Modulation of posterior insula selectively enhances nociceptive sensory gating in healthy humans [0.03%]
健康人类后绝缘皮层的调节选择性增强伤害感受性感觉门控功能
Wynn Legon,Gabriel Isaac,Aditya Kapoor et al.
Wynn Legon et al.
Sensory gating - the brains ability to filter out repetitive sensory input - is essential for preventing sensory overload. Impaired gating is frequently observed in nociplastic and other chronic overlapping pain conditions, yet the specific...
Paclitaxel induced-mechanical hypersensitivity is associated with time-dependant pro-inflammatory galectin-3+ macrophages accumulation in the dorsal root ganglia [0.03%]
紫杉醇诱导的机械性疼痛与背根神经节中时间依赖性的促炎性半乳糖凝集素-3阳性巨噬细胞堆积有关
Lynda Zeboudj,Marzia Malcangio
Lynda Zeboudj
Neuropathic pain is a dose-limiting side effect of chemotherapeutic agents such as paclitaxel, and it is unsuccessfully treated by available analgesics. Among the mechanisms underlying paclitaxel-induced neuropathic pain, neuroimmune intera...
Eukaryotic initiation factor 3d regulates context-dependent pain hypersensitivity through the integrated stress response [0.03%]
泛素蛋白酶体应激激活疼痛敏化的整合应力反应及其治疗意义
Subhaan M Mian,Sera I Nakisli,Brodie J Woodall et al.
Subhaan M Mian et al.
Eukaryotic translation initiation factor 3 subunit D (eIF3d) is a noncanonical cap binding protein implicated in selective mRNA translation under stress conditions. Here, we investigate the contribution of eIF3d to pain processing using a h...
Sex differences in nerve injury-induced neuropathic pain via REST in primary sensory neurons [0.03%]
REST在初级感觉神经元中的作用介导性别差异性外周神经损伤引起的神经病理性疼痛反应
Aadhya Tiwari,Ashok Subedi,Asieh Etemad et al.
Aadhya Tiwari et al.
REST is a transcriptional repressor that regulates neuronal gene expression and neural cell identity. Recent studies have examined whether sex influences neuropathic pain (NP), yet findings remain inconsistent. Spared Nerve Injury (SNI) ind...
Wavelength dependence of acute, light-evoked recruitment of brainstem pain-modulating systems in female rats [0.03%]
雌性大鼠急性光诱发招募脑干疼痛调节系统的波长依赖性
Zhigang Shi,Stephanie Radu,Melissa Martenson et al.
Zhigang Shi et al.
Chronic pain states are often associated with sensory hypersensitivities, including acute sensitivity to light. White light exposure has been shown to activate a significant subset of pain-facilitating neurons and suppress firing of pain-in...
Transcriptomic analysis and high throughput functional characterization of human induced pluripotent stem cell derived sensory neurons [0.03%]
人诱导多能干细胞来源的感觉神经元的转录组分析及高通量功能表征
Vincent Truong,Jackson Brougher,Tim Strassmaier et al.
Vincent Truong et al.
Peripheral sensory neurons are a primary effector in pain neurotransmission, and have become a useful cellular model for the study of pain. While rodent tissue has historically served as a source of these neurons, it has become increasingly...
Relationship between brain metabolites and chronic pain mechanisms in knee osteoarthritis pre- and post-total knee replacement [0.03%]
全膝置换术前术后膝骨关节炎患者脑代谢产物与慢性疼痛机制的相关性研究
Samantha A Leech,Marilena M DeMayo,Tiffany K Bell et al.
Samantha A Leech et al.
Impaired descending modulation and heightened pain sensitivity are thought to contribute to pain in knee osteoarthritis (KOA) and its persistence after total knee arthroplasty (TKA). These mechanisms can be assessed using quantitative senso...
Biophysical dissection of nociceptor hyperexcitability caused by a Nav1.8 gain-of-function mutation linked to severe pain [0.03%]
Nav1.8_gain-of-function突变引起的痛觉异常增敏的机理研究
Dmytro V Vasylyev,Peng Zhao,Stephen G Waxman
Dmytro V Vasylyev
Voltage-gated sodium channel Nav1.8 is highly expressed in nociceptors, where it plays a critical role in sustaining repetitive action potential (AP) firing. Gain-of-function Nav1.8 mutations that increase nociceptor excitability have been ...
Pain-Induced changes in corticospinal excitability are associated with adaptive changes in muscle coordination [0.03%]
疼痛引起的皮质脊髓兴奋性变化与肌肉协调的适应性变化有关
Arnaud Duport,Gaspard Diotalevi,Pierre Morel et al.
Arnaud Duport et al.
Most pain studies overlook the relationship between corticomotor function changes and coordinated muscle patterns in voluntary movement. A pre-post study was performed to investigate relationships between changes in corticospinal excitabili...
White matter differences in motor and affective-motivational networks of pain-indifferent carriers of the R221W mutation [0.03%]
R221W突变痛感觉无动于衷携带者中疼痛相关运动网络和情感-动机网络的白质差异
Arnas Tamasauskas,Irene Perini,Jan Minde et al.
Arnas Tamasauskas et al.
The R221W mutation on the nerve growth factor gene results in reduced peripheral C-nociceptor density and behavioural indifference to painful stimuli. While functional neuroimaging has revealed altered cortical and sub-cortical pain process...