CO2 electroreduction on Cu operates via an alternative chain growth mechanism to form C-C bonds at elevated temperature and pressure [0.03%]
在高温高压下二氧化碳电还原在铜上通过一种替代的链生长机制形成C-C键
Rafaël E Vos,Pengfei Sun,Daniel Schauermann et al.
Rafaël E Vos et al.
Future practical applications of the electrochemical CO2 reduction reaction will probably involve the use of higher pressures and temperatures. However, most research on the copper-catalysed electrochemical CO2 reduction reaction-the most w...
Enantioconvergent copper-catalysed difluoromethylation of alkyl halides [0.03%]
铜催化下烷基卤化物的差向异构收敛型二氟甲基化反应
Decai Ding,Lingfeng Yin,Andrew T Poore et al.
Decai Ding et al.
Stereochemically controlled hydrogen bond donors play essential roles in the pharmaceutical industry. Consequently, organic molecules that bear difluoromethyl (CF2H) groups at chiral centres are emerging as pivotal components in pharmaceuti...
Qingjin Liang,Xinping Zhang,Madeline E Rotella et al.
Qingjin Liang et al.
Sulfur-stereogenic molecules have a significant impact on drug development, but are underexplored largely due to our limited ability to construct such structures. Among them, sulfilimines are a class of chiral molecules bearing S(IV)-stereo...
Bismuth-photocatalysed Heck-type coupling with alkyl and aryl electrophiles [0.03%]
铋光催化与烷基和芳基亲电子试剂的 heck 类偶联反应
Shengyang Ni,Alexios Stamoulis,Vanessa A Béland et al.
Shengyang Ni et al.
The Heck reaction, which is widely used for the construction of C‒C bonds, is a cornerstone of modern organic synthesis. Traditionally, this transformation relies on transition metal catalysts, whose frontier d-orbitals cement the mechanis...
De novo design and evolution of an artificial metathase for cytoplasmic olefin metathesis [0.03%]
从头设计并进化出一种用于细胞内烯烃复分解的人工酶
Zhi Zou,Indrek Kalvet,Boris Lozhkin et al.
Zhi Zou et al.
Artificial metalloenzymes present a promising avenue for abiotic catalysis within living systems. However, their in vivo application is currently limited by critical challenges, particularly in selecting suitable protein scaffolds capable o...
Methylthio-alkane reductases use nitrogenase metalloclusters for carbon-sulfur bond cleavage [0.03%]
甲基硫代烷烃还原酶利用氮固定金属簇裂解碳硫键
Ana Lago-Maciel,Jéssica C Soares,Jan Zarzycki et al.
Ana Lago-Maciel et al.
Methylthio-alkane reductases convert methylated sulfur compounds to methanethiol and small hydrocarbons, a process with important environmental and biotechnological implications. These enzymes are classified as nitrogenase-like enzymes, des...
Enantioselective Radical Dearomative Conjugate Amination Enabled by Co(II)-Based Metalloradical Catalysis [0.03%]
手性Co(II)金属自由基催化体系介导的去芳构化共轭氨基化反应
Pan Xu,Duo-Sheng Wang,Zhenyu Zhu et al.
Pan Xu et al.
Delocalized radical systems present a challenging yet appealing ground to test the control of multiple selectivity in organic synthesis. Despite some recent advancements, the issue of regioselectivity in delocalized radical system has large...
A modular synthesis of azetidines from reactive triplet imine intermediates using an intermolecular aza Paternò-Büchi reaction [0.03%]
一个使用分子间aza Paternò-Büchi反应合成反应性三重态亚胺中间体的氮杂环丁烷模块化合成方法
Benedict A Williams,Michael J Tilby,Nicholas A Parker et al.
Benedict A Williams et al.
Azetidines are four-membered saturated N-heterocycles that are of interest in discovery chemistry. However, the implementation of these structures is limited by their synthetic intractability, resulting from their inherent ring strain. An a...
Enantioselective Pd-Catalysed Nucleophilic C(sp3)-H (Radio)fluorination [0.03%]
钯催化对映选择性亲核C(sp3)-H氟（放射）化反应
Nikita Chekshin,Luo-Yan Liu,D Quang Phan et al.
Nikita Chekshin et al.
Despite increasing demand for chiral fluorinated organic molecules, enantioselective C-H fluorination remains among the most challenging and sought-after transformations in organic synthesis. Furthermore, utilizing nucleophilic sources of f...
Zuodong Sun,Xin Zang,Qingyang Zhou et al.
Zuodong Sun et al.
Iminium-catalyzed cycloaddition is one of the most prominent examples of organocatalysis, yet a biological counterpart has not been reported despite the wide-spread occurrence of iminium adducts in enzymes. Here, we present biochemical, str...