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Comparative analysis of mutational hotspots in the spike protein of SARS-CoV-2 isolates from different geographic origins

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The spike (S) protein mutations of SARS-CoV-2 are of major concern in terms of viral transmission and pathogenesis. Hence, we developed a PCR-based method to rapidly detect the 6 mutational hotspots (H49Y, G476S, V483A, H519Q, A520S, and D614G) in the S protei... ...