Yuka Otsuka,Justin Shumate,Teresa Findley Rye et al.
Yuka Otsuka et al.
Research engaged with AI has dramatically increased due to a huge improvement of technologies in terms of cost and time-effectiveness as well as decreasing use of animals. High throughput screening (HTS) is a frequently used method in drug ...
A high throughput screening platform for label-free identification and characterization of GPCR ligands using impedance-based real-time cellular analysis [0.03%]
一种高通量筛选平台用于使用阻抗实时细胞分析法无标记鉴定和表征GPCR配体
Frederik Bangnowski,Robert Ries,Michael Karnath et al.
Frederik Bangnowski et al.
Real-time cell analysis (RTCA) is a biosensor technology that enables kinetic monitoring of cellular activities via electrical impedance. Among its multiple applications, this label-free method offers a holistic approach to monitoring the a...
Three high throughput compatible cell-based assays for identifying small molecule JAG1 upregulators for Alagille syndrome [0.03%]
三种高效的细胞基于高通量筛选小分子诱导JAG1表达的化合物治疗Alagille综合征
Molly R Kulikauskas,Xiuli Huang,Ivan Pavlinov et al.
Molly R Kulikauskas et al.
Haploinsufficiency disorders arise when loss of function mutations in one allele of a gene reduce gene dosage below the level required for normal physiology. Pharmacologic upregulation of the remaining functional allele represents a promisi...
From complexity to clarity: building dashboards for hit selection in high throughput screens [0.03%]
从复杂性到清晰度：在高通量筛选中构建用于选择命中的仪表板
Karla J Cowley,Hermione Allen,Kaylene J Simpson
Karla J Cowley
High throughput screening produces large, complex datasets that are difficult to interrogate without programming expertise, making hit selection time-consuming and inflexible. While instrument software and commercial tools offer partial sol...
SLAS discovery - special issue - biomolecular condensate drug discovery [0.03%]
SLAS发现-生物分子凝聚体药物发现专题期刊
Charles P Hart
Charles P Hart
A Hybrid Experimental and in silico Platform for ITPK1 Chemical Probe Discovery [0.03%]
用于ITPK1化学探针发现的混合实验和计算平台
Adam Yasgar,Sankalp Jain,Huanchen Wang et al.
Adam Yasgar et al.
Inositol-tetrakisphosphate 1-kinase (ITPK1) is a pivotal enzyme in the inositol phosphate signaling pathway that functions to maintain the balance of inositol phosphate (IP) species. Dysregulation of this pathway has been linked to human di...
Tumor-versus-nonmalignant quantitative drug sensitivity profiling identifies capivasertib as a selective therapeutic candidate for nasopharyngeal carcinoma [0.03%]
定量药物敏感性谱分析识别出Capivasertib可作为鼻咽癌的候选靶向治疗药物
Haiying Yu,Ke Du,Chuanhua Cao et al.
Haiying Yu et al.
Nasopharyngeal carcinoma (NPC) remains a therapeutic challenge, particularly in the recurrent or treatment-refractory setting, underscoring the need for tumor-selective therapeutic strategies. In this study, we applied a tumor-normal-paired...
ADCs for Colorectal Carcinoma: Decoding Clinical Evidence for Molecular Design Innovation [0.03%]
抗体偶联物在结直肠癌中的应用：分子设计创新的临床证据解析
Xiangxin Wu,Fenqi Du,Zhenhua Liu et al.
Xiangxin Wu et al.
Antibody-drug conjugate (ADC) is a novel type of targeted systemic therapy that is changing the current landscape of tumor treatment. By integrating the specificity of antibodies with the cytotoxic effects of their payloads, ADCs facilitate...
CellVision: A Deep Learning based Image Analysis Platform to Accelerate Immuno-Plaque Assay Data Processing for Dengue Vaccine Development [0.03%]
基于深度学习的细胞图像分析平台加速登革热疫苗研发中的免疫斑 assays 数据处理
Yi Wang,Michelle N Ngo,Shubing Wang et al.
Yi Wang et al.
Accurately detecting patterns of interest across a large number of images presents a significant challenge in data analysis for high-throughput analytical assays. In many cases, manual image review to some degree is necessary, deviating fro...
Adam Zweifach
Adam Zweifach
Some experiments generate data consisting of counts of cells in two states, such as alive or dead, CD3+ or CD3-, etc. These are often converted to percentages and analyzed with parametric statistical tests intended for means like t tests, w...