Anbenitamab in combination with chemotherapy in patients with HER2-positive gastric or gastroesophageal junction carcinoma who failed previous therapy containing trastuzumab: a multicenter, phase II study (KC-WISE 01) [0.03%]
三线抗HER2胃癌及胃食管结合部癌的抗体药物安本尼单抗联合化疗的多中心II期临床研究(KC-WISE 01)
Chuanhua Zhao,Jun Zhao,Yigui Chen et al.
Chuanhua Zhao et al.
Efficacy and safety of combining bevacizumab and fractionated stereotactic radiotherapy for extensive brain metastases in patients with non-small cell lung cancer: a prospective phase II study (GASTO-1053) [0.03%]
贝伐单抗联合分次立体定向放射治疗广泛脑转移的非小细胞肺癌患者的疗效和安全性：一项前瞻性II期研究(GASTO-1053)
Rui Zhou,Shiyang Zheng,Daquan Wang et al.
Rui Zhou et al.
Background: The prognosis for non-small cell lung cancer (NSCLC) patients with extensive brain metastases (BMs) treated with radiotherapy alone remains poor. Based on the synergistic potential of radiotherapy and angiogen...
Pan-cyclin-dependent kinase inhibition is a potential treatment for adenoid cystic carcinoma that downregulates the MYB::NFIB fusion and induces tumor regression [0.03%]
泛周期素依赖性激酶抑制有可能成为腺样囊性癌的治疗方法，该抑制法下调MYB::NFIB融合并诱导肿瘤消退
Junchi Huang,Peter Larsson,Maryam Kakay Afshari et al.
Junchi Huang et al.
Unfolded protein response kinase PERK supports survival and metastasis of circulating tumor cell clusters via SAM synthesis and H3K4me3-dependent PDGFB signaling [0.03%]
未折叠蛋白反应激酶PERK通过SAM介导的组蛋白H3赖氨酸4三甲基化和PDGFB信号支持循环肿瘤细胞簇的存活及转移
Rui Tang,Yan Sun,Ao Deng et al.
Rui Tang et al.
Background: Metastasis is the leading cause of cancer-related mortality, with circulating tumor cell (CTC) clusters serving as highly efficient precursors of distant metastasis. Survival of CTC clusters in the bloodstream...
HMGB3 promotes brain metastasis of lung adenocarcinoma by recruiting SSBP1 for nuclear translocation to remodel mitochondrial metabolism [0.03%]
HMGB3通过招募SSBP1进行核易位来重塑线粒体代谢从而促进肺腺癌脑转移
Huanhuan Cui,Yuechao Yang,Sen Li et al.
Huanhuan Cui et al.
Background: Brain metastasis, a leading cause of death in patients with lung adenocarcinoma (LUAD), arises from tumor cells adapting to the unique microenvironment of the brain through metabolic remodeling regulated by ke...
A practical overview and statistical analysis of interval-censored data in cancer [0.03%]
癌症中区间截断数据的实际概述和统计分析
Tanujit Dey,Stuart Lipsitz,Zara Cooper et al.
Tanujit Dey et al.
In vivo intratumoral heterogeneity in a dish: scalable forebrain organoid models of embryonal brain tumors for high-throughput personalized drug discovery [0.03%]
一站式检测脑肿瘤异质性：体内脑瘤胚胎类器官模型的建立及高通量药物筛选应用
Nicole C Riedel,Carolin Walter,Flavia W de Faria et al.
Nicole C Riedel et al.
The INSPECTOR study: enhanced feasibility for clinical translation of a multi-cancer early detection method based on enzyme-assisted high signal-to-noise ratio sequencing of methylated circulating tumor DNA [0.03%]
INSPECTOR研究：基于酶辅助高信噪比测序甲基化循环肿瘤DNA的多癌症早期检测方法的临床转化可行性增强
Hui-Yan Luo,Wei Wei,Pansong Li et al.
Hui-Yan Luo et al.
Background: Blood-based cell-free DNA (cfDNA) methylation testing has emerged as a promising approach for multi-cancer early detection (MCED), holding the potential to improve cancer survival rates. However, traditional b...
Intranuclear paraspeckle-circular RNA TACC3 assembly forms RNA-DNA hybrids to facilitate MASH-related hepatocellular carcinoma growth in an m6A-dependent manner [0.03%]
m6A依赖的细胞核内寄生speckle-TACC3环形RNA组装形成RNA-DNA杂交体促进肝癌的发生发展
Jingbo Fu,Yanping Wei,Yun Yang et al.
Jingbo Fu et al.
Background: Metabolic dysfunction-associated steatohepatitis (MASH) is anticipated to become the leading cause of hepatocellular carcinoma (HCC). Accumulating evidence indicates that N6-methyladenosine (m6A)-modified circ...
RNA m1A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target [0.03%]
RNA m1A甲基转移酶TRMT61A通过增强ONECUT2 mRNA稳定性促进结直肠肿瘤发生并可作为潜在治疗靶点
Xiaoting Zhang,Na Qin,Fenfen Ji et al.
Xiaoting Zhang et al.
Background: The role of N1-methyladenosine (m1A) in cancer is poorly understood. Here we explored the function of RNA methyltransferase TRNA methyltransferase 61A (TRMT61A) in colorectal cancer (CRC) and its potential as ...