Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine [0.03%]
类干细胞组织驻留记忆T细胞控制肠道T细胞记忆的功能异质性和再激活现象
Kevin Man,Vinicius A Duarte da Silva,Nikita Potemkin et al.
Kevin Man et al.
Tissue-resident memory T (TRM) cells provide localized immunity against intracellular pathogens and cancer. Upon antigen reencounter, TRM cells differentiate into effector cells while also giving rise to another generation of memory cells. ...
RNA binding proteins control the G2-M checkpoint of the germinal center B cell [0.03%]
RNA结合蛋白控制生发中心B细胞G2/M检查点
Fiamma Salerno,Alex J Whale,Louise S Matheson et al.
Fiamma Salerno et al.
The germinal center (GC) reaction drives the production of high-affinity antibodies by iterative cycles of B cell somatic hypermutation, selection, and proliferation. How GC B cells undergo rapid cell division while maintaining genome stabi...
Local activation of mutant RIG-I by short noncoding Y-RNA in the kidney triggers lethal nephritis [0.03%]
短非编码Y RNA在肾脏中局部激活突变RIG-I引发致死性肾炎
Saya Satoh,Yaw Bia Tan,Benjamin Heil et al.
Saya Satoh et al.
Detecting viral RNA by the ubiquitously expressed cytosolic receptor retinoic acid-inducible gene I (RIG-I) is critical for antiviral immune responses, including type I interferon (IFN-I) and chemokine induction. RIG-I has evolved to sensit...
Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells [0.03%]
线粒体和溶酶体信号协调调节性T细胞的异质代谢状态
Jordy Saravia,Nicole M Chapman,Yu Sun et al.
Jordy Saravia et al.
Immunotherapies targeting regulatory T (Treg) cells often trigger inflammation and autoimmunity. How Treg cells undergo functional reprogramming to reestablish immune homeostasis under these conditions remains unclear. Here, we demonstrate ...
Lipolysis-microlipophagy cascade regulated by adipose triglyceride lipase drives pathogenic adaptive type 2 immunity [0.03%]
由脂肪甘油三酯脂酶调节的脂解-微脂自噬级联诱导适应性2型免疫反应产生病理效应
Hiroyuki Yagyu,Masahiro Kiuchi,Atsushi Sasaki et al.
Hiroyuki Yagyu et al.
A unique subpopulation of memory T helper 2 (TH2) cells expressing the interleukin-33 (IL-33) receptor ST2 drives allergic disease pathogenesis. However, the immunometabolic mechanisms that induce ST2hi memory TH2 cells remain unclear. We s...
Protein palmitoylation and sphingolipid metabolism control regulated exocytosis in cytotoxic lymphocytes [0.03%]
蛋白质棕榈酰化和鞘脂代谢控制细胞毒淋巴细胞中的受调节性胞外运输现象
Artem Kalinichenko,Jakob Huemer,Theresa Humer et al.
Artem Kalinichenko et al.
Regulated exocytosis controls key cellular functions ranging from neurotransmitter release to the secretion of immune mediators, and its disruption is associated with numerous pathologies. The cytotoxic activity of lymphocytes is particular...
Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates [0.03%]
通过组合生发中心靶向免疫在非人灵长类动物中同时诱导多种广谱中和抗体前体
Henry J Sutton,Krystal M Ma,Jon M Steichen et al.
Henry J Sutton et al.
Inducing broadly neutralizing antibodies (bnAbs) against HIV remains a key challenge in vaccine development. Germline-targeting immunogens have effectively primed bnAb B cell lineages to individual HIV envelope epitopes in humans and nonhum...
Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models [0.03%]
在小鼠模型中，通过靶向祖细胞的mRNA-LNP免疫原同时启动针对HIV广谱中和抗体前体的多种表位的启动效应
Zhenfei Xie,Xuesong Wang,Yu Yan et al.
Zhenfei Xie et al.
Germline-targeting is a promising approach to HIV vaccine development that begins with the elicitation of precursors to broadly neutralizing antibodies (bnAbs), but it remains unclear whether simultaneous elicitation of precursors to multip...
Erratum for the Research Article "METTL1-mediated m7G methylation of Sarm1 mRNA promotes macrophage inflammatory responses and multiple organ injury" by C. Hou et al [0.03%]
C. Hou等发表的研究文章“METTL1介导的Sarm1 mRNA的m7G甲基化促进巨噬细胞炎症反应和多器官损伤”的勘误表
Published Erratum
Science immunology. 2025 Oct 17;10(112):eaec5738. DOI:10.1126/sciimmunol.aec5738 2025
Anticancer immune responses are hindered by cis interaction of inhibitory checkpoint SIRPα [0.03%]
细胞内的抑制性检查点SIRPα通过横向互作阻碍抗癌免疫反应
Zhenghai Tang,Ming-Chao Zhong,Jin Qian et al.
Zhenghai Tang et al.
Signal regulatory protein α (SIRPα) is a macrophage inhibitory receptor that limits phagocytosis and antitumor activity by interacting in trans with CD47 on tumor cells. Here, we found that a component of SIRPα's inhibitory function occu...