Follistatin-like protein 1 (FSTL1) modulates bone remodeling and attenuates bone loss in a mouse model of postmenopausal osteoporosis [0.03%]
骨形态发生蛋白受体激活剂FSTL1通过调节成骨和破骨细胞功能减轻绝经后骨丢失
Hao Yuan,Bao-Rui Chen,Fu-Xing Han et al.
Hao Yuan et al.
This study systematically delineates the expression dynamics of follistatin-like protein 1 (FSTL1) in postmenopausal osteoporosis (PMOP) and elucidates its role in skeletal homeostasis. Integrated analyses of clinical serum samples and the ...
Impaired bone matrix maturation and mineralization are prevalent in adolescent end-stage kidney disease [0.03%]
青少年终末期肾病中骨基质成熟和矿化异常的普遍性
Nadja Fratzl-Zelman,Renata C Pereira,Stéphane Blouin et al.
Nadja Fratzl-Zelman et al.
Children and adolescents with end-stage kidney disease (ESKD) have a high prevalence of bone deformities and fractures, even when bone histomorphometric measures of bone formation, mineralization, and volume are within normal range. We post...
The therapeutic window: timing dentoalveolar surgery to minimize MRONJ risk in denosumab-treated osteoporotic patients [0.03%]
治疗时间窗：最小化地诺单抗治疗骨质疏松患者牙槽手术中发生颌骨坏死的风险
Daya Masri,Eli Rosenfeld,Shaked Adut et al.
Daya Masri et al.
Osteoporosis patients treated with denosumab (Dmab) remain at risk for medication-related osteonecrosis of the jaw (MRONJ), particularly after dentoalveolar surgery. Optimizing surgical timing may reduce this risk while avoiding complicatio...
Establishment and characterization of a human pre-osteocyte cell line: hOsteo4-E9 [0.03%]
人成骨细胞系hOsteo4-E9的建立及鉴定
Lei Qin,Zecai Chen,Zhen Xu et al.
Lei Qin et al.
Osteocytes, as the most abundant and long-lived cell type in bone tissue, have garnered significant attention due to their critical roles in bone remodeling, bone mechanobiology, bone-related diseases, and systemic homeostasis. While severa...
Thra knockout protects male mice from hyperthyroidism-driven cortical bone loss by mitigating bone resorption [0.03%]
甲状腺功能亢进引起的破骨细胞活化导致小鼠皮质骨丢失,Thra敲除通过降低骨吸收缓解骨丢失
Franziska Brinkmann,Eleonore Kreß,Christiane Schirm et al.
Franziska Brinkmann et al.
Secondary osteoporosis is a major global health problem and can be caused by endocrine diseases, including hyperthyroidism. Of note, hyperthyroid mice exhibit both trabecular and cortical bone loss, accompanied by reduced bone strength, as ...
Association between chronic inflammation and poorer long-term functional recovery post-hip fracture in and between men and women [0.03%]
慢性炎症与髋部骨折后男性和女性长期功能恢复不良之间的关联研究
Marty Eastlack,Zhaoyong Feng,Laurence S Magder et al.
Marty Eastlack et al.
Mechanisms underlying functional recovery after hip fracture have not been widely studied in either sex, but particularly not in men. Cytokines, or biomarkers of inflammation in the blood, are associated with declines in function post hip f...
Impaired bone matrix turnover with selective small bone fragility in a child with TENT5A-associated osteogenesis imperfecta [0.03%]
TENT5A相关性成骨不全症儿童患者的骨基质周转障碍及小梁骨脆弱性受损
Alex Guo,Cara Tillotson,Cecilia Sena et al.
Alex Guo et al.
Osteogenesis imperfecta (OI) encompasses a genetically diverse spectrum of skeletal dysplasias, commonly linked to pathogenic variants in COL1A1 and COL1A2. Emerging data identify terminal nucleotidyltransferase 5A (TENT5A)-a noncanonical c...
The orally available SIK2/SIK3 inhibitor SK-124 increases bone mass in hypogonadal male mice [0.03%]
口服可用的SIK2/SIK3抑制剂SK-124可增加低性腺功能男性小鼠的骨量
Roy B Choi,Sung-Hee Yoon,Parthena E Kotsalidis et al.
Roy B Choi et al.
At present, there are no FDA-approved orally-available bone anabolic agents to treat osteoporosis. PTH stimulates bone formation through an intracellular signaling cascade that involves the inhibition of salt-inducible kinase (SIK) isoforms...
Open and reproducible research in musculoskeletal imaging: why it matters and how to implement it with the guidelines of the Open and Reproducible Musculoskeletal Imaging Research (ORMIR) community [0.03%]
开放且可重复的肌肉骨骼影像学研究：为什么重要及其实施方法——依据“开放和可重复的肌肉骨骼影像学研究（ORMIR）”社区准则
Serena Bonaretti,Mojtaba Barzegari,Melissa Bevers et al.
Serena Bonaretti et al.
The Open and Reproducible Musculoskeletal Imaging Research community is a scientific community dedicated to promoting openness and reproducibility in musculoskeletal imaging, image processing, and computational modeling. In this perspective...
Rethinking race-based interpretation in pediatric densitometry: a scoping review [0.03%]
基于种族的解释在儿科密度测定中的再思考：系统评价
Amira Ramadan,Zakora Moore,Usman A Ahmed et al.
Amira Ramadan et al.
As pediatric populations in the United States (US) become increasingly diverse, current practices for interpreting bone density using DXA in children warrant reevaluation. The International Society for Clinical Densitometry currently recomm...