Getting in Touch Is an Important Step: Control of Metabolism at Organelle Contact Sites [0.03%]
携手才能共赢：调控代谢的细胞器接触位点机制
Robin W Klemm
Robin W Klemm
Metabolic pathways are often spread over several organelles and need to be functionally integrated by controlled organelle communication. Physical organelle contact-sites have emerged as critical hubs in the regulation of cellular metabolis...
Interactome Analysis of the ER Stress Sensor Perk Uncovers Key Components of ER-Mitochondria Contact Sites and Ca2+ Signalling [0.03%]
对内质网压力传感器PERK的互作组分析揭示了内质网-线粒体接触部位和钙离子信号转导的关键成分
Maria Livia Sassano,Rita Derua,Etienne Waelkens et al.
Maria Livia Sassano et al.
We recently reported that the ER stress kinase PERK regulates ER-mitochondria appositions and ER- plasma membrane (ER-PM) contact sites, independent of its canonical role in the unfolded protein response. PERK regulation of ER-PM contacts w...
A Glimpse of the Structural Biology of the Metabolism of Sphingosine-1-Phosphate [0.03%]
ceramide 1磷酸代谢的结构生物学一瞥
Ruobing Ren,Bin Pang,Yufei Han et al.
Ruobing Ren et al.
As a key sphingolipid metabolite, sphingosine-1-phosphate (S1P) plays crucial roles in vascular and immune systems. It regulates angiogenesis, vascular integrity and homeostasis, allergic responses, and lymphocyte trafficking. S1P is interc...
Regulation of Plasma Membrane Sterol Homeostasis by Nonvesicular Lipid Transport [0.03%]
非囊泡脂质运输调节质膜固醇稳态
Dylan Hong Zheng Koh,Yasunori Saheki
Dylan Hong Zheng Koh
Sterol contributes to the structural integrity of cellular membranes and plays an important role in the regulation of cell signaling in eukaryotes. It is either produced in the endoplasmic reticulum or taken up from the extracellular enviro...
Mutant VAPB: Culprit or Innocent Bystander of Amyotrophic Lateral Sclerosis? [0.03%]
突变VAPB：运动神经元病的罪魁祸首还是无辜旁观者？
Nica Borgese,Francesca Navone,Nobuyuki Nukina et al.
Nica Borgese et al.
Nearly twenty years ago a mutation in the VAPB gene, resulting in a proline to serine substitution (p.P56S), was identified as the cause of a rare, slowly progressing, familial form of the motor neuron degenerative disease Amyotrophic Later...
Corrigendum to "Getting in Touch is an Important Step: Control of Metabolism at Organelle Contact Sites" [0.03%]
关于“互动是重要的一步： organelle接触位点上的代谢控制”的更正
[This corrects the article DOI: 10.1177/2515256421993708.]. © The Author(s) 2021.
Emerging Evidence for cAMP-calcium Cross Talk in Heart Atrial Nanodomains Where IP3-Evoked Calcium Release Stimulates Adenylyl Cyclases [0.03%]
心房纳米域中cAMP-钙信号交叉 talk 的新兴证据，其中IP3诱发的钙释放刺激腺苷酸环化酶
Rebecca-Ann B Burton,Derek A Terrar
Rebecca-Ann B Burton
Calcium handling is vital to normal physiological function in the heart. Human atrial arrhythmias, eg. atrial fibrillation, are a major morbidity and mortality burden, yet major gaps remain in our understanding of how calcium signaling path...
The Endoplasmic Reticulum-Mitochondria Encounter Structure and its Regulatory Proteins [0.03%]
内质网-线粒体接触结构及其调控蛋白
Javairia Y Cheema,Jiajia He,Wenfan Wei et al.
Javairia Y Cheema et al.
In fungi, the endoplasmic reticulum-mitochondria encounter structure (ERMES) is present between the endoplasmic reticulon (ER) and mitochondria to promote the formation of the ER-mitochondria contact sites. Four constitutive components (Mmm...
Impact of Intrinsic and Extrinsic Factors on Cellular Sphingomyelin Imaging with Specific Reporter Proteins [0.03%]
影响细胞鞘磷脂特异性报告蛋白成像的内在和外在因素分析
Toshihide Kobayashi,Nario Tomishige,Takehiko Inaba et al.
Toshihide Kobayashi et al.
Sphingomyelin (SM) is a major sphingolipid in mammalian cells. Although SM is enriched in the outer leaflet of the cell plasma membrane, lipids are also observed in the inner leaflet of the plasma membrane and intracellular organelles such ...