Dynamic regulation of lysine and arginine metabolism promotes immune evasion by limiting T cell function in cancer [0.03%]
动态调节组蛋白精氨酸和赖氨酸修饰限制T细胞功能促进肿瘤免疫逃逸
Weiwei Yu,Ruya Sun,Xiaoyang Lu et al.
Weiwei Yu et al.
Tumor cells promote metabolic dysregulation of immune cells by controlling the metabolic landscape of the tumor microenvironment. It is unclear whether tumors restrict specific nutrients to drive rapid growth and immune evasion in addition ...
Mark B Leick,Baihe Sun,Filippo Birocchi et al.
Mark B Leick et al.
Germline variants influence immune checkpoint inhibitor responses, but their role in engineered immune cell therapies, such as chimeric antigen receptor T cells (CAR T cells), remains unclear. We integrated whole germline sequencing from pa...
Maria Pia Holgado,Samuel Origlio,Lucas Bertoia et al.
Maria Pia Holgado et al.
B cells generate plasma cells (PCs) and memory B cells (MBCs) to combat recurrent pathogens. B cell receptor (BCR) affinity dictates fate decisions in response to model antigens, but the factors regulating B cell fate during infection remai...
Macrophage-derived oxysterols organize T helper 2 cells to suppress type 1 inflammation during pulmonary fungal infection [0.03%]
巨噬细胞衍生的氧化固醇在肺部真菌感染期间组织辅助性T2细胞以抑制I型炎症
Yufan Zheng,Hannah E Dobson,Makheni Jean Pierre et al.
Yufan Zheng et al.
Effective pulmonary immunity requires the precise spatial organization of immune cells, yet the mechanisms guiding their intratissue positioning during inflammation remain unclear. Here, we identify a cholesterol-derived chemotactic axis th...
The efficacy of immunotherapy in glioma requires distal B cell responses in tumor-draining lymph nodes [0.03%]
免疫疗法治疗胶质瘤的有效性要求肿瘤引流淋巴结中远端B细胞的反应
Yumin Kim,In Kang,Byeong Hoon Kang et al.
Yumin Kim et al.
Humoral immunity, mediated by B cells that mature in germinal centers in lymph nodes (LNs), is essential for adaptive immune responses, but its role in antitumor immunity and responses to immunotherapy remain unclear. Here, we show that act...
Sp1 links CD46 to CD4 T cell metabolic fitness, survival, and retroviral control [0.03%]
Sp1通过连接CD46来调节CD4+T细胞的代谢、存活和抗逆转录病毒感染功能
Parul Singh,Luopin Wang,Pavitra Ramdas et al.
Parul Singh et al.
CD46, a human-specific complement receptor, regulates gene programs essential for T helper 1 (TH1) cell differentiation, yet how it exerts direct transcriptional control remains unclear. We show that the CD46 signaling domain cytoplasmic ta...
Maziar Divangahi,Eva Kaufmann
Maziar Divangahi
Innate immune memory (trained immunity) is mediated by epigenetic and metabolic reprogramming of innate immune cells and hematopoietic progenitors, enabling altered responses to subsequent challenges. Mechanistically conserved across eukary...
The evolving biology of T cell memory: A dynamic continuum of function and persistence [0.03%]
T细胞记忆的演变生物学：功能和持久性的动态连续体
Stephen J Turner,Daniel Thiele,Nicole L La Gruta
Stephen J Turner
Immunological memory underpins long-term protection and vaccination. Although early work established the durability and recall capacity of memory T cells, understanding of CD8 T cell memory generation, maintenance, and plasticity has advanc...
Memories that endure [0.03%]
难忘的回忆
Leoma Bere,Christiana Fogg,Hannah Isles et al.
Leoma Bere et al.
Multilayered immune memory contributes to lifelong pathogen protection and health.
Sophia Villa,Shiv Pillai
Sophia Villa
IL-4 secreted by ILC2s induces TFH13 cell differentiation and thus drives high-affinity IgE production.