Alina Maloyan
Alina Maloyan
Autophagy is an evolutionarily conserved catabolic process whereby damaged organelles, misfolded proteins, and lipid droplets are sequestered, degraded, and recycled. Definitive etiological links connect dysregulated autophagy to chronic ca...
The Role of Complement and CD4 T Cells in Preeclampsia and Offspring Neurodevelopment [0.03%]
补体和CD4 T细胞在子痫前期及子代神经发育中的作用
Jean F Regal,Courtney A O&#x;Kane,Sabrina M Scroggins
Jean F Regal
Preeclampsia is a multifactorial hypertensive disorder of pregnancy. Dysregulated innate complement activity and skewing of adaptive CD4+ T helper (TH) responses (↑TH1/TH17, ↓Treg) contribute to maternal hypertension, endothelial dysfunct...
Recent insights into the immunobiology of congenital cytomegalovirus infection [0.03%]
先天性巨细胞病毒感染的免疫生物学新见解
Elizabeth Ann L Enninga,Mark R Schleiss,Craig J Bierle
Elizabeth Ann L Enninga
Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection, and therapeutic interventions remain limited. This review highlights recent findings on the immunobiology of HCMV during pregnancy, exploring the roles of mate...
Extracellular Vesicles and the Placenta-Brain Axis: Mechanisms of Shared Risk in Pregnancy and Perinatal Psychiatry [0.03%]
细胞外囊泡和胎盘-大脑轴：妊娠与围产期精神病共病的风险机制
Hannah Hazzard,Brianna Blaine,Benjamin B Borrman et al.
Hannah Hazzard et al.
Disorders of pregnancy and psychiatric conditions in mothers and affected children have high rates of comorbidity and underlying mechanistic overlap. We propose that extracellular vesicles (EVs) may subserve this shared psycho-obstetric ris...
Current diagnostic modalities for detecting myocardial relaxation function in diabetes-associated heart failure or heart failure with preserved ejection fraction [0.03%]
糖尿病相关心力衰竭或射血分数保留型心力衰竭患者诊断心肌舒张功能的方法学进展
Dhrubo Ahmad,Taslima Akter Shila,Yuhui Yang et al.
Dhrubo Ahmad et al.
Impaired cardiac relaxation, or diastolic dysfunction, is a key contributor to heart failure in diabetic patients, making early detection critical for preventing disease progression. This review explores current diagnostic modalities for as...
Sex and Ventricular Remodeling [0.03%]
性与室壁重构
Steven P Jones,Helen E Collins
Steven P Jones
The composite of changes sustained by the left ventricle during pathologic and physiologic stimuli is known as ventricular remodeling. These changes involve alterations to individual cells, the surrounding matrix, and overall ventricular st...
Diego Quiroga,Rachel Daniel,Samarjit Das
Diego Quiroga
MicroRNAs (miRNAs) are essential post-transcriptional regulators of gene expression, and accumulating evidence supports their presence and function within mitochondria. These mitochondrial microRNAs (MitomiRs) modulate key processes such as...
The Link Between Circadian Disruption and Alzheimer's Disease and Related Dementias: Insights from Peripheral Inflammation [0.03%]
昼夜节律紊乱与阿尔茨海默病及相关痴呆症之间的联系：来自外周炎症的见解
Carmalena V Cordi,Jennifer M Hurley
Carmalena V Cordi
Circadian rhythms are essential for maintaining physiological homeostasis, influencing biological processes from the sleep-wake cycle to metabolism and immune responses. Disruption of these rhythms is increasingly linked to the pathogenesis...
Noncoding RNAs in myocardial ischemia/reperfusion injury and repair [0.03%]
非编码RNA在心肌缺血/再灌注损伤与修复中的作用
Mingliang Pan,Zhixin Li,Xiaohong Wang et al.
Mingliang Pan et al.
Myocardial ischemia/reperfusion (I/R) usually triggers a series of molecular and cellular changes, which yield excessive oxidative stress and massive cardiomyocyte death, leading to sterile inflammation, cardiac fibrosis, and, eventually, h...