Donald Iain MacDonald,John N Wood,Edward C Emery
Donald Iain MacDonald
The sensation of cooling is essential for survival. Extreme cold is a noxious stimulus that drives protective behaviour and that we thus perceive as pain. However, chronic pain patients suffering from cold allodynia paradoxically experience...
Zoë Dworsky-Fried,Bradley J Kerr,Anna M W Taylor
Zoë Dworsky-Fried
Globally, it is estimated that one in five people suffer from chronic pain, with prevalence increasing with age. The pathophysiology of chronic pain encompasses complex sensory, immune, and inflammatory interactions within both the central ...
The NMDAR modulator NYX-2925 alleviates neuropathic pain via a Src-dependent mechanism in the mPFC [0.03%]
一种名为NYX-2925的NMDAR调节剂通过mPFC中的Src依赖性机制缓解神经病理性疼痛
Gladys Morrison,Marina N Asiedu,Jessica M Priebe et al.
Gladys Morrison et al.
Previous studies have shown that oral administration of the NMDAR modulator NYX-2925 alleviates pain in several animal models of neuropathic pain and this appears to be through mPFC, but not spinal, mediated mechanisms. While much is known ...
High trait impulsivity potentiates the effects of chronic pain on impulsive behavior [0.03%]
高冲动性人格特质加剧慢性疼痛对冲动行为的影响
Ana Margarida Cunha,Madalena Esteves,Joana Pereira-Mendes et al.
Ana Margarida Cunha et al.
Preclinical studies on impulsive decision-making in chronic pain conditions are sparse and often contradictory. Outbred rat populations are heterogeneous regarding trait impulsivity manifestations and therefore we hypothesized that chronic ...
EPAC1 and EPAC2 promote nociceptor hyperactivity associated with chronic pain after spinal cord injury [0.03%]
脊髓损伤后与慢性疼痛相关的伤害性感觉神经元高敏化是由EPAC1和EPAC2促进的
Samantha C Berkey,Juan J Herrera,Max A Odem et al.
Samantha C Berkey et al.
Chronic pain following spinal cord injury (SCI) is associated with electrical hyperactivity (spontaneous and evoked) in primary nociceptors. Cyclic adenosine monophosphate (cAMP) signaling is an important contributor to nociceptor excitabil...
Biological and behavioral markers of pain following nerve injury in humans [0.03%]
人类周围神经损伤后的疼痛生物学和行为标志物
S A Holmes,N Barakat,M Bhasin et al.
S A Holmes et al.
The evolution of peripheral and central changes following a peripheral nerve injury imply the onset of afferent signals that affect the brain. Changes to inflammatory processes may contribute to peripheral and central alterations such as al...
Alleviation of paclitaxel-induced mechanical hypersensitivity and hyperalgesic priming with AMPK activators in male and female mice [0.03%]
AMPK激活剂可缓解紫杉醇致小鼠机械性痛敏和痛觉过敏增强效应
Kufreobong E Inyang,Timothy A McDougal,Eric D Ramirez et al.
Kufreobong E Inyang et al.
AMP-activated protein kinase (AMPK) is an energy-sensing kinase that has emerged as a novel therapeutic target for pain due to its ability to inhibit mechanistic target of rapamycin (mTOR) and mitogen activated protein kinase (MAPK) signali...
Monosodium iodoacetate-induced monoarthritis develops differently in knee versus ankle joint in rats [0.03%]
膝关节与踝关节一滴法胶原诱导性关节炎的区别及其机制研究
Kristina Ängeby Möller,Stephanie Klein,Frank Seeliger et al.
Kristina Ängeby Möller et al.
Objective: Disability and movement-related pain are major symptoms of joint disease, motivating the development of methods to quantify motor behaviour in rodent joint pain models. We compared effects on behaviour, assesse...
Voluntary exercise reduces both chemotherapy-induced neuropathic nociception and deficits in hippocampal cellular proliferation in a mouse model of paclitaxel-induced peripheral neuropathy [0.03%]
自愿锻炼可减轻紫杉醇诱导的外周神经病理性疼痛及其海马细胞增殖缺陷
Richard A Slivicki,Sonali S Mali,Andrea G Hohmann
Richard A Slivicki
Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side-effect of all major chemotherapeutic agents. Here, we explored efficacy of voluntary exercise as a nonpharmacological strategy for suppressing two distinct adv...
Neurobiology of Pain [0.03%]
疼痛的神经生物学
Fernando Cervero
Fernando Cervero