TRPC4 as a coincident detector of Gi/o and Gq/11 signaling: mechanisms and pathophysiological implications
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TRPC channels are Ca2+-permeable nonselective cation channels activated downstream from phospholipase C (PLC). Although most TRPC channels can be activated by stimulating Gq/11-coupled receptors, TRPC4 requires simultaneous stimulation of Gi/o-coupled receptor... ...
