Keystone Epitope Theory: An Ecological Perspective on RNA Viruses, Tumor Immunoediting, and Vaccine Design [0.03%]
中心表位理论：RNA病毒、肿瘤免疫编辑和疫苗设计的生态学视角
Simon Mallal,Amir Asiaee
Simon Mallal
We propose that persistent, human-adapted DNA organisms shape postnatal immunity by focusing responses on functionally constrained epitopes within tissue niches. Here, we examine rapidly evolving RNA viruses and tumors through that lens. We...
Keystone Epitope Theory: Implications for Hypersensitivity, Autoimmunity, and Transplantation [0.03%]
凯伊斯坦表位理论：对超敏反应、自身免疫和器官移植的启示
Simon Mallal,Amir Asiaee,Elizabeth Phillips
Simon Mallal
HLA class I alleles confer a striking risk for T cell-mediated drug hypersensitivity, yet positive predictive values are low-typically under 10% and as low as 0.12% for some drug-HLA pairs. We propose that persistent, human-adapted pathogen...
Mast Cells Control the Bacterial Burden and Grain Formation in Murine Experimental Actinomycetoma Induced by Nocardia brasiliensis [0.03%]
小鼠实验性放线菌足分枝杆菌瘤中 Mast 细胞控制细菌数量和粒化形成（诱导出 Nocardia brasiliensis）
Tomás Alejandro Suárez-Vázquez,Nallely López-López,Manuel Mejía-Torres et al.
Tomás Alejandro Suárez-Vázquez et al.
Background: The immunopathogenesis of actinomycetoma, a chronic granulomatous infection caused primarily by Nocardia brasiliensis, involves poorly defined mechanisms sustaining its characteristic cyclical inflammation. ...
NF-κB/OCT-1 Mediated Upregulation of CXCL14 Chemokine Mobilizes Mucosal Effector Memory CD44+CD62L-CD4+ and CD8+ TEM Cells, and NK Cells Associated with Protection Against Genital Herpes [0.03%]
NF-κB/OCT-1介导的CXCL14化学因子上调动员黏膜效应记忆细胞(TEM)CD44+CD62L−CD4+和CD8+NK细胞，与生殖器疱疹保护作用相关
Yassir Lekbach,Swayam Prakash,Hawa Vahed et al.
Yassir Lekbach et al.
Background: Mucosal chemokines (eg, CCL25, CCL28, CXCL14, and CXCL17) play key roles in protecting mucosal surfaces against invading infectious pathogens. However, their specific contributions to protection against genita...
A Year in Review on Tuberculosis and Non-tuberculous Mycobacteria Disease: A 2026 Update for Clinicians and Scientists [0.03%]
2026年结核病和非结核分枝杆菌疾病年度进展回顾：临床医师与科研人员必读
Simone Tunesi,Graham Bothamley,Gunar Günther et al.
Simone Tunesi et al.
Background: Tuberculosis (TB) remains a major cause of morbidity and mortality worldwide, while infections from non-tuberculous mycobacteria (NTM) represent a growing public health threat. In its 20th year of activity, th...
Impact of Sex on Viral Shedding and Symptom Severity During Acute COVID-19 [0.03%]
性别对急性COVID-19病毒释放和症状严重程度的影响
Evelyn Kung,Rinki Deo,Manish C Choudhary et al.
Evelyn Kung et al.
Background: To evaluate the impact of sex on acute SARS-CoV-2 infection, 668 participants from the ACTIV-2/A5401 study were followed over a 28-day period. ...
Michael M Lederman,Leonard H Calabrese
Michael M Lederman
In this interview, Eric Topol, MD, reflects on a career defined by a sustained commitment to patient-centered medicine. He describes his early training in cardiology, mentorship grounded in a humanistic approach, and how adaptability has sh...
Distinct Antibody Fc-profiles in Lymph During Homeostasis and Chronic HIV Infection [0.03%]
慢性HIV感染和稳态期间淋巴组织中抗体的Fc特征不同
Ryan P McNamara,Audrey L Butler,Sepideh Dolatshahi et al.
Ryan P McNamara et al.
Background: Antibodies play a critical role in the control of pathogens and tumors through their ability to recognize non-self and then direct immune-mediated destruction. Antibodies are generated by plasma cells or plasm...
Arturo Casadevall Speaks on Curiosity, Resilience, and Scientific Integrity [0.03%]
卡斯达伐谈好奇心、韧性与科研诚信
Robert A Bonomo,Michael M Lederman
Robert A Bonomo
In this interview, Arturo Casadevall, MD, PhD, shares insight into his childhood, what motivated him to go into biomedical research, the impact of the AIDS epidemic, and the lessons learned that he imparts to younger scientists. ...
A Novel Adaptive Platform for Rapid, Simple Flow-Based Antibody Detection Devices Predicts NAb Levels to SARS-CoV-2 [0.03%]
一种新型自适应平台可快速简便地用于基于流式的抗体检测设备，以预测对SARS-CoV-2的中和抗体水平
Alena J Markmann,D Ryan Bhowmik,Baowei Jiang et al.
Alena J Markmann et al.
Background: COVID-19 has caused millions of deaths and continues to burden individuals and the healthcare system. Antibodies that neutralize SARS-CoV-2 have proven to be the most reliable markers of immune protection, tar...