Xpro®1595 alleviates neuropathic pain by targeting spinal dorsal horn ADAM17-mediated inflammation [0.03%]
Xpro®1595通过靶向脊髓背角ADAM17介导的炎症缓解神经病理性疼痛
Li Li,Yidie Su,Ling-Ling Sun et al.
Li Li et al.
A disintegrin and metalloprotease 17 (ADAM17) mediates the shedding of key pro-inflammatory cytokines, yet its specific contribution to neuropathic pain remains elusive. Here, we investigated the role of ADAM17 in the rat spinal nerve ligat...
Context dependent roles of FGF13B-NaV1.7 interaction in pain signaling [0.03%]
FGF13B与NaV1.7在痛觉信号传导中的作用机制研究
Erick J Rodríguez-Palma,Samantha Perez-Miller,Kimberly Gomez et al.
Erick J Rodríguez-Palma et al.
Voltage-gated sodium channels, such as NaV1.7, serve as pivotal regulators of sensory neuron excitability and nociception. While gain- and loss-of-function mutations in SCN9A cause inherited pain syndromes or congenital insensitivity to pai...
Females show enhanced susceptibility to develop nerve injury and constant joint pain compared to males in a mouse model of knee joint pain [0.03%]
在膝关节痛小鼠模型中，雌性比雄性更容易产生神经损伤和持续性关节痛
Madison G Mueth,Abigail Del Greco,Tyler Vesey et al.
Madison G Mueth et al.
Arthritis is a leading cause of diminished quality of life from chronic pain and disability and is more severe in female patients. Arthritis pain is difficult to manage due to its heterogeneous nature. Patients report joint pain during use ...
Peripheral immune response and axonal degeneration in the hind paw skin of mice with experimental autoimmune encephalomyelitis [0.03%]
实验性自身免疫性脑脊髓炎小鼠后肢皮肤的外周免疫反应和轴突变性
Andrea G Klassen,Timothy N Friedman,Gustavo Tenorio et al.
Andrea G Klassen et al.
Multiple sclerosis (MS) is traditionally considered a central nervous system (CNS) disease characterized by chronic inflammation and demyelination in the brain and spinal cord, often resulting in debilitating neuropathic pain. While the pri...
Differential Cortico-Thalamic reorganization in Opioid-Induced hyperalgesia and neuropathic pain male rats [0.03%]
阿片类致痛和神经病理性疼痛雄性大鼠皮层丘脑重塑的差异性研究
Aoling Cai,Qing Liu,Wenchang Zhou et al.
Aoling Cai et al.
Both opioid use and peripheral nerve injury can lead to hyperalgesia. Whereas in peripheral nerve injury, the central neuroplastic is secondary to sustained peripheral signaling, opioid-induced hyperalgesia (OIH) involves maladaptive altera...
Lauren Nguyen,Mikhail Umorin,Phillip R Kramer
Lauren Nguyen
Neurexin 3 (Nrxn3) has a role in neuronal signaling. Previous reports indicated that reducing Nrxn3 expression in the central amygdala increased orofacial neuropathic pain. A common temporomandibular disorder is myofascial pain. Thus, we hy...
FL/FLT3 signaling enhances mechanical pain hypersensitivity through Interleukin-1 beta (IL-1β) in male mice [0.03%]
FLT3信号通过白细胞介素-1β(IL-1β)增强小鼠机械性疼痛过敏症状
Corinne Sonrier,Chamroen Sar,Ivo Melo et al.
Corinne Sonrier et al.
Fms-like tyrosine kinase 3 (FLT3) plays a critical role in chronic pain through its ligand FL, a cytokine that triggers mechanical pain hypersensitivity. However, the underlying molecular mechanisms remain unclear. Here, we investigate the ...
Editorial commitment to trust and integrity in science: Implications for pain and anesthesiology research [0.03%]
论疼痛和麻醉学研究中的信任与诚信问题给编辑工作带来的挑战及应对策略——兼评《关于科学出版的自愿性指导原则》之利弊优缺点
Tonya M Palermo,Didier Bouhassira,Karen D Davis et al.
Tonya M Palermo et al.
Glutamate levels in the cingulate cortex are associated with objective markers of pain sensitivity by way of pre-stimulus alpha band oscillations [0.03%]
舌回谷氨酸与通过alpha频段振荡的痛觉敏感性的客观指标有关
Paulina S Scheuren,Oscar Ortiz,Lukas D Linde et al.
Paulina S Scheuren et al.
Pain varies substantially from one individual to the next. Understanding the role of brain function in variations to pain, both in health and disease, represents an important steppingstone towards individualized pain management. This study ...
Left nucleus accumbens volume is associated with poor sleep in hip osteoarthritis [0.03%]
骨关节炎患者的左侧伏隔核体积与睡眠质量差有关
Natalia Egorova-Brumley,Luiza Bonfim Pacheco,Gabby Knox et al.
Natalia Egorova-Brumley et al.
Objective: Reduction in the volume of the nucleus accumbens (NAc) has emerged as a promising signature of chronic pain transition, including in osteoarthritis (OA). Yet, less is known about the factors that could influenc...