Modeling smooth muscle cell endothelial cell crosstalk in abdominal aortic aneurysms using 3D microvessels on-chip [0.03%]
基于芯片上的三维微血管的主动脉瘤平滑肌细胞内皮细胞相互作用建模仿真研究
Philipp C Hauger,Karlijn B Rombouts,Marc Vila Cuenca et al.
Philipp C Hauger et al.
Abdominal aortic aneurysms (AAA) are pathological dilations of the abdominal aorta. To date, surgical intervention is the only option for managing large AAAs, with no pharmacological therapies to prevent growth of small aneurysms. A current...
Trophoblast invasion biology: from normal implantation to accreta spectrum and choriocarcinoma [0.03%]
滋养层侵袭生物学：从正常植入到胎盘过度浸润谱系和绒毛膜癌
Mishu Mangla,Rohini Motwani,Seetu Palo et al.
Mishu Mangla et al.
Trophoblast invasion is a finely regulated physiological process that demonstrates controlled cellular migration and vascular remodeling during human pregnancy. During normal implantation, cytotrophoblasts differentiate into extravillous tr...
Jeffrey Kroon,Ilse Timmerman,Ilkka Paatero et al.
Jeffrey Kroon et al.
Endothelial cells lining the vessel wall are instrumental in angiogenesis. They initiate this process and remodel their actin cytoskeleton to facilitate proliferation and migration from pre-existing vessels. However, the mechanisms that coo...
Comparative analysis of BMP signaling in human ECFCs reveals vascular bed-dependent ALK2 expression [0.03%]
人源ECFC中BMP信号的比较分析揭示血管床依赖性的ALK2表达
Nadine Z Großmann,Nurcan Haştar,Yunyun Xiao et al.
Nadine Z Großmann et al.
Bone morphogenetic protein (BMP) signaling pathway components play a crucial role in cardiovascular homeostasis and sprouting angiogenesis. Endothelial colony-forming cells (ECFCs) are endothelial progenitor cells with high proliferative an...
Myeloid HIF-1α has only a minor impact on atherosclerosis development [0.03%]
髓系HIF-1α在动脉粥样硬化发展中的作用微乎其微
Nathalie Dehne,Katrin Schröder
Nathalie Dehne
Atherosclerosis is a progressive inflammatory disease which initiation and progression are potentially mediated by myeloid cells. An imbalance of oxygen supply and therefore hypoxic situations in the arterial wall have been hypothesized to ...
Vessels in Middle-Earth: Meeting Report from the 2025 Australasian Summit on Vascular Biology and Microcirculation [0.03%]
中土世界中的血管：2025年澳大利亚和大洋洲血管生物学与微循环会议回顾
Kazuhide S Okuda,Amy A Baxter,Christopher P Stanley et al.
Kazuhide S Okuda et al.
The 2025 Australasian Summit on Vascular Biology and Microcirculation, jointly hosted by the Australian Vascular Biology Society (AVBS) and the Australian and New Zealand Microcirculation Society (ANZMS), convened in Queenstown, New Zealand...
Under pressure: integrated endothelial cell response to hydrostatic and shear stresses [0.03%]
压应力下的血管内皮细胞综合压力响应机制研究
Christian J Mandrycky,Takashi Ishida,Taylor Merkel et al.
Christian J Mandrycky et al.
Blood flow within the vasculature is a critical determinant of endothelial cell (EC) identity and functionality, yet the intricate interplay of various hemodynamic forces and their collective impact on endothelial and vascular responses are...
Methylarginine Levels and Their Impact on Vascular Aging: A Systematic Review [0.03%]
甲基精氨酸水平及其对血管衰老的影响：系统性综述
Eduardo Eric Almeida do Carmo,Roberta Melquiades Silva de Andrade,Celia Cristina Diogo Ferreira
Eduardo Eric Almeida do Carmo
Vascular aging is a multifactorial process characterized by structural and functional changes that compromise endothelial homeostasis and increase the risk of cardiovascular disease. Among the factors involved in this process, methylarginin...
sFlt-1/PlGF and Beyond: Angiolymphatic-Associated Signatures and Emerging Biomarkers in Placental Pathology [0.03%]
胎盘病理学中的血管淋巴标志物和新兴生物标志物：sFlt-1/PlGF之外
Dr Seetu Palo,Dr Mishu Mangla,Dr Rohini Motwani
Dr Seetu Palo
The placenta is a highly vascularized organ that depends on tightly regulated angiolymphatic networks to sustain normal fetal growth and maternal adaptation to pregnancy. Disruption of these pathways contributes to major obstetric complicat...
Integrating Endothelium-Derived Hyperpolarization, Nitric Oxide, and Prostacyclin Pathways: The Multimodal Potential of Human Tissue Kallikrein-1 [0.03%]
人组织激肽原酶1的多功能性：内皮衍生高极化、一氧化氮和前列环素途径的整合
Paolo Madeddu,Styliani Goulopoulou,David Wambeke
Paolo Madeddu
Endothelial cells regulate vascular tone by releasing nitric oxide (NO) and prostacyclin (PGI2), as well as by initiating hyperpolarization of vascular smooth muscle cells through K+ channels and myoendothelial coupling. This review highlig...