Novel aspects of the renin-angiotensin-aldosterone system in septic shock [0.03%]
关于败血性休克中肾素血管紧张素醛固酮系统的最新研究进展
Christopher L Schaich,Ashish K Khanna,Mark C Chappell
Christopher L Schaich
Sepsis and septic shock are associated with high mortality rates and constitute the primary cause of death in intensive care units worldwide. Activation of the circulating renin-angiotensin-aldosterone system (RAAS) is an early event, and e...
Circadian rhythms in metabolism and mental health: a reciprocal regulatory network with implications for metabolic and neuropsychiatric disorders [0.03%]
代谢和心理健康中的昼夜节律：与代谢和神经精神障碍相关的相互调节网络
Matthew Lloyd,Brooke A Prakash,Lucy Zhao et al.
Matthew Lloyd et al.
Circadian rhythms orchestrate metabolism and brain function, aligning internal physiological processes with the 24-hour day-night cycle. Growing evidence highlights a reciprocal relationship between circadian regulation, metabolism, and neu...
Mammary gland development and function in maternal obesity and gestational diabetes [0.03%]
肥胖和妊娠糖尿病对乳腺发育及功能的影响
Brian Akhaphong,Emilyn U Alejandro,Kathryn L Schwertfeger
Brian Akhaphong
The mammary gland undergoes dynamic structural and functional remodeling during pregnancy to prepare for lactogenesis, driven by cellular signaling, immune interactions, and microenvironmental cues, including those from adipocytes. In mater...
Myeloid cell renin-angiotensin-aldosterone system in hypertension and inflammation [0.03%]
高血压和炎症中的髓系细胞肾素血管紧张素醛固酮系统
Claude F Albritton,Sepiso K Masenga,Andrea Marshall et al.
Claude F Albritton et al.
This review explores the intersection of the renin-angiotensin-aldosterone system (RAAS) and myeloid cell biology, with particular focus on how their interaction contributes to hypertension pathogenesis and related inflammatory comorbiditie...
Circadian physiology changes with aging: age is just a number, but circadian physiology keeps time [0.03%]
昼夜生理学随衰老而变化：年龄只是一个数字，但昼夜生理学记录时间
Natalie J Bohmke,Karyn A Esser
Natalie J Bohmke
Circadian rhythms are inherent cycles of physiology and behavior that occur over approximately 24 h and are modulated by the cell-autonomous molecular clock. The molecular clocks throughout the body are aligned by the suprachiasmatic nucleu...
Targeting metabolism to protect fertility and healthy pregnancy with SGLT2 inhibitors and GLP-1RAs [0.03%]
靶向代谢保护生育和健康妊娠——SGLT2抑制剂和GLP-1受体激动剂的新机遇
Shannon M Flanary,Kyoko Yoshida,Emilyn U Alejandro et al.
Shannon M Flanary et al.
Metabolic disease is a global health epidemic with detrimental effects on reproduction. The rising use of sodium glucose co-transporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1RAs) have introduced new treatm...
Role of extracellular vesicle-mediated neurodegeneration in substance use disorders [0.03%]
外泌体介导的神经退行性病变在物质使用障碍中的作用
Mohit Kumar,Arnab Saha,Agasou Alfonso Rameau et al.
Mohit Kumar et al.
Substance use disorders (SUDs) remain a complicated and widespread public health problem, characterized by obsessive drug and alcohol use, despite adverse consequences. Emerging research suggests that the extracellular vesicles (EVs) play a...
Impact of microRNAs and long noncoding RNAs in skeletal and cardiac muscles [0.03%]
微小RNA和长非编码RNA在骨骼肌和心肌中的作用
Gabriela P Diniz,Joanne Chan,John D Mably et al.
Gabriela P Diniz et al.
Recent advances in technology have accelerated our ability to define the functions of noncoding RNA (ncRNA). Beyond their known roles in regulating molecular and cellular processes, new mechanisms and interacting partners for ncRNAs have be...
Placental Secretome: Uncovering the Vast Signals Shaping Fetal Metabolic Health Trajectory [0.03%]
胎盘分泌组：揭开塑造胎儿代谢健康轨迹的广泛信号
Seokwon Jo,Emilyn U Alejandro,Megan Beetch
Seokwon Jo
Predisposition to metabolic disease may start during pregnancy, when the intrauterine environment profoundly influences fetal development. The placenta secretes an array of proteins, hormones, metabolites, and extracellular vesicles that co...
Caveolin in extracellular vesicles: orchestrating interorgan communication in diabetes-associated cardiovascular disease☆ [0.03%]
糖尿病相关心血管疾病中的细胞外囊泡小窝蛋白：器官间通讯的调节者
Zhijun Meng,Mary K Sewell-Loftin,Vinoy Thomas et al.
Zhijun Meng et al.
Small extracellular vesicles (sEVs) have been recognized as critical mediators of intercellular communication, impacting processes such as inflammation, tissue repair, and cardiovascular disease progression. Conventionally, research has foc...