Effectiveness of Lung Cancer Screening by Sex and Tumor Histology: Extended, Pooled Analysis of the ITALUNG and LUSI Trials, with Comparison to Findings in the NLST [0.03%]
Rudolf Kaaks,Francisco Omar Cortés-Ibáñez,Stefan Delorme et al.
Rudolf Kaaks et al.
CEBPB Expression in Tumor Cells Drives Immune Evasion in Colorectal Cancer via CTLA4 Up-regulation in T Cells [0.03%]
Hye Jeong Yun,Chan Ho Park,Dahye Yun et al.
Hye Jeong Yun et al.
Background: Immune checkpoint inhibitors are ineffective in the majority of colorectal cancers (CRCs) that are microsatellite stable. However, the underlying reasons for their unresponsiveness and mechanisms of immune evasion are poorly und...
WTAP-Mediated Glutaminase Splicing Bias Suppresses Ferroptosis in Hepatocellular Carcinoma [0.03%]
WTAP介导的谷氨酰胺酶拼接偏倚可抑制肝细胞癌中的铁死亡
Can Zhu,Ke Wu,Tong Wu et al.
Can Zhu et al.
Background: Hepatocellular carcinoma (HCC), a highly aggressive malignancy with poor prognosis, is characterized by hyperactivation of the epidermal growth factor receptor (EGFR) signaling pathway. Glutaminase (GLS) is commonly overexpresse...
Multiplexed CRISPR/Cas9 Editing of Tumor Suppressor Genes in the Mouse Endometrium Recapitulates High-Risk Endometrial Carcinoma [0.03%]
小鼠子宫内膜中肿瘤抑制基因的多重CRISPR/Cas9编辑可再现高危型子宫内膜癌
Maria Vidal-Sabanés,Raúl Navaridas,Núria Bonifaci et al.
Maria Vidal-Sabanés et al.
TIMELESS Promotes LUAD Growth via Suppressing Transferrin-Mediated Ferroptosis and Reprograms the Tumor Microenvironment against Anti-PD-1 Immunotherapy [0.03%]
TIMELess通过抑制转铁蛋白介导的铁死亡并重新编程肿瘤微环境而促进LUAD生长从而抵抗抗PD-1免疫治疗
Chenchen Hu,Feiming Hu,Changjian Shao et al.
Chenchen Hu et al.
Background: Lung cancer remains a major global health burden. RNA-binding proteins (RBPs) play crucial roles in post-transcriptional gene regulation, and their dysregulation is frequently implicated in tumorigenesis. The present study aimed...
The Spatiotemporal Heterogeneity of Tumor-Associated Stromal Cells: Reprogramming Plasticity to Unlock Precision Cancer Immunotherapy [0.03%]
肿瘤相关基质细胞的时空异质性：重编程可塑性以解锁精准癌症免疫治疗
Yingying Lv,Tingfei Duan,Jinling Song et al.
Yingying Lv et al.
Tumor-associated stromal cells (TASCs) are key architects of the tumor microenvironment (TME), playing a vital role in tumor development, metastasis, and therapeutic response. Their spatiotemporal heterogeneity, characterized by dynamic phe...
The Ly6ghigh Neutrophil Subset Dictates Breast Cancer Lung Metastasis via CD8+ T Cell Death [0.03%]
Ly6g高表达的中性粒细胞亚群通过诱导CD8⁺T细胞死亡促进乳腺癌肺转移
Rui Wang,Xiaoqi Liu,Yixuan Hou et al.
Rui Wang et al.
Background: Lung metastasis is a leading cause of breast cancer (BC)-related mortality, driven by the immunosuppressive traits of the metastatic tumor microenvironment. However, the mechanisms underlying cell-cell crosstalk in shaping immun...
Endopharyngeal Ultrasound-Guided Transpharyngeal Needle Aspiration for Confirming Retropharyngeal Lymph Nodes' Metastasis among Nasopharyngeal Carcinoma Patients [0.03%]
经内镜超声引导下经咽壁穿刺诊断鼻咽癌后组淋巴结转移的技术价值研究
Chuanbo Xie,Long-Jun He,Wencheng Tan et al.
Chuanbo Xie et al.
Tumor Microenvironment Onmyoji: Cytokines with Dual Protumor and Antitumor Roles [0.03%]
肿瘤微环境阴阳师：具有双重作用的细胞因子
Yaxuan Wang,Anqi Lin,Zaoqu Liu et al.
Yaxuan Wang et al.
Cytokines are essential components of the tumor microenvironment (TME) and play crucial roles in tumor initiation and progression. As key mediators of interactions between immune cells and tumor cells within the TME, many cytokines exhibit ...
Preoperative Chemoradiotherapy versus Chemotherapy for Locally Advanced Gastric Cancer or Gastroesophageal Junction Adenocarcinoma: A Phase III Randomized Controlled Trial from China [0.03%]
局部晚期胃癌或 gastroesophageal junction腺癌术前放化疗与化疗的多中心随机对照研究
Xiaowen Liu,Jiejie Jin,Menglong Zhou et al.
Xiaowen Liu et al.
Background: The prognostic superiority of preoperative chemoradiotherapy (pre-CRT) over preoperative chemotherapy (pre-CT) in patients with locally advanced gastric cancer remains controversial. Herein, we evaluated the efficacy and safety ...