A High Throughput Assay to Identify Modulators of Death Receptor 3 (DR3)
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Association of the TNF-like cytokine 1A (TL1A) with Death Receptor 3 (DR3) triggers a signaling cascade in T cells that results in the increased AP-1- and NF-κB-mediated expression of inflammation-promoting gene products. Dysregulation of TL1A/DR3 signaling i... ...
