Sp1 links CD46 to CD4 T cell metabolic fitness, survival, and retroviral control
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CD46, a human-specific complement receptor, regulates gene programs essential for T helper 1 (TH1) cell differentiation, yet how it exerts direct transcriptional control remains unclear. We show that the CD46 signaling domain cytoplasmic tail 1 (CYT-1) engages... ...
