Keystone Epitope Theory: Implications for Hypersensitivity, Autoimmunity, and Transplantation
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HLA class I alleles confer a striking risk for T cell-mediated drug hypersensitivity, yet positive predictive values are low-typically under 10% and as low as 0.12% for some drug-HLA pairs. We propose that persistent, human-adapted pathogens-notably herpesviru... ...
