Searching for biological processes as targets for rheumatoid arthritis targeted therapy with ANDSystem, an integrated software and information platform [0.03%]
运用AND系统软件和信息平台寻找生物过程作为类风湿性关节炎靶向治疗的靶点
E L Mishchenko,I V Yatsyk,P S Demenkov et al.
E L Mishchenko et al.
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by joint involvement with progressive destruction of cartilage and bone tissue. To date, RA remains an incurable disease that leads to a significant deterior...
Linking hierarchical classification of transcription factors by the structure of their DNA-binding domains to the variability of their binding site motifs [0.03%]
通过其DNA结合域的结构将转录因子的层次分类与其结合位点基序的变化性联系起来
V G Levitsky,T Yu Vatolina,V V Raditsa
V G Levitsky
De novo motif search is the main approach for determining the nucleotide specificity of binding of the key regulators of gene transcription, transcription factors (TFs), based on data from massive genome-wide sequencing of their binding sit...
Self-learning virtual organisms in a physics simulator: on the optimal resolution of their visual system, the architecture of the nervous system and the computational complexity of the problem [0.03%]
物理模拟器中的自学习虚拟生物体：关于其视觉系统的最佳分辨率、神经系统结构以及该问题的计算复杂度
M S Zenin,A P Devyaterikov,A Yu Palyanov
M S Zenin
Vision plays a key role in the lives of various organisms, enabling spatial orientation, foraging, predator avoidance and social interaction. In species with relatively simple visual systems, such as insects, effective behavioral strategies...
Asymmetry of nucleotide substitutions in tRNAs indicates common descent of modern organisms from a thermophilic ancestor [0.03%]
tRNA中核苷酸替代的非对称性表明现代生物源自嗜热祖先
I I Titov
I I Titov
The nature of the last universal common ancestor (LUCA) of all living organisms remains a controversial issue in biology. There is evidence of both thermophilic and mesophilic LUCA origin. The increasing complexity of the cellular apparatus...
In silico reconstruction of the gene network for cytokine regulation of ASD-associated genes and proteins [0.03%]
基于计算的细胞因子调控自闭症基因及蛋白网络的重建
N M Levanova,E G Vergunov,A N Savostyanov et al.
N M Levanova et al.
Accumulated evidence links dysregulated cytokine signaling to the pathogenesis of autism spectrum disorder (ASD), implicating genes, proteins, and their intermolecular networks. This paper systematizes these findings using bioinformatics an...
Assessing the dependence of brain activity on individual single-nucleotide variability of genetic markers of major depressive disorder using principal component analysis [0.03%]
基于抑郁症重大遗传标记的单核苷酸多态性个体差异的主要成分分析脑活动依赖性
K A Zorina,A A Kriveckiy,V S Karmanov et al.
K A Zorina et al.
Major depressive disorder (MDD) is one of the most widespread mental illnesses, which necessitates the search for factors of increased predisposition to this disorder. Single nucleotide polymorphisms in genes of the brain's neurotransmitter...
E V Ignatieva,P S Demenkov,A G Bogomolov et al.
E V Ignatieva et al.
Reconstruction and analysis of gene networks regulating biological processes are among the modern methodological approaches for studying complex biological systems that ensure the vital activity of organisms. Thermoregulation is an importan...
PlantReg 1.1 identifies the mutual arrangement of transcription factor binding sites in the target promoters for the elucidation of molecular mechanisms within regulatory networks [0.03%]
植物调控元件1. 1识别转录因子结合位点在目标启动子中的相互排列以阐明调节网络内的分子机制
V V Lavrekha,N A Omelyanchuk,A G Bogomolov et al.
V V Lavrekha et al.
The development of high-throughput sequencing has expanded the possibilities for studying the regulation of gene expression, including the reconstruction of gene regulatory networks and transcription factor regulatory networks (TFRNs). Iden...
I R Grin,D O Zharkov
I R Grin
DNA oxidation is one of the main types of damage to the genetic material of living organisms. Of the many dozens of oxidative lesions, the most abundant is 8-oxoguanine (8-oxoG), a premutagenic base that leads to G→T transversions during r...
N I Melchenko,I R Akberdin
N I Melchenko
Mathematical models represent a powerful theoretical tool for studying complex biological systems. They provide an opportunity to track non-obvious interactions and conduct in silico experiments to address practical problems. Iron plays a k...