Gene expression profiling of peripheral blood and endometrial cancer risk factors: Systems epidemiology approach in the NOWAC Postgenome Cohort Study [0.03%]
基于人群的系统流行病学方法在挪威妇女和癌症队列研究中外周血基因表达谱与子宫内膜癌风险因素的关系探究
Oxana Gavriluk,Igor Snapkow,Jean-Christophe Thalabard et al.
Oxana Gavriluk et al.
The increasing incidence of endometrial cancer (EC) requires an extensive search for novel preventive tools and early intervention approaches. However, the establishment of reliable predictive models is impossible without knowledge of genet...
Genetic Determinants of Creatine Bioavailability and Responsiveness: Emphasis on Common Low-Impact Variants [0.03%]
creatine生物利用度和反应性的遗传决定因素：常见低影响变异的强调
Sergej M Ostojic,Ivana Kavecan
Sergej M Ostojic
Background: Creatine is a central regulator of cellular energy homeostasis and one of the most extensively studied dietary supplements in human nutrition. Although creatine supplementation consistently increases tissue cr...
Inflammatory proteins mediate the causal association between sleep traits and breast cancer: a Mendelian randomization study [0.03%]
炎性蛋白介导睡眠特征和乳腺癌之间的因果关联：一项孟德尔随机化研究
Jiawei Zhou,Lijun Mao
Jiawei Zhou
Background: Breast cancer (BC) is the most frequent cancer in women, driven by a combination of genetic, environmental, and lifestyle factors. Whether modifiable sleep behaviors causally affect BC risk remains unclear. ...
In the article by Sierra-Ruelas et al. entitled "Uncoupling Proteins Variants Are Linked to Hypercholesterolemia and Abdominal Obesity in Metabolically Unhealthy Women" [Lifestyle Genomics. 2025;18:27-35; https://doi.org/10.1159/000543484],...
Published Erratum
Lifestyle genomics. 2025;18(1):137. DOI:10.1159/000547940 2025
Dairy product intake alters the correlations between circulating bile acids and short-chain fatty acids with the bacterial taxa Roseburia, Faecalibacterium, Flavonifractor and Verrucomicrobia [0.03%]
乳制品摄入量改变了循环中的胆汁酸和短链脂肪酸与Roseburia、Faecalibacterium、Flavonifractor和Verrucomicrobia菌群之间的相关性
Atena Mahdavi,Karine Greffard,Jocelyn Trottier et al.
Atena Mahdavi et al.
Introduction: Type 2 diabetes (T2D) risk factors are associated with gut microbiota dysregulation that can alter circulating metabolites levels such as bile acids (BAs) and short-chain fatty acids (SCFAs). The objective i...
Joo Yeon Lusia Lee
Joo Yeon Lusia Lee
The Body Mass Index (BMI) is a limited tool for assessing metabolic risk, as it fails to capture the metabolic heterogeneity seen in phenotypes like metabolically healthy obesity (MHO) and metabolically unhealthy normal weight (MUNW). This ...
Body Mass Index and Interindividual Variation in Salivary Amylase Gene Copy Number Assessed Using an In-House Validated Method: A Pilot Study from the National Nutrition Survey of a High Rice-Consuming Nation [0.03%]
基于家庭验证方法评估体质指数与个体淀粉酶基因拷贝数变异的相关性：一项针对高食米国国民营养调查的试点研究
Mark Pretzel Zumaraga,Marietta Rodriguez,Charmaine Duante et al.
Mark Pretzel Zumaraga et al.
Introduction: The AMY1 gene, which encodes salivary amylase, exhibits copy number variation (CNV) that affects starch metabolism and may influence obesity risk. This study aimed to assess AMY1 CNV among selected participa...
Molecular Insights into the Functional Roles of Variants in the FADS gene cluster on Omega-3 Long-Chain Polyunsaturated Fatty Acid Synthesis [0.03%]
FADS基因簇变异影响Omega-3长链多不饱和脂肪酸合成的分子机制研究
Makaila Coulson,David M Mutch
Makaila Coulson
Omega-3 long-chain polyunsaturated fatty acids (n3-LCPUFA) have strong triglyceride-lowering and anti-inflammatory properties, and high levels of these fatty acids have been associated with reduced risk of cardiovascular disease. The synthe...
Impact of hypoxia-inducible factor-1α (HIF1α) gene polymorphisms on renal cell carcinoma susceptibility in a Chinese Han population [0.03%]
缺氧诱导因子-1α（HIF1α）基因多态性对中国汉族人群肾细胞癌易感性的影響研究
Xinxin Liao,Haibin Zhou,Peng Huang
Xinxin Liao
Objective: Previous studies have reported the impact of hypoxia inducible factor 1α (HIF1α) gene on risk of renal cell carcinoma (RCC). However, the results of these previous studies were inconsistent. Hence, this study...
Klotho, Kidneys and Micronutrient Signaling, a Promising Paradigm for Healthy Aging [0.03%]
克洛斯蛋白、肾脏与微量元素信号转导：健康老龄化的前景范式
Sara Mahdavi
Sara Mahdavi
Klotho, a transmembrane protein with pleiotropic anti-aging properties, is increasingly recognized as a central regulator of longevity and metabolic resilience. Primarily expressed in the kidneys and brain, Klotho governs phosphate and calc...