TRPC4 as a coincident detector of Gi/o and Gq/11 signaling: mechanisms and pathophysiological implications [0.03%]
作为Gi/o和Gq/11信号巧合检测器的TRPC4：机制及其病理生理意义
Jaepyo Jeon,Jin-Bin Tian,Michael X Zhu
Jaepyo Jeon
TRPC channels are Ca2+-permeable nonselective cation channels activated downstream from phospholipase C (PLC). Although most TRPC channels can be activated by stimulating Gq/11-coupled receptors, TRPC4 requires simultaneous stimulation of G...
Two-pore channels as master regulators of membrane trafficking and endocytic well-being [0.03%]
双孔通道作为膜转运和胞内吞稳态的主要调节器
Kristin Vassileva,Mark Marsh,Sandip Patel
Kristin Vassileva
Two-pore channels (TPCs) are a ubiquitous class of Ca2+- and Na+-permeable ion channels expressed within the endo-lysosomal system. They have emerged as central regulators of a wide array of physiological processes intimately linked to info...
Computational and neurophysiological principles underlying auditory perceptual decisions [0.03%]
听觉感知决策背后的计算和神经生理学原理
Taku Banno,Jean-Hugues Lestang,Yale E Cohen
Taku Banno
A fundamental scientific goal in auditory neuroscience is identifying what mechanisms allow the brain to transform an unlabeled mixture of auditory stimuli into distinct perceptual representations. This transformation is accomplished by a c...
Precision remodeling: how exercise improves mitochondrial quality in myofibers [0.03%]
精准重构：运动如何改善肌纤维中的线粒体质量
Joshua C Drake,Zhen Yan
Joshua C Drake
The profound energetic demand of prolonged exercise imposed upon skeletal muscle and the heart is met by oxidation of substrate within mitochondria. As such, several coordinated events are initiated in order to maintain mitochondria, collec...
Redox Regulation of Metabolic Syndrome: Recent Developments in Skeletal Muscle Insulin Resistance and Non-alcoholic Fatty Liver Disease (NAFLD) [0.03%]
代谢综合征的氧化还原调节：骨骼肌胰岛素抵抗和非酒精性脂肪肝疾病（NAFLD）的新进展
Yee-Hui Yeo,Yen-Chun Lai
Yee-Hui Yeo
Several new discoveries over the past decade have shown that metabolic syndrome, a cluster of metabolic disorders, including increased visceral obesity, hyperglycemia, hypertension, dyslipidemia and low HDL-cholesterol, is commonly associat...
Joshua C Weavil,Markus Amann
Joshua C Weavil
This short review offers a general summary of the consequences of whole body exercise on neuromuscular fatigue pertaining to the locomotor musculature. Research from the past two decades have shown that whole body exercise causes considerab...
Bradford G Hill
Bradford G Hill
Physiologic and pathologic stressors promote changes in metabolism that are associated with cardiac remodeling. Metabolic alterations in the heart are a summation of responses of several organs and organ systems, which transform the milieu ...
Actin cytoskeleton dynamics during mucosal inflammation: a view from broken epithelial barriers [0.03%]
黏膜炎症过程中肌动蛋白细胞骨架的动态变化：来自受损上皮屏障的角度
Susana Lechuga,Andrei I Ivanov
Susana Lechuga
Disruption of epithelial barriers is a key pathogenic event of mucosal inflammation: It ignites the exaggerated immune response and accelerates tissue damage. Loss of barrier function is attributed to the abnormal structure and permeability...
Kanmin Xue,Robert E MacLaren
Kanmin Xue
Retinal degenerations account for the majority of untreatable causes of blindness. Advances in gene delivery vectors, CRISPR/Cas9-based gene editing systems, and electronic engineering have led to a wide range of strategies for correcting v...
Linking the nature and functions of sleep: insights from multimodal imaging of the sleeping brain [0.03%]
探究睡眠的发生机制及其功能：来自多模式脑影像研究的启示
Chen Song,Enzo Tagliazucchi
Chen Song
Sleep and wakefulness are traditionally considered as two mutually exclusive states with contrasting behavioural manifestations and complementary neurobiological functions. However, the discoveries of local sleep in global wakefulness and l...