Performance evaluation and multidisciplinary analysis of catalytic fixation reactions by material-microbe hybrids [0.03%]
材料-微生物杂化体系固碳性能评价与多学科分析研究进展
Xun Guan,Yongchao Xie,Chong Liu
Xun Guan
Hybrid systems that integrate synthetic materials with biological machinery offer opportunities for sustainable and efficient catalysis. However, the multidisciplinary and unique nature of the materials-biology interface requires researcher...
Ring expansion of indene by photoredox-enabled functionalized carbon-atom insertion [0.03%]
基于光氧化还原的官能团化碳原子插入诱导烯并环扩张反应
Fu-Peng Wu,Chetan C Chintawar,Remy Lalisse et al.
Fu-Peng Wu et al.
Skeletal editing has received unprecedented attention as an emerging technology for the late-stage manipulation of molecular scaffolds. The direct achievement of functionalized carbon-atom insertion in aromatic rings is challenging. Despite...
Generative machine learning produces kinetic models that accurately characterize intracellular metabolic states [0.03%]
生成式机器学习产生动力学模型准确表征细胞内代谢状态
Subham Choudhury,Bharath Narayanan,Michael Moret et al.
Subham Choudhury et al.
Generating large omics datasets has become routine for gaining insights into cellular processes, yet deciphering these datasets to determine metabolic states remains challenging. Kinetic models can help integrate omics data by explicitly li...
Biocatalytic, Enantioenriched Primary Amination of Tertiary C-H Bonds [0.03%]
三级C-H键的生物催化和对映 enrichment primary amination
Runze Mao,Shilong Gao,Zi-Yang Qin et al.
Runze Mao et al.
Intermolecular functionalization of tertiary C-H bonds to construct fully substituted stereogenic carbon centers represents a formidable challenge: without the assistance of directing groups, state-of-the-art catalysts struggle to introduce...
Nickel-catalysed enantioselective alkene dicarbofunctionalization enabled by photochemical aliphatic C-H bond activation [0.03%]
光化学活化烷基C-H键实现的手性镍催化烯烃双官能化反应
Xia Hu,Iván Cheng-Sánchez,Wangqing Kong et al.
Xia Hu et al.
The development of novel strategies to rapidly construct complex chiral molecules from readily available feedstocks is a long-term pursuit in the chemistry community. Radical-mediated alkene difunctionalizations represent an excellent platf...
Congested C(sp3)-rich architectures enabled by iron-catalysed conjunctive alkylation [0.03%]
铁催化联结型烷基化反应构建富碳(sp3)骨架化合物
Tong-De Tan,Juan M I Serviano,Xiaohua Luo et al.
Tong-De Tan et al.
Catalytic cross-coupling by transition metals has revolutionized the formation of C-C bonds in organic synthesis. However, the challenge of forming multiple alkyl-alkyl bonds in crowded environments remains largely unresolved. Here, we repo...
Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase [0.03%]
表型上相互作用的突变如何通过改变酶进化的速率限制步骤而产生(epistasis-arises-from-shifting-the-rate-limiting-step-during-enzyme-evolution-of-a-%CE%B2-lactamase)
Christopher Fröhlich,H Adrian Bunzel,Karol Buda et al.
Christopher Fröhlich et al.
Epistasis, the non-additive effect of mutations, can provide combinatorial improvements to enzyme activity that substantially exceed the gains from individual mutations. Yet the molecular mechanisms of epistasis remain elusive, undermining ...
A synthetic methylotrophic Escherichia coli as a chassis for bioproduction from methanol [0.03%]
一种合成型甲醇同化利用工程大肠杆菌底盘细胞用于甲醇生物制造
Michael A Reiter,Timothy Bradley,Lars A Büchel et al.
Michael A Reiter et al.
Methanol synthesized from captured greenhouse gases is an emerging renewable feedstock with great potential for bioproduction. Recent research has raised the prospect of methanol bioconversion to value-added products using synthetic methylo...
Stereoselective Construction of β-, γ-, and δ-Lactam Rings via Enzymatic C-H Amidation [0.03%]
基于酶催化的C-H氨化反应的立体选择性构建β-、γ-和δ-内酰胺环
Satyajit Roy,David A Vargas,Pengchen Ma et al.
Satyajit Roy et al.
Lactam rings are found in many biologically active natural products and pharmaceuticals, including important classes of antibiotics. Methods for the asymmetric synthesis of these molecules are therefore highly desirable, particularly throug...
Zhengyi Zhang,Jianqiang Feng,Chao Yang et al.
Zhengyi Zhang et al.
Since the discovery of Hofmann-Löffler-Freytag reaction more than 130 years ago, nitrogen-centered radicals have been widely studied in both structures and reactivities1-2. Nevertheless, catalytic enantioselective intermolecular radical hy...