Transcriptomic analysis and high throughput functional characterization of human induced pluripotent stem cell derived sensory neurons [0.03%]
Vincent Truong,Jackson Brougher,Tim Strassmaier et al.
Vincent Truong et al.
Peripheral sensory neurons are a primary effector in pain neurotransmission, and have become a useful cellular model for the study of pain. While rodent tissue has historically served as a source of these neurons, it has become increasingly...
Relationship between brain metabolites and chronic pain mechanisms in knee osteoarthritis pre- and post-total knee replacement [0.03%]
Samantha A Leech,Marilena M DeMayo,Tiffany K Bell et al.
Samantha A Leech et al.
Impaired descending modulation and heightened pain sensitivity are thought to contribute to pain in knee osteoarthritis (KOA) and its persistence after total knee arthroplasty (TKA). These mechanisms can be assessed using quantitative senso...
Biophysical dissection of nociceptor hyperexcitability caused by a Nav1.8 gain-of-function mutation linked to severe pain [0.03%]
Nav1.8_gain-of-function突变引起的痛觉异常增敏的机理研究
Dmytro V Vasylyev,Peng Zhao,Stephen G Waxman
Dmytro V Vasylyev
Voltage-gated sodium channel Nav1.8 is highly expressed in nociceptors, where it plays a critical role in sustaining repetitive action potential (AP) firing. Gain-of-function Nav1.8 mutations that increase nociceptor excitability have been ...
Pain-Induced changes in corticospinal excitability are associated with adaptive changes in muscle coordination [0.03%]
疼痛引起的皮质脊髓兴奋性变化与肌肉协调的适应性变化有关
Arnaud Duport,Gaspard Diotalevi,Pierre Morel et al.
Arnaud Duport et al.
Most pain studies overlook the relationship between corticomotor function changes and coordinated muscle patterns in voluntary movement. A pre-post study was performed to investigate relationships between changes in corticospinal excitabili...
White matter differences in motor and affective-motivational networks of pain-indifferent carriers of the R221W mutation [0.03%]
R221W突变痛感觉无动于衷携带者中疼痛相关运动网络和情感-动机网络的白质差异
Arnas Tamasauskas,Irene Perini,Jan Minde et al.
Arnas Tamasauskas et al.
The R221W mutation on the nerve growth factor gene results in reduced peripheral C-nociceptor density and behavioural indifference to painful stimuli. While functional neuroimaging has revealed altered cortical and sub-cortical pain process...
Xpro®1595 alleviates neuropathic pain by targeting spinal dorsal horn ADAM17-mediated inflammation [0.03%]
Xpro®1595通过靶向脊髓背角ADAM17介导的炎症缓解神经病理性疼痛
Li Li,Yidie Su,Ling-Ling Sun et al.
Li Li et al.
A disintegrin and metalloprotease 17 (ADAM17) mediates the shedding of key pro-inflammatory cytokines, yet its specific contribution to neuropathic pain remains elusive. Here, we investigated the role of ADAM17 in the rat spinal nerve ligat...
Context dependent roles of FGF13B-NaV1.7 interaction in pain signaling [0.03%]
FGF13B与NaV1.7在痛觉信号传导中的作用机制研究
Erick J Rodríguez-Palma,Samantha Perez-Miller,Kimberly Gomez et al.
Erick J Rodríguez-Palma et al.
Voltage-gated sodium channels, such as NaV1.7, serve as pivotal regulators of sensory neuron excitability and nociception. While gain- and loss-of-function mutations in SCN9A cause inherited pain syndromes or congenital insensitivity to pai...
Females show enhanced susceptibility to develop nerve injury and constant joint pain compared to males in a mouse model of knee joint pain [0.03%]
在膝关节痛小鼠模型中，雌性比雄性更容易产生神经损伤和持续性关节痛
Madison G Mueth,Abigail Del Greco,Tyler Vesey et al.
Madison G Mueth et al.
Arthritis is a leading cause of diminished quality of life from chronic pain and disability and is more severe in female patients. Arthritis pain is difficult to manage due to its heterogeneous nature. Patients report joint pain during use ...
Peripheral immune response and axonal degeneration in the hind paw skin of mice with experimental autoimmune encephalomyelitis [0.03%]
实验性自身免疫性脑脊髓炎小鼠后肢皮肤的外周免疫反应和轴突变性
Andrea G Klassen,Timothy N Friedman,Gustavo Tenorio et al.
Andrea G Klassen et al.
Multiple sclerosis (MS) is traditionally considered a central nervous system (CNS) disease characterized by chronic inflammation and demyelination in the brain and spinal cord, often resulting in debilitating neuropathic pain. While the pri...
Differential Cortico-Thalamic reorganization in Opioid-Induced hyperalgesia and neuropathic pain male rats [0.03%]
阿片类致痛和神经病理性疼痛雄性大鼠皮层丘脑重塑的差异性研究
Aoling Cai,Qing Liu,Wenchang Zhou et al.
Aoling Cai et al.
Both opioid use and peripheral nerve injury can lead to hyperalgesia. Whereas in peripheral nerve injury, the central neuroplastic is secondary to sustained peripheral signaling, opioid-induced hyperalgesia (OIH) involves maladaptive altera...