Eiman Azim,Kazuhiko Seki
Eiman Azim
Coordinated movement depends on constant interaction between neural circuits that produce motor output and those that report sensory consequences. Fundamental to this process are mechanisms for controlling the influence that sensory signals...
Shravani Pasnupneti,Mark R Nicolls
Shravani Pasnupneti
Lung transplantation is a life-saving operation for patients with advanced lung disease. Pulmonary allografts eventually fail because of infection, thromboembolism, malignancy, airway complications, and chronic rejection, otherwise known as...
Christopher W Sundberg,Robert H Fitts
Christopher W Sundberg
Energetic demand from high-intensity exercise can easily exceed ATP synthesis rates of mitochondria leading to a reliance on anaerobic metabolism. The reliance on anaerobic metabolism results in the accumulation of intracellular metabolites...
Luis F Queme,Michael P Jankowski
Luis F Queme
Clinical conditions resulting in musculoskeletal pain show important sex differences in both prevalence and degree of functional disability. The underlying mechanisms for these distinctions in pain manifestation are not fully known. However...
Deirdre Nolfi-Donegan,Tirthadipa Pradhan-Sundd,Kirkwood A Pritchard Jr et al.
Deirdre Nolfi-Donegan et al.
Sickle cell disease (SCD) is characterized by chronic hemolysis and repeated episodes of vascular occlusion leading to progressive organ injury. SCD is characterized by unbalanced, simultaneous pro-oxidant and anti-oxidant processes at the ...
Alice E Kane,David A Sinclair,James R Mitchell et al.
Alice E Kane et al.
Dietary restriction (DR) remains the most reproducible and consistent laboratory intervention to extend lifespan and improve health in mammals. DR has been primarily characterized in males due to issues of cost, perceived heightened variabi...
A tale of ligands big and small: an update on how pentameric ligand-gated ion channels interact with agonists and proteins [0.03%]
大配体与小配体的故事——五聚体配体门控离子通道与激动剂及蛋白质相互作用的最新研究进展
Stephan A Pless,Lucia G Sivilotti
Stephan A Pless
Pentameric ligand-gated ion channels (pLGICs, also known as Cys-loop receptors) are a large family of ion channels expressed in all Bilateria and in several groups of bacteria and archaea. They are activated by small-molecule neurotransmitt...
The rhythm section: An update on spinal interneurons setting the beat for mammalian locomotion [0.03%]
脊髓神经元簇：调控哺乳动物行走步态的关键节律生成中心的更新研究进展
Kimberly J Dougherty,Ngoc T Ha
Kimberly J Dougherty
To initiate and support locomotion, rhythm generating neurons in the spinal central pattern generator convert descending input into a rhythmic signal which is conveyed to downstream neurons, leading to the recruitment of motor neurons and a...
The circadian clock: A tale of genetic-electrical interplay and synaptic integration [0.03%]
昼夜钟：基因-电气相互作用及突触整合的故事
Mino D C Belle,Charles N Allen
Mino D C Belle
Pioneering work in Drosophila uncovered the building blocks of the molecular clock, consisting of transcription-translation feedback loops (TTFLs). Subsequent experimental work demonstrated that the mammalian TTFL is localized in cells and ...
Circadian Control of Neuroendocrine Function: Implications for Health and Disease [0.03%]
昼夜节律对神经内分泌功能的调控及其对健康和疾病的影响
Neta Gotlieb,Jacob Moeller,Lance J Kriegsfeld
Neta Gotlieb
The circadian timing system orchestrates daily rhythms in physiology and behavior via the suprachiasmatic nucleus (SCN), the master brain clock. Because endocrine secretions have far-reaching influence on the brain and periphery, circadian ...