The orally available SIK2/SIK3 inhibitor SK-124 increases bone mass in hypogonadal male mice
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At present, there are no FDA-approved orally-available bone anabolic agents to treat osteoporosis. PTH stimulates bone formation through an intracellular signaling cascade that involves the inhibition of salt-inducible kinase (SIK) isoforms 2 and 3. Therefore,... ...
