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GPCR transactivation signalling in vascular smooth muscle cells: role of NADPH oxidases and reactive oxygen species

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The discovery and extension of G-protein-coupled receptor (GPCR) transactivation-dependent signalling has enormously broadened the GPCR signalling paradigm. GPCRs can transactivate protein tyrosine kinase receptors (PTKRs) and serine/threonine kinase receptors... ...