Misfirin' pyrin [0.03%]
误激活的Pyrin蛋白质
Fiachra Humphries
Fiachra Humphries
Three studies identify CDC42 as binding partner of the pyrin B30.2 domain, establishing a previously unrecognized mechanism regulating pyrin inflammasome activation (see related Research Articles by Aoki et al., Feng et al., and Iwata et al...
PKM2 works "off the books" to drive effector T cell function in MS [0.03%]
PKM2通过非经典方式驱动多发性硬化症效应T细胞的功能
Alexia Falle,Manu Rangachari
Alexia Falle
The noncanonical functions of PKM2 drive pathogenic T cell function in patients with MS.
A genotype-first approach reveals the molecular basis of pyrin inflammasome activation [0.03%]
基因型优先方法揭示了Pyrin炎症小体激活的分子机制
Naoya Iwata,Yoshihiko Kuchitsu,Atsushi Hijikata et al.
Naoya Iwata et al.
Mutations in the MEFV gene, which encodes pyrin, are associated with a spectrum of inflammatory conditions called pyrin-associated autoinflammatory diseases (PAADs). Of the 400 MEFV variants listed in the Infevers database, most are classif...
Mist-ical memory: The airway defenses induced by FluMist vaccination in adults [0.03%]
魔幻记忆：FluMist疫苗在成人中诱导的呼吸道防御作用
Huzaifa Zohair,Priyadharshini Devarajan
Huzaifa Zohair
Longitudinal nasopharyngeal swabs sample and reveal upper airway humoral memory generated after intranasal FluMist vaccination.
An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation [0.03%]
一个N端CDC42 T43I变异体揭示了Pyrin炎症小体的激活机制
Mariko Aoki,Alberto Iannuzzo,Philippe Mertz et al.
Mariko Aoki et al.
Heterozygous carboxyl-terminal variants in the RHO guanosine triphosphatase (GTPase) CDC42 are known to cause severe autoinflammatory syndromes. Here, we identified a heterozygous amino-terminal p.T43I (Thr43→Ile) CDC42 variant in patients...
An autoinflammatory CDC42 variant M45L demonstrates the mechanism of pyrin inflammasome activation [0.03%]
自身炎症性CDC42变异体M45L展示了Pyrin炎性小体活化的机制
Shouya Feng,Thomas Reygaerts,Klara Kong et al.
Shouya Feng et al.
CDC42 is an evolutionarily conserved guanosine triphosphatase (GTPase) regulating critical cellular and immune processes. Variants in CDC42 therefore cause a spectrum of developmental phenotypes, including hematological and immunological sy...
Dynamic expression of IL-21 in effector CD8 T cells helps control chronic infections [0.03%]
效应CD8 T细胞中白细胞介素-21的动态表达有助于控制慢性感染
Zixuan Zhao,Han Feng,Xiaohong Zhao et al.
Zixuan Zhao et al.
CD8 T cells are critical players in immune responses against pathogens. Interleukin-21 (IL-21) is predominantly produced by CD4 T cells and exerts multifaceted effects on CD8 T cell regulation and function. Using Il21-reporter and Il21-fate...
Two differentiation pathways generate large peritoneal macrophages with one replenishing mesothelial border macrophages [0.03%]
两条分化途径生成大量的腹膜巨噬细胞并有一条补充间皮边缘巨噬细胞
Jichang Han,Alexandre Gallerand,Rachel L Mintz et al.
Jichang Han et al.
Peritoneal cavity fluid and mesothelial surfaces host distinct resident macrophage populations, among which include the well-described Gata6+ large cavity macrophages (LCMs) in peritoneal fluid. Here, we reveal that LCMs arise from two sepa...
Dynamic regulation of lysine and arginine metabolism promotes immune evasion by limiting T cell function in cancer [0.03%]
动态调节组蛋白精氨酸和赖氨酸修饰限制T细胞功能促进肿瘤免疫逃逸
Weiwei Yu,Ruya Sun,Xiaoyang Lu et al.
Weiwei Yu et al.
Tumor cells promote metabolic dysregulation of immune cells by controlling the metabolic landscape of the tumor microenvironment. It is unclear whether tumors restrict specific nutrients to drive rapid growth and immune evasion in addition ...
Mark B Leick,Baihe Sun,Filippo Birocchi et al.
Mark B Leick et al.
Germline variants influence immune checkpoint inhibitor responses, but their role in engineered immune cell therapies, such as chimeric antigen receptor T cells (CAR T cells), remains unclear. We integrated whole germline sequencing from pa...