Mycobacterial α-glucans hijack dectin-1 to facilitate intracellular bacterial survival [0.03%]
分枝杆菌α-葡聚糖劫持dectin-1以促进细菌胞内存活
Shota Torigoe,Sumayah Salie,Roanne Keeton et al.
Shota Torigoe et al.
Mycobacteria have a cell envelope that can act as a shield against host defense. This study shows that mycobacteria survive in host macrophages by targeting the innate host receptor dectin-1 through a noncanonical ligand. Compared with wild...
Segmented filamentous bacteria reprogramming of alveolar macrophages limits postinfluenza bacterial pneumonia [0.03%]
分段丝状细菌介导的肺泡巨噬细胞重编程限制了流感后继发性细菌肺炎的发展
Vu L Ngo,Carolin M Lieber,Hirohito Abo et al.
Vu L Ngo et al.
Respiratory viral infection induces depletion and dysfunction of alveolar macrophages (AMs), resulting in high-susceptibility to life-threatening bacterial pneumonia. Colonization of the intestine by segmented filamentous bacteria (SFB) rep...
DNA-damaging chemotherapy reshapes cardiac-resident macrophage composition and function [0.03%]
细胞毒性化疗重塑心脏巨噬细胞组成和功能
Ruijun He,Farid F Kadyrov,Andrew L Koenig et al.
Ruijun He et al.
Heart failure and ischemic heart disease represent prevalent causes of death among cancer survivors. Despite extensive use of conventional chemotherapies, a limited understanding of how these agents affect the cardiac immune landscape exist...
Pathogenic IgE-fated memory B cell responses retain functional plasticity [0.03%]
致病性IgE命运决定的记忆B细胞反应保持功能可塑性
Kelly Bruton,Allyssa Phelps,Atai Ariaz et al.
Kelly Bruton et al.
Long-lived immunoglobulin E (IgE) responses against innocuous environmental and dietary antigens (Ags) are maintained by an IgG1-dominant memory B cell (MBC) compartment primed for interleukin-4 (IL-4) responsiveness. The plasticity of the ...
Divergent immune responses to commensal bacteria bearing distinct motility signatures [0.03%]
具有不同运动特征的共生细菌引发不同的免疫反应
Lennard W Duck,Melissa S Jennings,Jung-Shan Hsu et al.
Lennard W Duck et al.
Adaptive immune responses to commensal flagellins are hallmarks of Crohn's disease (CD), but it is unclear whether flagellins themselves promote inflammation or whether flagellated commensals can also be colitogenic. Here, we show that the ...
Siglec-F+ neutrophils promote the resolution of acute lung injury through ALOX15 induction [0.03%]
Siglec-F+中性粒细胞通过诱导ALOX15促进急性肺损伤的消退
Luciana P Tavares,Thayse R Brüggemann,R Elaine Cagnina et al.
Luciana P Tavares et al.
Neutrophils have vital proinflammatory protective functions, but gene expression changes in neutrophils found in inflamed tissues suggest additional proresolving effects. We identified a neutrophil subset with a distinct phenotype and funct...
Human OCEL1 senses bacterial infection to unlock inflammatory responses [0.03%]
人类OCLE1感知细菌感染以释放炎症反应
Zhi Li,Jing Wang,Juan Du et al.
Zhi Li et al.
Processes that control tissue inflammation are essential to restore homeostasis after infection. The transcription factor NF-κB plays a central role in coordinating inflammation, but the mechanisms that regulate NF-κB signaling are not fu...
CD27 agonism enhances long-lived CD4 T cell vaccine responses critical for antitumor immunity [0.03%]
CD27活化增强关键的抗肿瘤免疫长期存在的CD4+T细胞疫苗反应
Bin-Jin Hwang,Erika J Crosby,David T Severson et al.
Bin-Jin Hwang et al.
Tumor antigen vaccination represents an appealing approach for cancer but has failed to materialize as oncologic standard of care. To understand long-term vaccine efficacy, we conducted a retrospective analysis of patients with human epider...
Heterogeneity of the intestinal mononuclear phagocyte compartment in health and inflammatory bowel disease [0.03%]
肠道单核吞噬细胞区隔在健康和炎症性肠病中的异质性
Thomas M Fenton,Line Wulff,Venla Väänänen et al.
Thomas M Fenton et al.
Understanding of mononuclear phagocyte (MNP) diversity in the human intestine and the alterations this compartment undergoes in inflammation remains incomplete. Here, we used single-cell RNA sequencing, cellular indexing of trancriptomes an...