Seth Thomas Scanlon
Seth Thomas Scanlon
Science Immunology celebrates its first 10 years and looks ahead.
Erratum for the Research Article "Claudins interact with LILRB immune inhibitory receptors to promote myeloid immunosuppression in cancer" [0.03%]
关于研究论文“ Claudins与LILRB免疫抑制受体相互作用，促进癌症中的髓系细胞免疫抑制”的勘误修正通知
Published Erratum
Science immunology. 2026 Jun 26;11(120):eaej3848. DOI:10.1126/sciimmunol.aej3848 2026
Langerhans cell control of early-life dermal lymphatic development shapes adult immunity [0.03%]
朗格汉斯细胞控制早期生命表皮淋巴管发育塑造成人免疫环境
Ji Hyun Sim,Richard Bell,Yurii Chinenov et al.
Ji Hyun Sim et al.
The communication between skin and draining lymph nodes is crucial for immune responses to skin insults. Lymphatic vessels play key roles in this communication by transporting antigens from skin to lymph nodes, and mechanisms that compromis...
Treg cells promote immunotherapy-induced immune evasion by restraining CD4 T cell control of MHC-I-deficient metastatic pancreatic cancer [0.03%]
调节性T细胞通过限制CD4 T细胞控制MHC-I缺陷型转移性胰腺癌来促进免疫治疗诱导的免疫逃逸
Zoe C Schmiechen,Eduardo Cruz-Hinojoza,Audrey L Hilk et al.
Zoe C Schmiechen et al.
Mechanisms driving immunotherapy resistance in pancreatic cancer are poorly defined. We demonstrate that programmed death-ligand 1 immune checkpoint blockade promoted immune evasion by epigenetic Tap1 (transporter associated with antigen pr...
CXCL16-mediated recruitment of γδ T cells to the brain reduces sociability in mice [0.03%]
CXCL16介导的γδT细胞向大脑募集可减少小鼠社会性行为
Natsumi Takayama,Koyomi Shiraishi,Ako Matsui et al.
Natsumi Takayama et al.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder shaped by genetic factors such as copy number variations (CNVs) and immunological factors such as maternal infection. However, most studies on the development of genetic ASD ha...
Bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles (BEACONs) for mucosal vaccination against genital herpes [0.03%]
用于生殖器疱疹粘膜免疫的生物活性增强型佐剂趋化性寡核苷酸纳米颗粒(BEACON)
Sachin H Bhagchandani,Stephen Ehrenzeller,Ivan S Pires et al.
Sachin H Bhagchandani et al.
Genital herpes, caused by herpes simplex virus 2 (HSV-2), remains a prevalent sexually transmitted infection with no available vaccine. Effective local immunity, mediated in part by tissue-resident memory T cells (TRM cells) and luminal ant...
Bacterial infection reshapes monocyte and macrophage ontogeny at the CNS borders [0.03%]
细菌感染重塑中枢神经系统的单核细胞和巨噬细胞谱系发育
Vitka Gres,Florens Lohrmann,Vidmantė Fuchs et al.
Vitka Gres et al.
Macrophages in the meninges contribute to immune defense of the central nervous system (CNS), yet their site-specific origin and function remain poorly understood. Using an intravenous model of streptococcal meningoencephalitis in mice, we ...
The tissue-specific regulation of immunobiology by IL-17 signaling [0.03%]
白介素17信号的免疫生物学作用及组织特异性调节机制研究进展
Yang Li,Shachi P Vyas,Peter Draber et al.
Yang Li et al.
IL-17 family cytokines are central regulators of tissue immunity. Here, we review recent advances in defining the cell- and tissue-specific activities of IL-17, emphasizing the signaling pathways engaged by IL-17 receptor (IL-17R) complexes...
DDX6 induces immunosuppression in cancer by disrupting structural stability of endogenous double-stranded RNAs [0.03%]
DDX6通过破坏内源性双链RNA的结构稳定性诱导癌症免疫抑制
Larry Ng,Vincent Tano,Priyankaa Pitcheshwar et al.
Larry Ng et al.
Cellular double-stranded RNA (dsRNA) can activate immune pathways similar to viral RNA. Adenosine deaminases acting on RNA 1 (ADAR1)-mediated adenosine-to-inosine (A-to-I) RNA editing has long been believed to destabilize endogenous dsRNA, ...
Cytotoxic CD39+ tumor-associated NK cells respond to NKG2A blockade in lung cancer [0.03%]
肺癌中的细胞毒性CD39+NK细胞对NKG2A阻断的反应
Clara Serger,Lucas Rebuffet,Michael T Sandholzer et al.
Clara Serger et al.
Natural killer (NK) cell-targeting immunotherapies are emerging, yet the differentiation and functional states of tumor-infiltrating NK cells remain poorly understood. Using matched single-nucleus RNA and ATAC sequencing of samples from pat...