In silico prioritization and cheminformatics identify structurally diverse small-molecule inhibitors of Lassa virus glycoprotein-mediated membrane fusion [0.03%]
基于计算的优先排序和化学信息学鉴定结构多样的拉沙病毒糖蛋白介导膜融合的小分子抑制剂
Brianna Close,Bruno La Rosa,Cameron Ong et al.
Brianna Close et al.
Lassa virus (LASV) is a hemorrhagic fever arenavirus of significant public health concern, infecting millions of people per year in Africa. Here, we developed a computational strategy to identify specific inhibitors of LASV glycoprotein-med...
Identification of novel diagnostic biomarkers and host-directed drug screening for Mycobacterium avium infection: A multi-omics and artificial intelligence study [0.03%]
利用多组学和人工智能技术筛选分枝杆菌感染的诊断标志物及宿主靶向药物研究
Zihan Cai,Chunxiao Huang,Xiaomei Yi et al.
Zihan Cai et al.
Objective: The rising incidence of Mycobacterium avium (MAV) infection poses significant challenges due to diagnostic delays and refractory treatment. Understanding host immune remodeling-particularly myeloid heterogeneit...
Development of a Rapid and Sensitive EnLIGHT OMEGA assay for extracellular AGR2 Detection in Biological Fluids [0.03%]
一种用于快速灵敏检测生物液体中AGR2的EnLIGHT OMEGA检测试剂盒的开发
Lena Gosset,Guillaume Babin,Philippe Roby et al.
Lena Gosset et al.
Anterior gradient 2 (AGR2) is an endoplasmic reticulum -resident protein belonging to the disulfide isomerase family. AGR2 contributes to protein quality control and unfolded protein response (UPR). In addition to its canonical intracellula...
Development of a High-Throughput TR-FRET Assay for Identification of Small Molecule Inhibitors of the LILRB4 (ILT3)-SCG2 Immune Checkpoint Interaction [0.03%]
用于鉴定LILRB4（ILT3）-SCG2免疫检查点互作的小分子抑制剂的高通量TR-FRET测定法的研究开发
Somaya A Abdel-Rahman,Moustafa T Gabr
Somaya A Abdel-Rahman
Leukocyte immunoglobulin-like receptor B4 (LILRB4, ILT3) is an inhibitory immune checkpoint expressed on myeloid cells, where it contributes to immunosuppression within the tumor microenvironment. Secretogranin 2 (SCG2) has recently been id...
Thermodynamic Profiling and Fragment Screening of GPCRs Using Grating-Coupled Interferometry [0.03%]
用于G蛋白偶联受体的光栅耦合干涉测量法热力学分析及片段筛选技术
Alicia Churchill-Angus,Sara Crespillo-Torreno,Erika Griss et al.
Alicia Churchill-Angus et al.
G protein-coupled receptors (GPCRs) represent one of the most important target classes in drug discovery, yet many remain pharmacologically underexplored due to limited biological knowledge and technical challenges associated with their cha...
Identification of AMPD2 Allosteric Inhibitors with Novel Mechanism of Action by Fragment Merging Approach [0.03%]
基于片段合并方法鉴定AMPD2 allosteric抑制剂及其新颖的作用机制
Kenji Yamanaka,Toru Uhara,Akihiro Nomura et al.
Kenji Yamanaka et al.
Adenosine monophosphate deaminase 2 (AMPD2) catalyzes the conversion of adenosine monophosphate (AMP) to inosine monophosphate and is believed to play a significant role in nucleotide metabolism, energy homeostasis, and immune oncology. Thr...
A High Throughput Assay to Identify Modulators of Death Receptor 3 (DR3) [0.03%]
一种高通量检测调节死亡受体3(DR3)的药物的筛选模型
Emery Smith,Joshua K Parker,Izan Gonzalez Fayos et al.
Emery Smith et al.
Association of the TNF-like cytokine 1A (TL1A) with Death Receptor 3 (DR3) triggers a signaling cascade in T cells that results in the increased AP-1- and NF-κB-mediated expression of inflammation-promoting gene products. Dysregulation of ...
Repurposing drug screen for the identification of helicase inhibitors from viruses of pandemic concern [0.03%]
药物再利用筛选鉴定来自大流行病毒解旋酶抑制剂的方法
Nicole L Inniss,Margarita Rzhetskaya,Ryan P Kich et al.
Nicole L Inniss et al.
Several families of viruses encode helicase enzymes with essential roles in viral genome replication and transcription, including several RNA virus families of pandemic concern, such as coronaviruses and flaviviruses. Viral helicases are wi...
Cleaving through complexity: Pan-serotype fluorimetric assays for the dengue virus proteases [0.03%]
透过复杂度：登革热病毒蛋白酶的全血清型荧光测定法
Miguel M Macedo,Johannes Lang,Katharina Eckstein et al.
Miguel M Macedo et al.
Dengue virus (DENV) is a health threat with global impact. The viral NS2B/NS3 protease is responsible for viral polyprotein processing at a number of cleavage sites. This cleavage is indispensable for establishing productive infection, high...
The emerging synergy of experimental and computational approaches for therapeutic modulation of biomolecular condensates [0.03%]
实验和计算方法在生物分子凝聚体治疗调控中的协同作用力不容小觑
Priyesh Mohanty,Shiv Rekhi,Aahil Khambhawala et al.
Priyesh Mohanty et al.
Biomolecular condensates (BCs) are membraneless organelles which play roles in key biological functions such as RNA metabolism, signal transduction and DNA repair, reflecting their importance in cellular organization and function. The dysre...