DDX6 induces immunosuppression in cancer by disrupting structural stability of endogenous double-stranded RNAs
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Cellular double-stranded RNA (dsRNA) can activate immune pathways similar to viral RNA. Adenosine deaminases acting on RNA 1 (ADAR1)-mediated adenosine-to-inosine (A-to-I) RNA editing has long been believed to destabilize endogenous dsRNA, thus preventing immu... ...
