Histological and molecular characterization of bone integrity in osteogenesis imperfecta: a case series across genetic subtypes [0.03%]
遗传亚型的骨脆症骨完整性组织学和分子特征研究：系列病例分析
Zhiming Wu,Suzanne den Haan,Helen E King et al.
Zhiming Wu et al.
Osteogenesis imperfecta (OI) is a genetically heterogeneous skeletal disorder characterized by bone fragility and variable clinical severity. However, how molecular defects translate into alterations of bone microstructure and composition a...
Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL [0.03%]
维生素K和维生素D对骨密度的相互影响：来自Vitamin D和Omega-3_TRIAL研究的结果
Sharon H Chou,Sarah L Booth,Nancy R Cook et al.
Sharon H Chou et al.
Sufficient intake of both vitamin D and K may be necessary for bone health. Although the synthesis of osteocalcin (OC) is stimulated by vitamin D, OC needs to be carboxylated, or activated, by vitamin K to deposit calcium into bone. In the ...
Bone anabolic effects of tibial loading in combination with dual sclerostin and Dkk1 antibodies in aged mice [0.03%]
联合使用Sclerostin和Dkk1抗体促进胫骨力学刺激的骨形成效应——在老年小鼠中的研究
Lisa Y Lawson,Christopher J Chermside-Scabbo,Michael D Brodt et al.
Lisa Y Lawson et al.
Aging is associated with decreased bone formation and bone mass and increased fracture risk. Wnt pathway activation by mechanical loading is a potent strategy to improve bone mass; however, load-induced bone formation is diminished with agi...
Intensive, interdisciplinary pain treatment in fibrous dysplasia/McCune-Albright syndrome [0.03%]
纤维性骨营养不良/麦库恩-奥尔布赖特综合征的强化、跨学科疼痛治疗
Camryn Berry,Edin Randall,Julie Shulman et al.
Camryn Berry et al.
Pain in fibrous dysplasia/McCune-Albright syndrome (FD/MAS) remains inadequately treated. The pilot study was aimed to determine the feasibility (ie, completion, retention, and acceptability) and to explore the effectiveness of an intensive...
Effectiveness, safety, and pharmacokinetics of burosumab in Chinese children with X-linked hypophosphatemia: an open-label, single-arm phase 4 study [0.03%]
布罗舒马斯特用于中国X连锁低磷血症儿童患者的有效性、安全性和药代动力学：一项开放标签、单臂、Ⅳ期研究
Wei Wu,Yan Jiang,Zhenlin Zhang et al.
Wei Wu et al.
Burosumab has shown benefits in treating X-linked hypophosphatemia (XLH), a rare genetic bone disorder that causes rickets among pediatric patients. However, data in Chinese children with XLH are lacking. Therefore, we evaluated the effecti...
Bioelectrical phase angle predicts sarcopenia in older adults with type 2 diabetes mellitus [0.03%]
生物电相位角可预测2型糖尿病老年人的肌少症
Methavee Poochanasri,Kasidid Lawongsa,Thanapat Limpaarayakul et al.
Methavee Poochanasri et al.
Sarcopenia is common among older adults with type 2 diabetes mellitus (T2DM) and is associated with increased risks of functional decline and adverse health outcomes. Phase angle (PhA), derived from bioelectrical impedance analysis, has eme...
Development of an automated landmarking tool for the femur in dual-energy X-ray absorptiometry scans using contour-based image analysis [0.03%]
基于轮廓的图像分析在双能X线吸收法扫描中自动构建股骨影像特征点的工具研发
Edward M Chu,Jonathan D Adachi,Cheryl E Quenneville
Edward M Chu
Osteoporosis is a skeletal disease that significantly increases fracture risk and imposes a growing public health and economic burden. Notably, hip fractures are associated with high mortality, long-term disability, and loss of independence...
Molecular mechanisms of ANKH function and regulation in skeletal mineralization [0.03%]
ANKH分子功能及调控在骨骼矿化中的机制研究
Nuwanthika Wathuliyadde,Katherine E Willmore,Gregory M Kelly
Nuwanthika Wathuliyadde
Progressive ankylosis homolog (ANKH) is a transmembrane protein essential for regulating bone mineralization through the export of nucleoside triphosphates, primarily adenosine triphosphate (ATP), and citrate into the extracellular matrix. ...
Hypertension worsens bone loss and weakens bone in aged ovariectomized mice [0.03%]
高血压加重骨丢失并使骨质脆弱化——卵巢切除绝经动物模型研究
Elizabeth M Hennen,Sasidhar Uppuganti,Santosh Thapa et al.
Elizabeth M Hennen et al.
The occurrence of both hypertension and osteoporosis increases after menopause, and fracture risk is higher in adults with hypertension than in adults without this chronic disease. We hypothesized that ovariectomy (OVX)-induced estrogen-def...
Influencing factors and early warning indicators for nonvertebral fractures in patients with Duchenne muscular dystrophy [0.03%]
杜氏肌营养不良患者非椎体骨折的影响因素及预警指标分析
Changping Yan,Sen Kou,Shu Zhang et al.
Changping Yan et al.
Nonvertebral fractures (NVFs) in patients with Duchenne muscular dystrophy (DMD) are often associated with an unfavorable prognosis. However, the influencing factors and early warning indicators for NVFs remain unclear. To address this know...