Rationale and Design of STAMINA: Senolytics To Alleviate Mobility Issues and Neurological Impairments in Aging, A Geroscience Feasibility Study [0.03%]
STAMINA研究的设计与目的：一项关于使用抗衰老因子缓解老年人行动和神经功能损伤的可行性研究
Courtney L Millar,Ike Iloputaife,Kathryn Baldyga et al.
Courtney L Millar et al.
The process of cellular senescence is hypothesized to play a critical role in the development of age-related mobility and cognitive impairments, both of which precede the development of Alzheimer's disease. Therefore, senolytic compounds th...
Multi-ancestry GWAS reveals loci linked to human variation in LINE-1- and Alu-insertion numbers [0.03%]
多祖先全基因组关联研究揭示了与人类LINE-1和Alu插入数变异相关的位点
Juan I Bravo,Lucia Zhang,Bérénice A Benayoun
Juan I Bravo
LINE-1 (L1) and Alu are two families of transposable elements (TEs) occupying ~17% and ~11% of the human genome, respectively. Though only a small fraction of L1 copies is able to produce the machinery to mobilize autonomously, Alu and dege...
Body composition, fear of falling and balance performance in community-dwelling older adults [0.03%]
社区老年人身体组成、恐跌和平衡能力的关系研究
Ladda Thiamwong,Rui Xie,Norma E Conner et al.
Ladda Thiamwong et al.
Objectives: We aimed to 1) assess body composition using a portable technology, bioelectrical impedance analysis, (BIA) and 2) examine the associations between body composition and the discrepancy of fear of falling (FOF)...
Age-related Changes of GAD1 mRNA Expression in the Central Inferior Colliculus [0.03%]
中央下丘GAD1 mRNA的年龄相关性变化
Christina C Koehler,Laila S Almassri,Nick Tokar et al.
Christina C Koehler et al.
Encoding sounds with a high degree of temporal precision is an essential task for the inferior colliculus (IC) to perform and maintain the accurate processing of sounds and speech. However, the age-related reduction of GABAergic neurotransm...
Psychological Stress and Epigenetic Aging in Older Men: The VA Normative Aging Study [0.03%]
老年男性心理压力与表观遗传学衰老：VA规范老龄化研究结果
Jamaji C Nwanaji-Enwerem,Andres Cardenas,Xu Gao et al.
Jamaji C Nwanaji-Enwerem et al.
Psychological stress remains an important risk factor for morbidity and mortality throughout the life course. However, there have been counterintuitive findings reported in previous studies of older persons that examine the relationships of...
Treatment mechanism of immune triad from the repurposing drug against COVID-19 [0.03%]
老药新用的潜在抗新冠病毒药物作用机制——免疫调控三分法模型假说
Jong Hoon Lee
Jong Hoon Lee
COVID-19 is an immune-mediated disease whose pathophysiology uses SAMHD1 tetramerization and cGAS-STING signaling, toll-like receptor 4 (TLR4) cascade, spike protein- inflammasome activation, and neuropilin 1 (NRP1) signaling. Variants of c...
Lack of accelerated ovarian aging in a follicle-stimulating hormone receptor haploinsufficiency model [0.03%]
卵泡刺激素受体半倍合子不足模型中未出现卵巢早衰现象
Kristen Mehalko,Minhoo Kim,Sanjana Paye et al.
Kristen Mehalko et al.
Follicle-stimulation hormone (FSH) and FSH receptor (FSHR) signaling is essential for lifelong ovarian and endocrine functions in females. Previous studies have reported that Fshr haploinsufficiency in female mice led to accelerated ovarian...
Heart failure risk remote monitoring program in the very elderly patients with COVID-19 disease [0.03%]
COVID-19疾病中老年人心力衰竭风险远程监测程序
Abrar-Ahmad Zulfiqar,Emmanuel Andres,Mohamed Hajjam et al.
Abrar-Ahmad Zulfiqar et al.
Caenorhabditis elegans as a model system for studying aging-associated neurodegenerative diseases [0.03%]
秀丽隐杆线虫：研究衰老相关神经退行性疾病的模型系统
Kate M Van Pelt,Matthias C Truttmann
Kate M Van Pelt
Neurodegenerative diseases (NDs) are a heterogeneous group of aging-associated disorders characterized by the disruption of cellular proteostasis machinery and the misfolding of distinct protein species to form toxic aggregates in neurons. ...
Reji Babygirija,Dudley W Lamming
Reji Babygirija
As a key macronutrient and source of essential macromolecules, dietary protein plays a significant role in health. For many years, protein-rich diets have been recommended as healthy due to the satiety-inducing and muscle-building effects o...