Lack of intracranial atherosclerosis in various atherosclerotic mouse models [0.03%]
动脉粥样硬化小鼠模型中缺乏颅内动脉粥样硬化病变
Diewertje Ilse Bink,Katja Ritz,Claire Mackaaij et al.
Diewertje Ilse Bink et al.
Background: Although mice are used extensively to study atherosclerosis of different vascular beds, limited data is published on the occurrence of intracranial atherosclerosis. Since intracranial atherosclerosis is a comm...
Protection of liver sinusoidal endothelial cells using different preservation solutions [0.03%]
不同保存液对肝窦内皮细胞的保护作用
Julia Houtzager,Anne-Marieke D van Stalborch,Charlotte Hofstee et al.
Julia Houtzager et al.
Objective: Donor liver preservation methods and solutions have evolved over the last years. Liver sinusoidal endothelial cell (LSEC) barrier function and integrity during preservation is crucial for outcomes of liver tran...
Whole-body insulin resistance leads to accelerated atherosclerosis: role for Nox2 NADPH oxidase [0.03%]
全身胰岛素抵抗导致动脉粥样硬化加速：Nox2 NADPH氧化酶的作用
Azhar Maqbool,Hema Viswambharan,Anna Skromna et al.
Azhar Maqbool et al.
Insulin resistance underpins the progression of type 2 diabetes mellitus and leads to a collection of risk factors for the development of atherosclerosis. Whether or not insulin resistance at a whole-body level per se leads to accelerated a...
Therapeutic angiogenesis for patients with chronic limb-threatening ischemia: promising or hoax? [0.03%]
慢性肢体缺血患者的治疗性血管生成：前景还是骗局？
Judith A H M Peeters,Abbey Schepers,Jaap F Hamming et al.
Judith A H M Peeters et al.
Chronic limb-threatening ischemia (CLTI) is a critical end-stage disease that leads to high amputation rates. Over the past few decades, therapeutic angiogenesis has attracted a lot of attention as a means to reduce the necessity for amputa...
Ang II-induced contraction is impaired in the aortas of renovascular hypertensive animal model [0.03%]
血管紧张素Ⅱ诱导的收缩在肾血管性高血压动物模型腹主动脉中的作用受损现象研究
Bernah M Fahning,Simone R Potje,Tiago D Paula et al.
Bernah M Fahning et al.
Abstract: Renin-angiotensin system plays a critical role in blood pressure control, and the abnormal activation of the AT1 receptor contributes to the development of renovascular hypertension. This study aimed to evaluate...
GPX4 overexpression does not alter atherosclerotic plaque development in ApoE knock-out mice [0.03%]
GPX4过表达不会改变ApoE敲除小鼠的动脉粥样硬化斑块的发展
Isabelle Coornaert,Annelies Breynaert,Nina Hermans et al.
Isabelle Coornaert et al.
Ferroptosis is a type of regulated necrosis that is associated with iron-dependent accumulation of lipid hydroperoxides. Given that iron deposition and lipid peroxidation initiate ferroptosis in atherosclerosis and contribute to further pla...
α-Tocopherol inhibits atherogenesis and improves cardiac function in mice independently of its antioxidant properties [0.03%]
α-生育酚通过其抗氧化特性独立抑制动脉粥样硬化并改善小鼠心脏功能
Isabelle Coornaert,Annelies Breynaert,Nina Hermans et al.
Isabelle Coornaert et al.
The impact of α-tocopherol on atherosclerosis is unclear and controversial. While some studies suggest potential benefits, such as antioxidant properties that may reduce oxidative stress, other studies indicate no significant preventive ef...
Atherosclerosis: an overview of mouse models and a detailed methodology to quantify lesions in the aortic root [0.03%]
动脉粥样硬化：小鼠模型概述及详细量化主动脉根部病灶的方法
Jamie I van der Vaart,Robin van Eenige,Patrick C N Rensen et al.
Jamie I van der Vaart et al.
Cardiovascular disease, the primary cause of human mortality globally, is predominantly caused by a progressive disorder known as atherosclerosis. Atherosclerosis refers to the process of accumulation of cholesterol-enriched lipoproteins an...
Sarah Schnabellehner,Marle Kraft,Hans Schoofs et al.
Sarah Schnabellehner et al.
Endothelial cells (ECs) of blood and lymphatic vessels have distinct identity markers that define their specialized functions. Recently, hybrid vasculatures with both blood and lymphatic vessel-specific features have been discovered in mult...
Should aspirin be replaced with ADP blockers and anti-GPVI to manage thrombosis? [0.03%]
应将阿司匹林替换为ADP受体拮抗剂和抗GPVI来预防血栓形成吗？
Hafsa Khan,Tahira Ghulam,Naseer Ahmed et al.
Hafsa Khan et al.
Platelets have a pivotal role in maintaining cardiovascular homeostasis. They are kept docile by endothelial-derived mediators. Aberration in haemostatic balance predisposes an individual to an elevated risk of a prothrombotic environment. ...