Influence of the Intervertebral Disc Microenvironment on Matrix Synthesis and Metabolism in Goat Nucleus Pulposus Cells [0.03%]
微环境对山羊椎间盘髓核细胞基质合成和代谢的影响
Niamh Wilson,Tara Ní Néill,Jake McDonnell et al.
Niamh Wilson et al.
Background: The intervertebral disc (IVD) microenvironment plays a crucial role in cellular function and viability. Although the precise cause of IVD degeneration remains unclear, it is associated with progressive disrupt...
Sex Hormones Attenuate Pro-Inflammatory Gene Expression in Nucleus Pulposus and Annulus Fibrosus Cells in a Cell-Type Specific Manner [0.03%]
性激素以细胞类型特异性方式降低髓核和纤维环细胞中促炎基因表达
Jeffrey L Hutchinson,Andrew E Leung,Cheryle A Séguin
Jeffrey L Hutchinson
Background: Intervertebral disc (IVD) degeneration is a major contributor to back pain and disability. The cause of IVD degeneration is multifactorial, with no disease-modifying treatments. Sex steroids, primarily testost...
Metastatic Spine Disease Alters Vertebral Load-To-Strength Ratios in Cancer Patients Compared to Healthy Individuals [0.03%]
与健康人相比，癌症患者的转移性脊柱疾病改变了椎体的载荷-强度比
Dennis E Anderson,Mario Keko,Joanna James et al.
Dennis E Anderson et al.
Purpose: This study investigated the effect of bone metastasis on the biomechanical environment of human vertebrae in patients with metastatic spine disease through the metric of load-to-strength ratio (LSR). Specifically...
A Multiscale Ex Vivo Method to Investigate Intervertebral Disc Strain and Fiber Recruitment in Anterolateral Bending Using 9.4T MRI-DVC and DIC Microscopy [0.03%]
一种多尺度体外方法，用于使用9.4T MRI-DVC和DIC显微镜研究前外侧弯曲下的椎间盘应变和纤维募集
T D Slater,K A Raftery,V M van Heeswijk et al.
T D Slater et al.
Study design: Ex vivo, multiscale analysis of disc strain using ultrahigh-field MRI-based digital volume correlation (MRI-DVC) and differential interference contrast (DIC) microscopy. ...
Regenerative Potential of Extracellular Vesicles on Intervertebral Disc Degeneration: What is the EV-idence? [0.03%]
外泌体在椎间盘再生中的潜力：证据何在？
Daniele Corraini,Chantal Voskamp,Marca H M Wauben et al.
Daniele Corraini et al.
Background: Extracellular vesicles (EVs) represent a promising cell-free regenerative therapy. Deciphering their mode and mechanism of action comes with technical and biological challenges. This scoping review presents a ...
Introduction to a Special Issue Describing an Observational Cohort of Adults With Chronic Low Back Pain [0.03%]
一篇关于慢性下腰痛成人观察队列的专题介绍
Nam V Vo,Gwendolyn A Sowa
Nam V Vo
Editorial
JOR spine. 2025 Dec 25;8(4):e70150. DOI:10.1002/jsp2.70150 2025
Understanding the Physiological Behavior of Disc Cells in an In Vitro Imitation of the Healthy and Degenerated Disc Niche [0.03%]
理解健康和退变椎间盘生态位模拟中髓核细胞的生理行为
Joseph Snuggs,Shaghayegh Basatvat,Exarchos Kanelis et al.
Joseph Snuggs et al.
Introduction: The natural environment within the nucleus pulposus (NP) is hypoxic, acidic, low in nutrition, and exerts a high osmotic pressure. NP cells have adapted to this harsh environment; however, in vitro condition...
Enhanced Quantitative Assessment of Lumbar Facet Joint Degeneration: Refining the Joint Degeneration Grading System With Grayscale Curve Fitting and Imaging Parameter [0.03%]
改良腰椎小关节退变定量评估：基于灰度曲线拟合及影像参数的小关节分级系统修订
Xiaowen Liu,Mingjian Sun,Shouyu He et al.
Xiaowen Liu et al.
Background: Low back pain (LBP) is a leading cause of disability, often progressing to chronic low back pain (CLBP), which often involves facet joint degeneration. The Weishaupt grading system is widely used to evaluate f...
Macrophage Subtypes Distinctly Impact Intervertebral Disc Inflammation and Extracellular Matrix Composition [0.03%]
巨噬细胞亚型对椎间盘炎症和细胞外基质组成的影响不同
Lauren E Lisiewski,Leonardo Campos,Timothy D Jacobsen et al.
Lauren E Lisiewski et al.
Background: Intervertebral disc (IVD) degeneration is characterized by changes in extracellular matrix (ECM) composition and an inflammatory microenvironment, including macrophage recruitment. While inflammation is known ...
Comparative Finite Element Analysis of Denosumab and Bazedoxifene on Pedicle Screw Stability in Osteoporotic Spines [0.03%]
比较分析择那单抗和贝唑来昔芬对骨质疏松症脊柱椎弓根螺钉稳定性的有限元分析
Tomoyuki Asada,Soji Tani,Tomoko Towatari et al.
Tomoyuki Asada et al.
Introduction: Pedicle screw fixation in osteoporotic spines remains challenging. Bazedoxifene (BZA) and denosumab (Dmab) are widely used agents for osteoporosis, but their comparative effects on spinal instrumentation are...