Alembic: a framework for converting disparate biological data into structured resources [0.03%]
Alembic：一种转换纷繁生物数据成为结构化资源的框架
I V Bezdvornykh,K I Yuditskiy,N A Cherkasov et al.
I V Bezdvornykh et al.
The imperative to re-analyze existing public sequencing data is central to modern biology, driven by new hypotheses and advanced analytical methods. However, this effort is critically hampered by the profound heterogeneity of repository dat...
S I Bartsev
S I Bartsev
The question on the reproducibility of evolutionary processes is primarily of fundamental importance; however, with the development of methods for modeling evolutionary processes on computer multilevel models, an answer to this question is ...
I V Zorkoltseva,N M Belonogova,A V Kirichenko et al.
I V Zorkoltseva et al.
Genetic correlation is a key characteristic of the global genetic similarity of human traits. Its primary underlying mechanism is pleiotropy, which operates at various biological levels. Gene-level pleiotropy is of particular interest, as g...
The role of explant type and selective agent application in the initial transformation rate of Lens culinaris Medik [0.03%]
宿主外植体类型及选择压在扁豆王冠病毒Sativa株系初始转化率中的作用研究
T V Dyubenko,K V Smirnov,V E Tvorogova
T V Dyubenko
Lens culinaris Medik. (lentil) is an agronomically important leguminous species, but its genome modification is rarely used for obtaining new varieties, probably due to a low efficiency of transformation protocols. Development of universal,...
Variability of organelle genomes in a collection of early maturing soybean varieties [0.03%]
一批早熟大豆品种细胞器基因组的变化性
V V Aleksandrovich,M G Siniauskaya,A P Shatarnov et al.
V V Aleksandrovich et al.
Variability of the genomes of cellular organelles (chloroplast and mitochondria) is an important component of the overall variability of the plant genome. A large amount of data has already been obtained on the comparative characteristics o...
Analysis of PR-1, PR-2, PR-10, chitinases and chitinase-like proteins genes expression in pea roots under the action of salicylic acid and methyl jasmonate [0.03%]
水杨酸和甲基茉莉酸处理对豌豆根系PR-1、PR-2、PR-10、几丁质酶和几丁质酶样蛋白基因表达分析
A M Egorova
A M Egorova
Stress phytohormones - salicylic and jasmonic acids - participate in the plant defense response. The increase in the content of these compounds during plant infection by pathogens leads to the activation of signaling pathways, ultimately re...
Novel regulatory SNPs that can be activated due to metformin treatment may orchestrate liver gluconeogenesis and add to the variability in AMPK-dependent mechanisms of metformin response [0.03%]
新颖的调节性SNP由于二甲双胍治疗被激活可能会协调肝脏糖异生并增加AMPK依赖性机制的二甲双胍应答变异性
E E Korbolina,I S Damarov,T I Merkulova
E E Korbolina
Metformin is a first-line therapy for type 2 diabetes, yet individual response varies significantly, with over 30 % of patients failing to achieve optimal glycemic control. The specific regulatory mechanisms of this phenomenon remain poorly...
Concept of natural genome reconstruction. Part 4. Integration of extracellular double-stranded DNA fragments into the genome of hematopoietic stem cells and the formation of extrachromosomal intermediates [0.03%]
天然基因组重建的概念。第4部分：将细胞外双链DNA片段整合到造血干细胞基因组中及其形成染色体外中间体的概念
S G Oshikhmina,V S Ruzanova,G S Ritter et al.
S G Oshikhmina et al.
To assess the possibility of integrating extracellular double-stranded DNA fragments into the recipient genome of hematopoietic stem cells, a complex substrate was constructed consisting of the entire M13F-AluI-M13R fragment and its two res...
Molecular genetic variability in coenopopulations of Caragana jubata (Pall.) Poir. (Fabaceae) in the mountains of Central Asia and Southern Siberia revealed using ISSR-markers [0.03%]
基于ISSR标记揭示中亚和西伯利亚南部山地锦鸡儿复合种群的分子遗传变异
D A Krivenko,O A Chernysheva,I N Kuban et al.
D A Krivenko et al.
The genetic structure was studied using five ISSR markers in 44 individuals of samples obtained from eight coenopopulations (CPs) of Caragana jubata (Pall.) Poir. in the mountainous conditions of Central Asia - in the Western Pamirs and Inn...
Naïve human iPSCs obtained by culturing the ICGi022-A cell line with primed pluripotency in HENSM medium efficiently differentiate into endothelial derivatives [0.03%]
在HENSM培养基中将ICGi022-A细胞系与预分化多能性共培养获得的人naïve iPSCs有效向内皮衍生物分化
M A Arssan,A I Shevchenko,S M Zakian et al.
M A Arssan et al.
Naïve human pluripotent stem cells (PSCs) are a promising new tool in biomedical research. They provide access to the early embryonic development programmes and offer breakthrough solutions in regenerative medicine. However, the current in...