Accessing carbon, boron and germanium spiro stereocentres in a unified catalytic enantioselective approach [0.03%]
统一催化enantioselective方法中碳、硼和锗 Spiro 立体中心的访问
Yi-Xuan Cao,Anne-Sophie Chauvin,Shuo Tong et al.
Yi-Xuan Cao et al.
Achieving substrate generality in asymmetric catalysis remains a long-standing goal, particularly for the selective construction of chiral heteroatoms. Compared with carbon, sulfur, phosphorus and silicon stereogenic centres, methods for th...
Precision installation of silyl synthetic handles within arenes by regiocontrolled ruthenium C(sp 2)-H functionalization [0.03%]
区域可控的钌催化C(sp2)—H活化在芳环上精准安装硅基合成手性基团
Jamie H Docherty,Mishra Deepak Hareram,Luke M Nichols et al.
Jamie H Docherty et al.
The site-selective functionalization of C(sp 2)-H bonds represents a powerful strategy for the synthesis of structurally diverse compounds with broad applicability. Here we report efficient regioselective catalytic methods for the formation...
Enantioconvergent nucleophilic substitution via synergistic phase-transfer catalysis [0.03%]
协同相转移催化实现不对称转化的亲核取代反应
Claire Dooley,Francesco Ibba,Bence B Botlik et al.
Claire Dooley et al.
Catalytic enantioconvergent nucleophilic substitution reactions of alkyl halides are highly valuable transformations, but they are notoriously difficult to implement. Specifically, nucleophilic fluorination is a renowned challenge, especial...
Ammonia synthesis via an engineered nitrogenase assembly pathway in Escherichia coli [0.03%]
工程化固氮酶途径在大肠杆菌中合成氨
Joseph B Solomon,Chi Chung Lee,Yiling A Liu et al.
Joseph B Solomon et al.
Heterologous expression of nitrogenase has been actively pursued because of the far-reaching impact of this enzyme on agriculture, energy and environment. Yet, isolation of an active two-component, metallocentre-containing nitrogenase from ...
Unexpected enzyme-catalysed [4+2] cycloaddition and rearrangement in polyether antibiotic biosynthesis [0.03%]
聚醚类抗生素生物合成中的意外酶催化[4+2]环加成和重排反应
Rory Little,Fernanda C R Paiva,Rob Jenkins et al.
Rory Little et al.
Enzymes catalysing remarkable Diels-Alder-like [4+2] cyclisations have been previously implicated in the biosynthesis of spirotetronate and spirotetramate antibiotics. Biosynthesis of the polyether antibiotic tetronasin is not anticipated t...
Split cross-coupling via Rh-catalysed activation of unstrained aryl-aryl bonds [0.03%]
通过Rh催化活化非张力芳基-芳基键实现偶联交叉耦合反应
Congjun Yu,Zining Zhang,Guangbin Dong
Congjun Yu
Constructive functionalization of unstrained aryl-aryl bonds has been a fundamental challenge in organic synthesis due to the inertness of these bonds. Here we report a split cross-coupling strategy that allows two-fold arylation with diver...
Elucidating electron-transfer events in polypyridine nickel complexes for reductive coupling reactions [0.03%]
揭示多吡啶镍配合物在还原偶联反应中的电子转移过程
Craig S Day,Ángel Rentería-Gómez,Stephanie J Ton et al.
Craig S Day et al.
Polypyridine-ligated nickel complexes are widely used as privileged catalysts in a variety of cross-coupling reactions. The rapid adoption of these complexes is tentatively attributed to their ability to shuttle between different oxidation ...
Performance evaluation and multidisciplinary analysis of catalytic fixation reactions by material-microbe hybrids [0.03%]
材料-微生物杂化体系固碳性能评价与多学科分析研究进展
Xun Guan,Yongchao Xie,Chong Liu
Xun Guan
Hybrid systems that integrate synthetic materials with biological machinery offer opportunities for sustainable and efficient catalysis. However, the multidisciplinary and unique nature of the materials-biology interface requires researcher...
Ring expansion of indene by photoredox-enabled functionalized carbon-atom insertion [0.03%]
基于光氧化还原的官能团化碳原子插入诱导烯并环扩张反应
Fu-Peng Wu,Chetan C Chintawar,Remy Lalisse et al.
Fu-Peng Wu et al.
Skeletal editing has received unprecedented attention as an emerging technology for the late-stage manipulation of molecular scaffolds. The direct achievement of functionalized carbon-atom insertion in aromatic rings is challenging. Despite...
Generative machine learning produces kinetic models that accurately characterize intracellular metabolic states [0.03%]
生成式机器学习产生动力学模型准确表征细胞内代谢状态
Subham Choudhury,Bharath Narayanan,Michael Moret et al.
Subham Choudhury et al.
Generating large omics datasets has become routine for gaining insights into cellular processes, yet deciphering these datasets to determine metabolic states remains challenging. Kinetic models can help integrate omics data by explicitly li...