Interfacial Tuning of Electrocatalytic Ag Surfaces for Fragment-Based Electrophile Coupling [0.03%]
用于碎片偶联电催化剂Ag表面的界面调控
Qiu-Cheng Chen,Sarah Kress,Rocco Molinelli et al.
Qiu-Cheng Chen et al.
Construction of C‒C bonds in medicinal chemistry frequently draws on the reductive coupling of organic halides with ketones or aldehydes. Catalytic C(sp3)‒C(sp3) bond formation, however, is constrained by the competitive side reactivity o...
In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis [0.03%]
体外构建COQ代谢物揭示辅酶Q生物合成的分子决定因素
Callum R Nicoll,Laura Alvigini,Andrea Gottinger et al.
Callum R Nicoll et al.
Metabolons are protein assemblies that perform a series of reactions in a metabolic pathway. However, the general importance and aptitude of metabolons for enzyme catalysis remain poorly understood. In animals, biosynthesis of coenzyme Q is...
Enzyme-controlled stereoselective radical cyclization to arenes enabled by metalloredox biocatalysis [0.03%]
金属酶氧化生物催化控制的自由基环化到芳香族化合物的立体选择性反应
Wenzhen Fu,Natalia M Neris,Yue Fu et al.
Wenzhen Fu et al.
The effective induction of high levels of stereocontrol for free radical-mediated transformations represents a notorious challenge in asymmetric catalysis. Herein, we describe a novel metalloredox biocatalysis strategy to repurpose natural ...
Anuska Das,Jay Rai,Mitchell O Roth et al.
Anuska Das et al.
Controlling the activity of the CRISPR-Cas9 system is essential to its safe adoption for clinical and research applications. Although the conformational dynamics of Cas9 are known to control its enzymatic activity, details of how Cas9 influ...
Product analog binding identifies the copper active site of particulate methane monooxygenase [0.03%]
颗粒甲烷单加氧酶的铜活性位点的产品类似物结合鉴定
Frank J Tucci,Richard J Jodts,Brian M Hoffman et al.
Frank J Tucci et al.
Nature's primary methane-oxidizing enzyme, the membrane-bound particulate methane monooxygenase (pMMO), catalyzes the oxidation of methane to methanol. pMMO activity requires copper, and decades of structural and spectroscopic studies have ...
The catalytic role of glutathione transferases in heterologous anthocyanin biosynthesis [0.03%]
谷胱甘肽转移酶在异源花青素生物合成中的催化作用
Michael Eichenberger,Thomas Schwander,Sean Hüppi et al.
Michael Eichenberger et al.
Anthocyanins are ubiquitous plant pigments used in a variety of technological applications. Yet, after over a century of research, the penultimate biosynthetic step to anthocyanidins attributed to the action of leucoanthocyanidin dioxygenas...
Robin Girod,Timon Lazaridis,Hubert A Gasteiger et al.
Robin Girod et al.
Catalyst layers in proton exchange membrane fuel cells consist of platinum-group-metal nanocatalysts supported on carbon aggregates, forming a porous structure through which an ionomer network percolates. The local structural character of t...
Sayan Kar,Michael Rauch,Gregory Leitus et al.
Sayan Kar et al.
Formic acid (FA) is a promising hydrogen carrier which can play an instrumental role in the overall implementation of a hydrogen economy. In this regard, it is important to generate H2 gas from neat FA without any solvent/additive, for whic...
Rui Guo,Heyu Chen,Yang Yang
Rui Guo
General catalytic methods for free radical-mediated asymmetric transformations have long eluded synthetic organic chemists. Now, NAD(P)H-dependent ketoreductases (KREDs) are repurposed and engineered as highly efficient photoenzymes to cata...
Chemodivergent C(sp3)-H and C(sp2)-H Cyanomethylation Using Engineered Carbene Transferases [0.03%]
工程化卡宾转移酶介导的化学分异C(sp3)—H和C(sp2)—H氰甲基化反应
Juner Zhang,Ailiena O Maggiolo,Edwin Alfonzo et al.
Juner Zhang et al.
The ubiquity of C-H bonds presents an attractive opportunity to elaborate and build complexity in organic molecules. Methods for selective functionalization, however, often must differentiate among multiple chemically similar and, in some c...