytokines fro...
Semi-Automated μCT-Based Modeling of Vertebral Bony Endplate Microporosity and Mechanical Properties: Linking Microstructure to Inferred Mechanical Performance [0.03%]
基于μCT的半自动椎体终板骨微孔隙和力学性能建模：从微观结构到推断机械性能的关系
Ahmad Alminnawi,Gabriele Nasello,Katherine B Crump et al.
Ahmad Alminnawi et al.
Background: The vertebral bony endplate (BEP) plays a role in regulating both mechanical load transfer and nutrient transport to the intervertebral disc, functions strongly influenced by its microstructural porosity. Vari...
Correction to "Feasibility of Physical Exam and Performance-Based Tests in Individuals With Chronic Low Back Pain: A Descriptive Study" [0.03%]
对“慢性下腰痛患者体格检查和基于绩效测试的可行性：描述性研究”的纠正
[This corrects the article DOI: 10.1002/jsp2.70096.]. © 2026 The Author(s). JOR Spine published by Wiley Periodicals LLC on behalf of Orthopaedic Resear...
Published Erratum
JOR spine. 2026 Jul 21;9(3):e70205. DOI:10.1002/jsp2.70205 2026
A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain Via Notochordal Cell Loss and Pain-Inducing Nucleus Pulposus Cell Emergence [0.03%]
猪椎间盘损伤模型通过软骨细胞丢失和产生疼痛的椎间盘细胞出现再现人类椎间盘源性疼痛
Giselle Kaneda,Jacob T Wechsler,Melissa Chavez et al.
Giselle Kaneda et al.
Background: Lower back pain (LBP) is one of the most common causes of disability, with up to 40% of LBP cases attributed to intervertebral disc (IVD) degeneration. While small animal models are widely used to study IVD de...
Large Language Models in Preclinical Spine Research: A Scoping Review and Expert Perspective on Evidence-Aware Experimental Workflows [0.03%]
大型语言模型在脊柱基础研究中的应用：基于证据的实验工作流程综述及专家视角
Siegmund Lang,Stefan Motov,Jonas Krueckel et al.
Siegmund Lang et al.
Background: Preclinical spine research is limited by heterogeneous experimental reporting, fragmented documentation, and barriers to reproducibility and translational alignment. Large language models (LLMs) and related ar...
Lost in Translation: Why Biologic Therapies for Intervertebral Disc Degeneration and Low Back Pain Have Not Reached the Clinic (Yet): Bridging Biology, Pain Phenotyping, and Trial Design [0.03%]
从生物学到临床：椎间盘退变和下背痛生物治疗的转化困境及解决策略
Luca Ambrosio,Jordy Schol,Clara Ruiz-Fernandez et al.
Luca Ambrosio et al.
From preclinical promise to clinical translation in intervertebral disc degeneration (IDD). Robust preclinical evidence supports a range of biologic therapies, with consistent improvements in imaging, extracellular matrix composition, infla...