SARS-CoV-2 mutations altering regulatory properties: Deciphering host's and virus's perspectives [0.03%]
改变调控性质的SARS-CoV-2突变：从宿主和病毒的角度解读
Abul Bashar Mir Md Khademul Islam,Md Abdullah-Al-Kamran Khan
Abul Bashar Mir Md Khademul Islam
Since the first recorded case of the SARS-CoV-2, it has acquired several mutations in its genome while spreading throughout the globe. In this study, we investigated the significance of these mutations by analyzing the host miRNA binding an...
Serotonin transporter untranslated regions influence mRNA abundance and protein expression [0.03%]
血清素转运蛋白非翻译区影响mRNA量和蛋白质表达
Christopher Manzella,Megha Singhal,Max Ackerman et al.
Christopher Manzella et al.
The serotonin transporter (SERT, SLC6A4) is a Na+-dependent transporter that regulates the availability of serotonin (5-HT, 5-hydroxytryptamine), a key neurotransmitter and hormone in the brain and the intestine. The human SERT gene consist...
Diversity and genomic determinants of the microbiomes associated with COVID-19 and non-COVID respiratory diseases [0.03%]
与COVID-19和非COVID呼吸系统疾病相关的微生物组的多样性和基因组决定因素
M Nazmul Hoque,M Shaminur Rahman,Rasel Ahmed et al.
M Nazmul Hoque et al.
The novel coronavirus disease 2019 (COVID-19) is a rapidly emerging and highly transmissible disease caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Understanding the microbiomes associated with the upper respira...
Analysis of single nucleotide polymorphisms between 2019-nCoV genomes and its impact on codon usage [0.03%]
2019-nCoV基因组单核苷酸多态性分析及其对密码子使用的影响
Suruchi Gupta,Prosenjit Paul,Ravail Singh
Suruchi Gupta
The spread of SARS-CoV-2 is a global concern that has taken a toll on entire human health. Researchers across the globe have been working in devising the strategies to combat this dreadful disease. Studies focused on genetic variability hel...
Gene expression analysis of MCF7 cell lines of breast cancer treated with herbal extract of Cissampelos pareira revealed association with viral diseases [0.03%]
基因表达分析揭示了卡氏独活(Cissampelos pareira)植物提取物治疗的乳腺癌MCF7细胞系与病毒性疾病之间的关联
Emine Güven
Emine Güven
Background: It is necessary to assess the cellular, molecular, and pathogenetic characteristics of COVID-19 and attention is required to understand highly effective gene targets and mechanisms. In this study, we suggest u...
Whole genome comparison of Pakistani Corona virus with Chinese and US Strains along with its predictive severity of COVID-19 [0.03%]
巴基斯坦冠状病毒与中国及美国流感株的全基因组比较及其对COVID-19严重性的预测
Rashid Saif,Tania Mahmood,Aniqa Ejaz et al.
Rashid Saif et al.
Initially submitted 784 SARS-nCoV2 whole genome sequences on NCBI Virus database were selected for phylogenetic analysis to look into their similarities with two of Pakistani sequenced coronavirus strains having accessions of MT240479 and M...
Application of newly developed SARS-CoV2 serology test along with real-time PCR for early detection in health care workers and on-time plasma donation [0.03%]
用于早期发现医护人员及适时捐献血浆的新型冠状病毒血清学检测方法与实时荧光定量PCR的应用研究
Mohammad Sadegh Soltani-Zangbar,Leili Aghebati-Maleki,Mahsa Hajivalili et al.
Mohammad Sadegh Soltani-Zangbar et al.
Background: As the daily number of coronavirus infection disease 19 (COVID19) patients increases, the necessity of early diagnosis becomes more obvious. In this respect, we aimed to develop a serological test for specific...
An overview of basic molecular biology of SARS-CoV-2 and current COVID-19 prevention strategies [0.03%]
SARS-CoV-2的基本分子生物学和当前的COVID-19预防策略综述
Ankur Das,Raja Ahmed,Suraiya Akhtar et al.
Ankur Das et al.
Coronavirus Disease 2019 (COVID-19) manifests as extreme acute respiratory conditions caused by a novel beta coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which is reported to be the seventh coronavirus to i...
Comparative analysis of mutational hotspots in the spike protein of SARS-CoV-2 isolates from different geographic origins [0.03%]
不同地理来源的SARS-CoV-2分离株刺突蛋白突变热点的比较分析
Sanghoo Lee,Mi-Kyeong Lee,Hyeongkyun Na et al.
Sanghoo Lee et al.
The spike (S) protein mutations of SARS-CoV-2 are of major concern in terms of viral transmission and pathogenesis. Hence, we developed a PCR-based method to rapidly detect the 6 mutational hotspots (H49Y, G476S, V483A, H519Q, A520S, and D6...
Gunnar Gottschalk,Konstance Knox,Avik Roy
Gunnar Gottschalk
Upregulation of Angiotensin Converting Enzyme-2 (ACE2) was frequently observed in patients with lung cancer. Interestingly, our recent study revealed that the same ACE2 receptor was also strongly upregulated in lungs during SARS-CoV2 infect...