Germinal center-mediated broadening of B cell responses to SARS-CoV-2 booster immunization [0.03%]
生发中心介导的针对SARS-CoV-2加强免疫的B细胞反应扩大现象
Sameer Kumar Malladi,Deepika Jaiswal,Baoling Ying et al.
Sameer Kumar Malladi et al.
Germinal centers (GCs) are key sites for antibody diversification and affinity maturation. SARS-CoV-2 messenger RNA (mRNA) vaccines elicit robust GC B cell responses in humans, but how these responses influence the breadth of immunity again...
Taking aim at autoimmunity-Antigen-Fc constructs for mucosal pemphigus hit the mark [0.03%]
瞄准自身免疫性黏膜天疱疮的抗原-Fc构建体疗法应运而生
Francesca Beretta,Valentina Damato
Francesca Beretta
A desmoglein-3 antigen-Fc fusion construct shows promise as a therapeutic in a model of pemphigus vulgaris.
Lukas Bunse,Theresa Bunse,Michael Kilian et al.
Lukas Bunse et al.
Brain tumors represent a unique challenge for cancer immunotherapies because of their location in an immune privileged site. However, the brain tumor immune microenvironment is dictated more by tumor type than the location within the brain ...
The power of the few: RORγt+ dendritic cells promote food-specific peripheral regulatory T cells [0.03%]
少数派的力量：RORγt+树突状细胞促进食物特异性外周调节性T细胞
Elise G Liu,Adam Williams
Elise G Liu
Food antigen-specific peripheral regulatory T cell induction in the gut is driven by RORγt+ dendritic cells.
Vaccination-induced T cell responses maintain polyclonality with high antigen receptor avidity [0.03%]
疫苗诱导的T细胞反应保持了具有高抗原受体亲和力的多克隆性
Katharina Kocher,Felix Drost,Abel Mekonnen Tesfaye et al.
Katharina Kocher et al.
Clonal expansion is a hallmark of adaptive immunity and has been challenging to investigate in humans in a standardized manner compared with animal models. We studied a cohort of 29 healthy individuals who received three mRNA vaccinations a...
Group 2 innate lymphoid cells regulate nociceptive and gait functions of the peripheral nervous system [0.03%]
组2固有淋巴细胞调节外周神经系统的痛觉和步态功能
Divija Deshpande,Laura Velleman,Janna Schmitz et al.
Divija Deshpande et al.
The peripheral nervous system (PNS) is involved in nociception and gait. The contribution of PNS-resident immune cells to these functions is not fully understood. We identified group 2 innate lymphoid cells (ILC2s) as a distinct immune cell...
Design of a potent interleukin-21 mimic for cancer immunotherapy [0.03%]
一种用于癌症免疫治疗的高效白细胞介素-21模拟物的设计
Jung-Ho Chun,Birkley S Lim,Suyasha Roy et al.
Jung-Ho Chun et al.
Long-standing goals of cancer immunotherapy are to activate cytotoxic antitumor T cells across a range of affinities for tumor antigens while suppressing regulatory T cells. Computational protein design has enabled the precise tailoring of ...
Zhenghai Tang,André Veillette
Zhenghai Tang
Monoclonal antibodies and other agents that inactivate immune checkpoints like PD-1 and CTLA-4 have been effective against only certain types of cancer and have had highly variable efficacy in patients. These limitations have hastened inves...
Nuclear polarization to the immune synapse facilitates an early transcriptional burst [0.03%]
核极化到免疫突触促进了早期转录爆发
Yukako Asano,Claire Y Ma,Martin M Limback-Stokin et al.
Yukako Asano et al.
Target cell recognition by cytotoxic T lymphocytes (CTLs) triggers rapid delivery of cytolytic granules to the immune synapse directed by the centrosome. Recent studies have also identified a rapid burst of T cell receptor (TCR)-activated t...
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins [0.03%]
针对胆碱酶样蛋白可预防或逆转小鼠由过敏原引起的气道基质重塑
James E Parkinson,Hannah E Tompkins,Amlan Chakraborty et al.
James E Parkinson et al.
Chitinase-like proteins (CLPs) are established biomarkers of inflammation and airway remodeling in asthma, yet their direct contribution toward disease pathogenesis is unknown. In a mouse model of type 2/type 17 airway inflammation induced ...