Günter Mayer,Tjasa Legen,Tejal Patwari et al.
Günter Mayer et al.
In a recent issue of Cell Chemical Biology, Gray et al. (2020) report an aptamer-based method to reversibly label and isolate EGF receptor-expressing cells from heterogeneous mixtures by cell sorting approaches. Subsequent treatment using c...
J Andrew Alspaugh
J Andrew Alspaugh
In this issue of Cell Chemical Biology, Caplan et al. (2020) describe a series of studies in the human fungal pathogen Candida albicans to identify a new target for antimicrobial drug development. Beginning with an unbiased compound screen,...
Ayumu Taguchi,Johannes F Fahrmann,Samir M Hanash
Ayumu Taguchi
Carbamoyl phosphate synthetase 1 (CPS1) drives ammonia conversion to carbamoyl phosphate, and its overexpression supports pyrimidine synthesis and tumor growth, highlighting the potential of CPS1 inhibition as a therapeutic target. In this ...
Daigo Inoyama,Divya Awasthi,Glenn C Capodagli et al.
Daigo Inoyama et al.
Published Mycobacterium tuberculosis β-ketoacyl-ACP synthase KasA inhibitors lack sufficient potency and/or pharmacokinetic properties. A structure-based approach was used to optimize existing KasA inhibitor DG167. This afforded indazole J...
Pharmacological Complementation Remedies an Inborn Error of Lipid Metabolism [0.03%]
药物互补可治疗一种脂质代谢先天性错误
Meredith D Hartley,Mitra D Shokat,Margaret J DeBell et al.
Meredith D Hartley et al.
X-linked adrenoleukodystrophy (X-ALD) is a rare, genetic disease in which increased very long chain fatty acids (VLCFAs) in the central nervous system (CNS) cause demyelination and axonopathy, leading to neurological deficits. Sobetirome, a...
Jiao Liu,Feimei Kuang,Guido Kroemer et al.
Jiao Liu et al.
Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved cellular process capable of degrading various biological molecules (e.g., protein, glycogen, lipids, DNA, and RNA) and organelles (e.g., mitochondria, endopl...
Targeted In Situ Protein Diversification and Intra-organelle Validation in Mammalian Cells [0.03%]
哺乳动物细胞内的目标蛋白分化及亚细胞器内有效验证
Mutlu Erdogan,Arne Fabritius,Jérome Basquin et al.
Mutlu Erdogan et al.
Engineered proteins must be phenotypically selected for function in the appropriate physiological context. Here, we present a versatile approach that allows generating panels of mammalian cells that express diversified heterologous protein ...
Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors [0.03%]
用于癌症药物研发的共价抑制剂靶向作用于磷脂激酶PI5P4K家族
Sindhu Carmen Sivakumaren,Hyeseok Shim,Tinghu Zhang et al.
Sindhu Carmen Sivakumaren et al.
The PI5P4Ks have been demonstrated to be important for cancer cell proliferation and other diseases. However, the therapeutic potential of targeting these kinases is understudied due to a lack of potent, specific small molecules available. ...
MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome [0.03%]
MYC调节D2HGDH和L2HGDH影响表观基因组和表遗传组
ZhiJun Qiu,An-Ping Lin,Shoulei Jiang et al.
ZhiJun Qiu et al.
Mitochondrial D2HGDH and L2HGDH catalyze the oxidation of D-2-HG and L-2-HG, respectively, into αKG. This contributes to cellular homeostasis in part by modulating the activity of αKG-dependent dioxygenases. Signals that control the expre...
Maria Toro-Moreno,Emily R Derbyshire
Maria Toro-Moreno
In this issue of Cell Chemical Biology, Murithi et al. (2020) integrate stage-specific phenotypic screening and metabolomics to uncover modes of action of antimalarials. This work highlights compounds with potent activity against all asexua...