Ruth Ganss
Ruth Ganss
Tumour growth critically depends on a supportive microenvironment, including the tumour vasculature. Tumour blood vessels are structurally abnormal and functionally anergic which limits drug access and immune responses in solid cancers. Thu...
Makeda Stephenson,Daniel H Reich,Kenneth R Boheler
Makeda Stephenson
The reproducible generation of human-induced pluripotent stem cell (hiPSC)-derived vascular smooth muscle cells (vSMCs) in vitro has been critical to overcoming many limitations of animal and primary cell models of vascular biology and dise...
The vascular epigenome in patients with obesity and type 2 diabetes: opportunities for personalized therapies [0.03%]
肥胖和二型糖尿病患者的血管表观基因组：个性化治疗的机遇
Sarah Costantino,Shafeeq A Mohammed,Samuele Ambrosini et al.
Sarah Costantino et al.
Our genetic background provides limited information on individual risk of developing vascular complications overtime. New biological layers, namely epigenetic modifications, are now emerging as potent regulators of gene expression thus lead...
Immune cell trafficking across the blood-brain barrier in the absence and presence of neuroinflammation [0.03%]
在神经炎症不存在和存在的情况下免疫细胞穿越血脑屏障的过程
Luca Marchetti,Britta Engelhardt
Luca Marchetti
To maintain the homeostatic environment required for proper function of CNS neurons the endothelial cells of CNS microvessels tightly regulate the movement of ions and molecules between the blood and the CNS. The unique properties of these ...
Cardiovascular complications of COVID-19: evidence, misconceptions, and new opportunities [0.03%]
COVID-19的心血管并发症：证据、误解和新机遇
Paolo Madeddu
Paolo Madeddu
Amer Harky,Ka Siu Fan,Ka Hay Fan
Amer Harky
Thoracic aortic aneurysms and aortic dissections (TAAD) are highly fatal emergencies within cardiothoracic surgery. With increasing age, thoracic aneurysms become more prevalent and pose an even greater threat when they develop into aortic ...
GPCR transactivation signalling in vascular smooth muscle cells: role of NADPH oxidases and reactive oxygen species [0.03%]
血管平滑肌细胞中的GPCR转激活信号：NADPH氧化酶和活性氧的作用
Raafat Mohamed,Reearna Janke,Wanru Guo et al.
Raafat Mohamed et al.
The discovery and extension of G-protein-coupled receptor (GPCR) transactivation-dependent signalling has enormously broadened the GPCR signalling paradigm. GPCRs can transactivate protein tyrosine kinase receptors (PTKRs) and serine/threon...
Eleonora Zucchelli,Qasim A Majid,Gabor Foldes
Eleonora Zucchelli
Angiogenesis and vasculogenesis are complex processes by which new blood vessels are formed and expanded. They play a pivotal role not only in physiological development and growth and tissue and organ repair, but also in a range of patholog...
Piotr Kobialka,Mariona Graupera
Piotr Kobialka
PI3Ks belong to a family of lipid kinases that comprises eight isoforms. They phosphorylate the third position of the inositol ring present in phosphatidylinositol lipids and, in turn, activate a broad range of proteins. The PI3K pathway re...