Bismuth-photocatalysed Heck-type coupling with alkyl and aryl electrophiles [0.03%]
铋光催化与烷基和芳基亲电子试剂的 heck 类偶联反应
Shengyang Ni,Alexios Stamoulis,Vanessa A Béland et al.
Shengyang Ni et al.
The Heck reaction, which is widely used for the construction of C‒C bonds, is a cornerstone of modern organic synthesis. Traditionally, this transformation relies on transition metal catalysts, whose frontier d-orbitals cement the mechanis...
De novo design and evolution of an artificial metathase for cytoplasmic olefin metathesis [0.03%]
从头设计并进化出一种用于细胞内烯烃复分解的人工酶
Zhi Zou,Indrek Kalvet,Boris Lozhkin et al.
Zhi Zou et al.
Artificial metalloenzymes present a promising avenue for abiotic catalysis within living systems. However, their in vivo application is currently limited by critical challenges, particularly in selecting suitable protein scaffolds capable o...
Methylthio-alkane reductases use nitrogenase metalloclusters for carbon-sulfur bond cleavage [0.03%]
甲基硫代烷烃还原酶利用氮固定金属簇裂解碳硫键
Ana Lago-Maciel,Jéssica C Soares,Jan Zarzycki et al.
Ana Lago-Maciel et al.
Methylthio-alkane reductases convert methylated sulfur compounds to methanethiol and small hydrocarbons, a process with important environmental and biotechnological implications. These enzymes are classified as nitrogenase-like enzymes, des...
Enantioselective Radical Dearomative Conjugate Amination Enabled by Co(II)-Based Metalloradical Catalysis [0.03%]
手性Co(II)金属自由基催化体系介导的去芳构化共轭氨基化反应
Pan Xu,Duo-Sheng Wang,Zhenyu Zhu et al.
Pan Xu et al.
Delocalized radical systems present a challenging yet appealing ground to test the control of multiple selectivity in organic synthesis. Despite some recent advancements, the issue of regioselectivity in delocalized radical system has large...
A modular synthesis of azetidines from reactive triplet imine intermediates using an intermolecular aza Paternò-Büchi reaction [0.03%]
一个使用分子间aza Paternò-Büchi反应合成反应性三重态亚胺中间体的氮杂环丁烷模块化合成方法
Benedict A Williams,Michael J Tilby,Nicholas A Parker et al.
Benedict A Williams et al.
Azetidines are four-membered saturated N-heterocycles that are of interest in discovery chemistry. However, the implementation of these structures is limited by their synthetic intractability, resulting from their inherent ring strain. An a...
Enantioselective Pd-Catalysed Nucleophilic C(sp3)-H (Radio)fluorination [0.03%]
钯催化对映选择性亲核C(sp3)-H氟（放射）化反应
Nikita Chekshin,Luo-Yan Liu,D Quang Phan et al.
Nikita Chekshin et al.
Despite increasing demand for chiral fluorinated organic molecules, enantioselective C-H fluorination remains among the most challenging and sought-after transformations in organic synthesis. Furthermore, utilizing nucleophilic sources of f...
Zuodong Sun,Xin Zang,Qingyang Zhou et al.
Zuodong Sun et al.
Iminium-catalyzed cycloaddition is one of the most prominent examples of organocatalysis, yet a biological counterpart has not been reported despite the wide-spread occurrence of iminium adducts in enzymes. Here, we present biochemical, str...
Radical S-adenosyl-l-methionine FeS cluster implicated as the sulfur donor during albomycin biosynthesis [0.03%]
含硫辅因子的激进型S-腺苷蛋氨酸铁硫簇在白霉素生物合成中作为供硫底物的可能性
Richiro Ushimaru,Ziyang Zheng,Jin Xiong et al.
Richiro Ushimaru et al.
Carbon-sulfur bond-forming reactions in natural product biosynthesis largely involve Lewis acid/base chemistry with relatively few examples catalysed by radical S-adenosyl-l-methionine (SAM) enzymes. The latter have been limited to radical-...
Mechanistic and structural characterization of an iridium-containing cytochrome reveals kinetically relevant cofactor dynamics [0.03%]
机理和结构表征含铱细胞色素揭示动力学相关辅因子动态特性
Brandon J Bloomer,Sean N Natoli,Marc Garcia-Borràs et al.
Brandon J Bloomer et al.
Artificial metalloenzymes (ArMs), which contain non-native, typically synthetic, metal cofactors, are a flourishing class of biocatalyst for unnatural reactions. Although the number of these reactions is rapidly increasing, multi-faceted me...
Ligand binding to a Ni-Fe cluster orchestrates conformational changes of the CO-dehydrogenase-acetyl-CoA synthase complex [0.03%]
配体与一个Ni-Fe簇结合 调节CO脱氢酶-乙酰辅酶A合成酶复合物的构象变化
Jakob Ruickoldt,Julian Kreibich,Thomas Bick et al.
Jakob Ruickoldt et al.
Catalytic metal clusters play critical roles in important enzymatic pathways such as carbon fixation and energy conservation. However, how ligand binding to the active-site metal regulates conformational changes critical for enzyme function...