Arylamine N-Acetyltransferase 1 Knockout in Immortalized Human Bronchial Cells Results in a Reduction of Cellular Growth [0.03%]
人支气管上皮细胞中N-乙酰转移酶1基因敲除导致细胞生长减缓
Sandra S Diven,Kate Tarvestad-Laise,David W Hein et al.
Sandra S Diven et al.
Arylamine N-acetyltransferase 1 (NAT1) is a xenobiotic metabolizing enzyme. NAT1 has recently been proposed to have a non-canonical role in cancer cells, where NAT1 knockout (KO) results in reduced cell growth, cancer properties, and altere...
Sox9 regulates Papss2 mRNA expression through derepression of the transcriptional repressor, C/EBPβ, in chondrogenic cells [0.03%]
SOX9通过去抑制转录抑制因子C/EBPβ在软骨细胞中调节PAPSS2 mRNA的表达
Cunren Liu,Rosa Serra
Cunren Liu
Objectives: Previously, we showed that Papss2 expression is regulated by Sox9 in primary chondrocytes and a chondrogenic cell line, ATDC5. Here we explore molecular mechanisms whereby Sox9 regulates mouse Papss2 mRNA expr...
Genomic insight into the high-risk hypervirulent multidrug resistant enteroaggregative-hemorrhagic Escherichia coli ST648/*a194 (serotype O8:H4) isolated from a 3-year-old patient with bloodstream infection in Uganda, sub-Saharan Africa [0.03%]
从非洲撒哈拉以南乌干达地区一例败血症患儿体内分离的高风险毒力、多重耐药聚集性-出血性肠炎致病菌ST648/*a194（O8:H4血清型）的基因组学研究新进展
Reuben S Maghembe,Maximilian A K Magulye,Abdalah Makaranga et al.
Reuben S Maghembe et al.
Gastrointestinal and bloodstream infections account for a major cause of medical emergency and mortality among pediatric populations. Although Escherichia coli is implicated in multiple infections, its virulence and antimicrobial resistance...
STAT3 single-nucleotide variants in autoimmune thyroid disease in the Pakhtun population of Khyber Pakhtunkhwa, Pakistan [0.03%]
巴基斯坦西北部帕克图克人自身免疫性甲状腺疾病中STAT3单核苷酸变异的研究
Khayyam Khan,Muhammad Zahid,Niaz Ali et al.
Khayyam Khan et al.
The current study was conducted to assess the relationship between the STAT3 gene variants rs744166 and rs2293152 and autoimmune thyroid disorder in the Pakhtun population of the province, of Khyber Pakhtunkhwa, Pakistan. Blood was collecte...
Genetic contributions to pain modulation in sickle cell: A focus on single nucleotide polymorphisms [0.03%]
镰状细胞病痛觉调制的遗传因素:重点关注单核苷酸多态性
Katrina R Hamilton,Lakeya S McGill,Claudia M Campbell et al.
Katrina R Hamilton et al.
Background: Despite recent advances in our knowledge of genetic contributions to the highly variable sickle cell disease (SCD) phenotype, our understanding of genetic factors associated with pain sensitivity in SCD remain...
Identification of RNA-based cell-type markers for stem-cell manufacturing systems with a statistical scoring function [0.03%]
用于干细胞制造系统的基于RNA的细胞类型标志物的统计评分函数鉴定方法
Yu Shi,Weilong Yang,Haishuang Lin et al.
Yu Shi et al.
Cell-type biomarkers are useful in stem-cell manufacturing to monitor cell purity, quantity, and quality. However, the study on cell-type markers, specifically for stem cell manufacture, is limited. Emerging questions include which RNA tran...
Evaluation of Tcell exhaustion based on the expression of EOMES, Tbet and co-inhibitory receptors in severe and non-severe covid-19 patients [0.03%]
基于EOMES、Tbet和协同抑制受体的表达评估重度及非重度COVID-19患者T细胞耗竭情况
Amir Mohammad Saeedifar,Khodayar Ghorban,Ali Ganji et al.
Amir Mohammad Saeedifar et al.
During viral infections, especially Covid-19, Tcell exhaustion plays a crucial role in reducing the activity of lymphocytes and the immune system's antiviral activities. This research aimed to investigate the co-inhibitory receptors and tra...
Pankaj Shrivastava,Toshi Jain,Vijay Nema et al.
Pankaj Shrivastava et al.
Wharton's jelly-mesenchymal stem cells treatment for severe COVID 19 patients: 1-year follow-up [0.03%]
沃顿胶间充质干细胞治疗严重COVID 19患者的治疗：一年随访研究
Mahshid Saleh,Amir Abbas Vaezi,Amir Ali Sohrabpour et al.
Mahshid Saleh et al.
Background: Recently, attention has been focused on mesenchymal stem cells (MSC) because of their unique ability to suppress inflammation induced by cytokine storms caused by COVID-19. Several patients have been successfu...
Whole exome sequencing identifies a rare variant in MAS1 gene in a subject with lethal COVID-19 [0.03%]
全外显子测序在一名致命COVID-19患者中发现MAS1基因中的罕见变异
Alessia Azzarà,Ilaria Cassano,Maria Cristina Tirindelli et al.
Alessia Azzarà et al.
COVID-19 may be considered a multifactorial disease caused by the interaction between the virus itself, as the environmental contribute, and the genetic background of the host. SARS-CoV-2 infection occurs through the interaction between the...