New knock-in mouse lines Dmp1em1(CreERT2) and Dmp1em2(ZsGreen) enable precise osteocyte-specific targeting and visualization [0.03%]
新型Dmp1em1(CreERT2)和Dmp1em2(ZsGreen)基因敲入小鼠品系实现精确定点成骨细胞特异性靶向与示踪
Yizhong Jenny Hu,Yvonne Qianqin Guo,Ting Hsuan Wang et al.
Yizhong Jenny Hu et al.
Bone in adult mammals plays critical structural and endocrine functions, both largely rely on osteocytes-the most abundant bone cells and principal source of bone-derived hormones, such as fibroblast growth factor 23 and sclerostin. The wid...
Histomorphometric bone analysis in premenopausal women with longstanding rheumatoid arthritis and osteoporosis [0.03%]
长期患类风湿性关节炎和骨质疏松的绝经前女性的骨 histomorphometry 分析
Mariana O Perez,Lucas P Sales,Vanda Jorgetti et al.
Mariana O Perez et al.
Data on bone microarchitecture in premenopausal women with RA are scarce and have not been evaluated using histomorphometry. We assessed bone fragility in premenopausal RA women through static and dynamic histomorphometric parameters, compa...
Osteocytes regulate osteoprotegerin expression via the p38-MAPK-CREB pathway in rheumatoid arthritis [0.03%]
骨细胞通过p38-MAPK-CREB信号通路调节类风湿关节炎中的osteoprotegerin表达
Keitaro Yasumoto,Toshifumi Fujiwara,Toshiaki Sugita et al.
Keitaro Yasumoto et al.
Rheumatoid arthritis (RA) is accompanied by systemic and local bone loss, yet the regulation of osteoclast-modulating factors within human osteocytes under inflammatory conditions remains incompletely understood. As an exploratory study, we...
Bone material strength index: differences by race/ethnicity in Caribbean Hispanic, non-Hispanic White, and non-Hispanic Black older US adults [0.03%]
骨材料强度指数：美国加勒比海地区西班牙裔、非西班牙裔白人和非西班牙裔黑人老年人的种族/族裔差异
Luis Ortiz Vasquez,Carmen Germosen,Isabella Rosillo et al.
Luis Ortiz Vasquez et al.
Racial differences in fracture risk are not fully explained by differences in areal BMD (aBMD) as measured by DXA. Other aspects of bone quality, such as bone material properties, are not captured by DXA, but may contribute to fracture risk...
β2-adrenoceptor signaling in chondrocytes regulates long bone growth, bone homeostasis, and fracture healing in mice [0.03%]
小鼠软骨细胞中的β2肾上腺素能受体信号传导调节长骨生长、骨稳态和骨折愈合
Melanie Rebecca Kuhn,Melanie Haffner-Luntzer,Sandra Dieterich et al.
Melanie Rebecca Kuhn et al.
Catecholamines are known to interact with bone and cartilage cells via binding to adrenergic receptors. Among these, the β2-adrenoceptor (β2-AR) plays a key role in mediating the effects of catecholamines on bone. Mice lacking the β2-AR ...
IGF-1 from bone marrow Adipoq-lineage cells stimulates endocortical bone formation in mature female mice [0.03%]
骨髓脂肪细胞谱系细胞源的IGF-1刺激成熟雌性小鼠内层骨形成
Joshua C Bertels,Jasmin Koehnken Sawall,Brian Dulmovits et al.
Joshua C Bertels et al.
Insulin-like growth factor 1 (IGF-1) is an anabolic signal promoting growth, differentiation and function of both embryonic and postnatal tissues. Both endocrine and paracrine functions of IGF-1 have been documented to regulate bone growth ...
Association between drinking water hardness and incidence of hospitalization for childhood fracture: an ecological study of England [0.03%]
关于饮用水硬度与儿童骨折住院率关系的生态学研究英格兰地区的研究报告
Clementine Kerwin,Emma M Clark,Andrew Judge et al.
Clementine Kerwin et al.
Bone fracture during childhood is a common injury, with rates in early adolescence equivalent to that of older age. Nutrition is profoundly important for healthy skeletal development, although data are scarce on the extent to which bone-for...
Marked regression of calcinosis with canakinumab in hyperphosphatemic familial tumoral calcinosis [0.03%]
卡纳单抗治疗高磷血症家族性肿瘤钙化病的疗效明显
Astrid Dauchez,Julia Herrou,Fadila Mihoubi-Bouvier et al.
Astrid Dauchez et al.
Hyperphosphatemic familial tumoral calcinosis (HFTC) is a rare autosomal recessive disease caused by pathogenic variants in genes involved in phosphate homeostasis, and characterized by elevated serum phosphate levels and the development of...
Case Reports
JBMR plus. 2026 Feb 19;10(4):ziag026. DOI:10.1093/jbmrpl/ziag026 2026
Upper arm administration is associated with higher injection site pain with romosozumab: a randomized controlled trial and a self-controlled study [0.03%]
上臂给药与romosozumab注射部位疼痛加剧有关：一项随机对照试验和自身对照研究的结果
Soji Tani,Tomoyuki Asada,Hiro Hasegawa et al.
Soji Tani et al.
These 2 prospective studies investigated whether the injection site influences pain and local reactions with romosozumab treatment for osteoporosis. In Study 1, 169 patients were randomly assigned to receive monthly romosozumab 210 mg (2 vi...
Clinical Trial
JBMR plus. 2026 Feb 14;10(4):ziag022. DOI:10.1093/jbmrpl/ziag022 2026
Changes in bone characteristics precede serum mineral deterioration in a mouse model of early stage chronic kidney disease [0.03%]
慢性肾脏病早期阶段小鼠模型中骨特征的改变先于血清矿质的恶化
Lieve Verlinden,Ingrid Stockmans,Karen Moermans et al.
Lieve Verlinden et al.
Calcium metabolism is tightly regulated and involves hormonal communication between the intestine, kidney, and bone. Renal failure leads to impaired calcium homeostasis, but how each of the calcium-handling tissues adapts during the initial...