TOPK Suppresses the CD8+ T Cell Antitumor Immunity via Modulation of IRF5 Expression
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Background: T-LAK cell-originated protein kinase (TOPK), a serine/threonine kinase, is aberrantly overexpressed in human tumors and promotes malignant proliferation. Melanoma is a highly immunogenic tumor in which CD8+ T cell-mediated cytotoxicity is usually l... ...
